2024
Androgen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration?
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Androgen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration? American Journal Of Cancer Research 2024, 14: 3652-3664. PMID: 39113873, PMCID: PMC11301281, DOI: 10.62347/wola8904.Peer-Reviewed Original ResearchFrontopolar cortexCortical thicknessWorking memoryAndrogen deprivation therapyN-back performanceN-back taskProstate cancer patientsYears of educationPublished routinesNeural consequencesBrain changesBrain morphologyMediation analysisCT changesConsequences of androgen deprivation therapyMonths of androgen deprivation therapyTestosterone level changesImpact of androgen deprivation therapyCancer patientsNon-metastatic prostate cancerTestosterone levelsResponse to androgen deprivationLong duration of treatmentBrain imagingNeurodegenerative changes
2022
Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients.
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients. American Journal Of Cancer Research 2022, 12: 4802-4814. PMID: 36381311, PMCID: PMC9641391.Peer-Reviewed Original ResearchAndrogen deprivation therapyProstate cancer patientsWhite matter integrityCancer patientsAndrogen deprivationFractional anisotropyNon-metastatic prostate cancerSignificant FA changesImpaired white matter integrityPosterior corona radiataAnterior thalamic radiationDiffusion tensor imagingADT patientsDeprivation therapyProspective studyCorpus callosumProstate cancerCorona radiataYears of educationThalamic radiationPatientsWhole brainCognitive deficitsCognitive functionTensor imagingHypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients
Chaudhary S, Roy A, Summers C, Zhornitsky S, Ahles T, Li CR, Chao HH. Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients. Scientific Reports 2022, 12: 9567. PMID: 35688928, PMCID: PMC9187668, DOI: 10.1038/s41598-022-13361-4.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsQuality of lifeCancer patientsCorrect response rateMonths of ADTLong-term androgen deprivation therapyResponse rateNon-metastatic prostate cancerMontreal Cognitive Assessment scoreProspective observational studyState functional connectivityCognitive Assessment scoreDeprivation therapyHypothalamic connectivityAndrogen deprivationPrognostic markerProstate cancerGonadal axisObservational studyYears of educationQOL effectsControl groupQoLSalience networkThe effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity
Chaudhary S, Zhornitsky S, Roy A, Summers C, Ahles T, Li C, Chao HH. The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity. Cancer Medicine 2022, 11: 3425-3436. PMID: 35315585, PMCID: PMC9487881, DOI: 10.1002/cam4.4704.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyMid-cingulate cortexEffects of ADTFunctional connectivityPrecentral gyrusN-back taskN-back performanceState functional connectivityMontreal Cognitive Assessment scoreHypothalamic functional connectivityProspective observational studyNonmetastatic prostate cancerProstate cancer patientsCognitive Assessment scoreQuality of lifeSustain attentionAffective functionsDeprivation therapyHypothalamic connectivityYears of educationAndrogen deprivationCorrect response rateQOL scoresCancer patientsClinical correlates
2007
Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men
Li CS, Huang C, Yan P, Bhagwagar Z, Milivojevic V, Sinha R. Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men. Neuropsychopharmacology 2007, 33: 1798-1806. PMID: 17895916, PMCID: PMC2731999, DOI: 10.1038/sj.npp.1301568.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexCocaine-dependent menFunctional magnetic resonance imagingCocaine dependenceResponse inhibitionNeural correlatesHealthy control subjectsRisk of relapsePre-supplementary motor areaSubstance use disordersAnterior cingulate cortexImpulse controlSignal inhibitionMagnetic resonance imagingUseful neural markersStop-signal inhibitionRelative hypoactivationMale patientsControl subjectsSignal reaction timeMotor areaYears of educationUse disordersCingulate cortexResonance imaging
2006
Gender differences in the neural correlates of response inhibition during a stop signal task
Li CS, Huang C, Constable RT, Sinha R. Gender differences in the neural correlates of response inhibition during a stop signal task. NeuroImage 2006, 32: 1918-1929. PMID: 16806976, DOI: 10.1016/j.neuroimage.2006.05.017.Peer-Reviewed Original ResearchConceptsStop-signal taskBrain activationResponse inhibitionGreater activationSignal taskAnterior cingulate cortexRegional brain activationNeural correlatesCognitive-motor tasksGender differencesFunctional magnetic resonanceStop-signal inhibitionMotor thalamusGlobus pallidusSubcortical areasYears of educationMotor circuitryCingulate cortexBrain regionsCaudate tailMotor tasksWomenSuccess rateLower statistical thresholdMen