Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
Canessa C, Schild L, Buell G, Thorens B, Gautschi I, Horisberger J, Rossier B. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 1994, 367: 463-467. PMID: 8107805, DOI: 10.1038/367463a0.Peer-Reviewed Original ResearchConceptsEpithelial sodium channelRat epithelial sodium channelSodium channelsSodium reabsorptionSodium balanceDistal colonAmiloride-sensitive epithelial sodium channelPharmacological profileBlood volumeRenal tubulesRat epithelialExocrine glandsEpithelial cellsΑ-subunitDistal partNative channelsExpression cloningAldosteroneLungColonChapter 4 Structure–Function Relationship of Na,K-ATPase: The Digitalis Receptor
Canessa C, Jaisser F, Horisberger J, Rossier B. Chapter 4 Structure–Function Relationship of Na,K-ATPase: The Digitalis Receptor. Current Topics In Membranes 1994, 41: 71-85. DOI: 10.1016/s0070-2161(08)60454-2.Peer-Reviewed Original ResearchStructure-function relationshipsAmino acidsFirst transmembrane domainSite-directed mutagenesisK-ATPaseAmino acid residuesOuabain-sensitive cellsFunctional mutantsTransmembrane domainCellular processesDrug-binding sitesAromatic amino acidsDigitalis receptorWild typeContact sitesRandom mutationsOuabain resistanceΑ-subunitAcid residuesSite-specific ligandsFunctional assaysCardiac glycosidesCell linesOuabain analoguesK-ATPase activity