2024
Effect of empiric antibiotics against Pseudomonas aeruginosa on mortality in hospitalized patients: a systematic review and meta-analysis
Hunter C, Marhoffer E, Holleck J, Alshaeba S, Grimshaw A, Chou A, Carey G, Gunderson C. Effect of empiric antibiotics against Pseudomonas aeruginosa on mortality in hospitalized patients: a systematic review and meta-analysis. Journal Of Antimicrobial Chemotherapy 2024, dkae422. PMID: 39656468, DOI: 10.1093/jac/dkae422.Peer-Reviewed Original ResearchPrevalence of P. aeruginosaEffects of empiric antibioticsEmpirical antibioticsUrinary tract infectionSoft tissue infectionsCommunity-acquired pneumoniaTract infectionsTissue infectionsP. aeruginosaMortality benefitHospitalized patientsPseudomonas aeruginosaPooled adjusted ORP. aeruginosa infectionType of infectionStudy of patientsAbsolute mortality benefitIntensive care settingSystematic literature searchNosocomial pneumoniaSeptic shockMeaningful benefitAdjusted ORWeb of ScienceCompare mortality rates
2023
Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis
Carey G, Holleck J, Alshaeba S, Jayakrishnan R, Gordon K, Grimshaw A, Gunderson C. Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis. Journal Of Antimicrobial Chemotherapy 2023, 78: 1150-1159. PMID: 36964648, DOI: 10.1093/jac/dkad078.Peer-Reviewed Original ResearchConceptsCommon infectious syndromesEmpirical antibioticsPrevalence of MRSAInfectious syndromesMRSA infectionIll patientsMortality rateSystematic reviewAbsolute mortality benefitAnti-MRSA therapyEmpirical antibiotic coverageLow-risk infectionsSoft tissue infectionsUrinary tract infectionAbsolute risk reductionMethicillin-resistant Staphylococcus aureusCatheter-related infectionsStudy of patientsBaseline mortality ratesSystematic literature searchWeb of ScienceMRSA coverageAntibiotic coverageEmpirical antimicrobialsMortality benefit