2020
Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocaine
2019
Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers
Wang W, Zhornitsky S, Le TM, Zhang S, Li CR. Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 619-628. PMID: 32061544, PMCID: PMC7286768, DOI: 10.1016/j.bpsc.2019.12.013.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestProblem alcohol useHeart rate variabilityCue exposureAlcohol useAUDIT scoresAutonomic responsesRate variabilityNeutral cue exposureCue exposure paradigmDisorders Identification TestAlcohol cue exposurePrefrontal cortical responsesVentromedial prefrontal cortex activityAlcohol drinkersPrefrontal cortex activityHigher RMSSDCortical responsesParasympathetic responseAlcohol cravingAlcohol misuseVentromedial prefrontal cortexExposure paradigmCortex activityMediation analysisCue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activity