Motility-limited aggregation of mammary epithelial cells into fractal-like clusters
Leggett SE, Neronha ZJ, Bhaskar D, Sim JY, Perdikari TM, Wong IY. Motility-limited aggregation of mammary epithelial cells into fractal-like clusters. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17298-17306. PMID: 31413194, PMCID: PMC6717304, DOI: 10.1073/pnas.1905958116.Peer-Reviewed Original ResearchBreast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels
Khoo AS, Valentin TM, Leggett SE, Bhaskar D, Bye EM, Benmelech S, Ip BC, Wong IY. Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels. ACS Biomaterials Science & Engineering 2019, 5: 4341-4354. PMID: 31517039, PMCID: PMC6739834, DOI: 10.1021/acsbiomaterials.9b00519.Peer-Reviewed Original ResearchCell-matrix adhesionStrong cell-matrix adhesionMesenchymal morphologyCancer cell transitionCancer cellsCollagen I concentrationAmoeboid morphologyMetastatic breast cancer cellsCancer cell migrationCytoskeletal functionECM protein concentrationMigration phenotypeAmoeboid migrationCell transitionMesenchymal migrationBiochemical cuesBreast cancer cellsCell migrationExtracellular matrixRounded morphologyBiphasic dependencePlate formatCollagen ICellsBiomaterial platform