Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform
Schultze A, Walker AJ, MacKenna B, Morton CE, Bhaskaran K, Brown JP, Rentsch CT, Williamson E, Drysdale H, Croker R, Bacon S, Hulme W, Bates C, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, Tomlinson L, Mathur R, Wing K, Wong AYS, Forbes H, Parry J, Hester F, Harper S, Evans SJW, Quint J, Smeeth L, Douglas IJ, Goldacre B, Collaborative O. Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform. The Lancet Respiratory Medicine 2020, 8: 1106-1120. PMID: 32979987, PMCID: PMC7515601, DOI: 10.1016/s2213-2600(20)30415-x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdolescentAdrenal Cortex HormonesAdultAgedAged, 80 and overAsthmaBetacoronavirusCohort StudiesCoronavirus InfectionsCOVID-19Electronic Health RecordsEnglandFemaleHumansMaleMiddle AgedMuscarinic AntagonistsPandemicsPneumonia, ViralProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRegression AnalysisSARS-CoV-2Young AdultConceptsChronic obstructive pulmonary diseaseCOVID-19-related deathsIndex dateObstructive pulmonary diseaseElectronic health recordsOpenSAFELY platformRespiratory medicationsCOPD cohortHazard ratioPulmonary diseaseAsthma cohortPrimary care electronic health recordsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2High-dose ICSHigh-dose ICSsRegular ICS useΒ-agonistsObservational cohort studyUK Medical Research CouncilRisk of deathCox regression modelAcute respiratory diseaseSyndrome coronavirus 2Factors associated with COVID-19-related death using OpenSAFELY
Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, MacKenna B, Tomlinson L, Douglas IJ, Rentsch CT, Mathur R, Wong AYS, Grieve R, Harrison D, Forbes H, Schultze A, Croker R, Parry J, Hester F, Harper S, Perera R, Evans SJW, Smeeth L, Goldacre B. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020, 584: 430-436. PMID: 32640463, PMCID: PMC7611074, DOI: 10.1038/s41586-020-2521-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAged, 80 and overAgingAsian PeopleAsthmaBetacoronavirusBlack PeopleCohort StudiesCoronavirus InfectionsCOVID-19Diabetes MellitusFemaleHumansHypertensionMaleMiddle AgedPandemicsPneumonia, ViralProportional Hazards ModelsRisk AssessmentSARS-CoV-2Sex CharacteristicsSmokingState MedicineYoung AdultConceptsCOVID-19-related deathsPrimary care electronic health recordsPrimary care recordsLarge cohort studyCoronavirus disease 2019Electronic health recordsSevere asthmaCohort studyClinical factorsSouth Asian peopleSevere outcomesDisease 2019Medical conditionsHigh riskOpenSAFELYWhite ethnicityCare recordsNHS EnglandPatient recordsPatient dataHealth recordsDeathGreater ageAsian peopleRisk