2023
Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders
Zhu T, Wang W, Chen Y, Kranzler H, Li C, Bi J. Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 326-336. PMID: 37696489, PMCID: PMC10976073, DOI: 10.1016/j.bpsc.2023.08.010.Peer-Reviewed Original ResearchNicotine use disorderHealthy controlsFunctional connectivity featuresUse disordersMagnetic resonance imagingNUD subjectsVisual cortexResonance imagingClinical metricsFunctional connectivityNoninvasive toolNeural phenotypesSample of individualsMulti-task learningTransdiagnostic approachUK BiobankReplication setGenetic profileMarkersReplication sampleHighest areaDisordersDepressionAUDBody of literature
2021
Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2019
Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence
Zhang S, Zhornitsky S, Le TM, Li CR. Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence. The International Journal Of Neuropsychopharmacology 2019, 22: 754-764. PMID: 31420667, PMCID: PMC6929672, DOI: 10.1093/ijnp/pyz044.Peer-Reviewed Original ResearchConceptsHealthy control participantsHypothalamic activationCocaine useCocaine-dependent participantsFood cuesCocaine addictionHypothalamic responseControl participantsCocaine Craving QuestionnaireRecent cocaine useFunctional magnetic resonance imagingMagnetic resonance imagingCue-related activationsInferior parietal cortexHypothalamic dysfunctionClinical variablesDopaminergic pathwaysTonic cravingFood intakeQuestionnaire scoresRodent studiesVisual cortexParietal cortexResonance imagingHypothalamus
2018
Hypothalamic response to cocaine cues and cocaine addiction severity
Zhang S, Zhornitsky S, Angarita GA, Li C. Hypothalamic response to cocaine cues and cocaine addiction severity. Addiction Biology 2018, 25: e12682. PMID: 30295396, PMCID: PMC6453736, DOI: 10.1111/adb.12682.Peer-Reviewed Original ResearchConceptsCocaine Craving QuestionnaireCocaine Selective Severity AssessmentFunctional magnetic resonance imagingCocaine-dependent individualsAddiction severityOrbitofrontal cortexHypothalamic responseVentral striatumCocaine addictionCocaine cuesAngular gyrusBilateral orbitofrontal cortexBilateral visual cortexCue-induced cravingMagnetic resonance imagingMiddle frontal gyrusClinical featuresNeutral cuesDopaminergic circuitsHypothalamusVisual cortexResonance imagingDopaminergic midbrainFrontal gyrusAg responseFrom eyes‐closed to eyes‐open: Role of cholinergic projections in EC‐to‐EO alpha reactivity revealed by combining EEG and MRI
Wan L, Huang H, Schwab N, Tanner J, Rajan A, Lam NB, Zaborszky L, Li C, Price CC, Ding M. From eyes‐closed to eyes‐open: Role of cholinergic projections in EC‐to‐EO alpha reactivity revealed by combining EEG and MRI. Human Brain Mapping 2018, 40: 566-577. PMID: 30251753, PMCID: PMC6338213, DOI: 10.1002/hbm.24395.Peer-Reviewed Original ResearchConceptsRole of acetylcholineAlpha reactivityOlder adultsVisual cortexYoung adultsFunctional connectivity increasesAlpha desynchronizationCortical acetylcholineCholinergic pathwaysCholinergic projectionsLeukoaraiosis volumeCholinergic systemBasal nucleusPosterior cortexFunctional MRICohortFunctional connectivityCognitive healthAcetylcholineConnectivity increasesSimultaneous EEG-fMRIAlpha rhythmCortexAdultsSeparate sessionsVentral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity
Zhang S, Li CR. Ventral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity. Translational Psychiatry 2018, 8: 119. PMID: 29915214, PMCID: PMC6006289, DOI: 10.1038/s41398-018-0164-0.Peer-Reviewed Original ResearchConceptsState functional connectivityCocaine dependenceVentral striatumFunctional connectivityVentral striatal dysfunctionExtent of depressionCircuit deficitsDopaminergic deficitFunctional dysconnectivityStriatal dysfunctionRSFC differencesVmPFC connectivitySubregional changesRsFC changesParahippocampal gyrusCocaine cravingCortical connectivityHealthy populationVentromedial prefrontal cortexVisual cortexMental illnessCocaine useRSFCPrefrontal cortexFunctional subregions
2008
Neural Correlates of Speeded as Compared with Delayed Responses in a Stop Signal Task: An Indirect Analog of Risk Taking and Association with an Anxiety Trait
Li CS, Chao H, Lee TW. Neural Correlates of Speeded as Compared with Delayed Responses in a Stop Signal Task: An Indirect Analog of Risk Taking and Association with an Anxiety Trait. Cerebral Cortex 2008, 19: 839-848. PMID: 18678764, PMCID: PMC2722793, DOI: 10.1093/cercor/bhn132.Peer-Reviewed Original ResearchConceptsStop-signal taskSignal taskReaction timeTrial reaction timeStop-signal performanceFunctional magnetic resonanceMiddle frontal gyrusAdvantage of variabilityBilateral visual cortexPosterior cingulate cortexCognitive controlNeural correlatesNeural processesAmygdala activityTrait anxietyFrontal gyrusAnxiety traitsBehavioral paradigmsIndirect analogueCingulate cortexNeural analogRisk takingVisual cortexStop signalCurrent study