2024
Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents.
Menezes M, Burroughs C, Pappagianopoulos J, Sadikova E, Fuhrmann E, Bohac G, Cross R, Witte L, Brinkmann G, Lemley R, Sukhodolsky D, Mazurek M. Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents. Autism 2024, 13623613241252470. PMID: 38764234, DOI: 10.1177/13623613241252470.Peer-Reviewed Original ResearchDepressive symptomsAutistic youthAutistic adolescentsEfficacy of behavioral activationTreatment of depressive symptomsYouth depressive symptomsTreatment of depressionAnxiety symptomsIntellectual disabilityBehavioral activationTherapy sessionsSocial skillsAutistic young peopleDepressionEfficacious treatmentPreliminary efficacySymptomsYouthAdolescentsQuality of lifePsychotherapyAnxietyYoung peopleDay-to-dayDisability
2018
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
Lewis AS, van Schalkwyk GI, Lopez MO, Volkmar FR, Picciotto MR, Sukhodolsky DG. An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2018, 48: 2748-2757. PMID: 29536216, PMCID: PMC6394231, DOI: 10.1007/s10803-018-3536-7.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderTransdermal nicotineDouble-blind crossover trialAggressive behaviorPreliminary efficacyAggressive symptomsSleep ratingsAggressionSubscale changesNicotinic acetylcholine receptorsNAChR agonistsPrimary outcomeNicotine treatmentCrossover trialExploratory trialΑ7 nAChRsAcetylcholine receptorsNicotineAdultsDisordersPlaceboNAChRsFurther investigationTrials
2017
Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders
Murphy TK, Fernandez TV, Coffey BJ, Rahman O, Gavaletz A, Hanks CE, Tillberg CS, Gomez LI, Sukhodolsky DG, Katsovich L, Scahill L. Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 762-770. PMID: 28723227, DOI: 10.1089/cap.2017.0024.Peer-Reviewed Original ResearchConceptsExtended-release guanfacineLack of efficacyChronic tic disorderGuanfacine groupPlacebo groupYGTSS total scoreAdverse eventsTotal scoreTic disordersYale Global Tic Severity Scale total scoreClinical Global Impressions-Improvement scaleCommon adverse eventsPlacebo-controlled trialKey secondary outcomesPrimary outcome measureLarger efficacy trialScale total scoreDry mouthSecondary outcomesPreliminary efficacyWeek 8Efficacy trialsOutcome measuresTic severityTourette's disorder