Polarization and migration in the zebrafish posterior lateral line system
Knutsdottir H, Zmurchok C, Bhaskar D, Palsson E, Nogare D, Chitnis A, Edelstein-Keshet L. Polarization and migration in the zebrafish posterior lateral line system. PLOS Computational Biology 2017, 13: e1005451. PMID: 28369079, PMCID: PMC5393887, DOI: 10.1371/journal.pcbi.1005451.Peer-Reviewed Original ResearchConceptsPosterior lateral line primordiumZebrafish posterior lateral line systemCell-cell adhesionLateral line primordiumCollective cell migrationPosterior lateral line systemCell-based simulationsMutant phenotypeZebrafish embryosCell divisionFGF ligandsLateral line systemCell migrationTrailing cellsSensory structuresObserved motilityChemotaxisCellsImportant roleCXCL12aPrimordiaAdhesionEmbryosMigrationPhenotypeBreast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels
Khoo AS, Valentin TM, Leggett SE, Bhaskar D, Bye EM, Benmelech S, Ip BC, Wong IY. Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels. ACS Biomaterials Science & Engineering 2019, 5: 4341-4354. PMID: 31517039, PMCID: PMC6739834, DOI: 10.1021/acsbiomaterials.9b00519.Peer-Reviewed Original ResearchCell-matrix adhesionStrong cell-matrix adhesionMesenchymal morphologyCancer cell transitionCancer cellsCollagen I concentrationAmoeboid morphologyMetastatic breast cancer cellsCancer cell migrationCytoskeletal functionECM protein concentrationMigration phenotypeAmoeboid migrationCell transitionMesenchymal migrationBiochemical cuesBreast cancer cellsCell migrationExtracellular matrixRounded morphologyBiphasic dependencePlate formatCollagen ICellsBiomaterial platform