2020
Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults
Trelle AN, Carr VA, Guerin SA, Thieu MK, Jayakumar M, Guo W, Nadiadwala A, Corso NK, Hunt MP, Litovsky CP, Tanner NJ, Deutsch GK, Bernstein JD, Harrison MB, Khazenzon AM, Jiang J, Sha SJ, Fredericks CA, Rutt BK, Mormino EC, Kerchner GA, Wagner AD. Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. ELife 2020, 9: e55335. PMID: 32469308, PMCID: PMC7259949, DOI: 10.7554/elife.55335.Peer-Reviewed Original ResearchConceptsHippocampal pattern completionCortical reinstatementEpisodic memoryHippocampal activityOlder adultsPattern completionAge-related episodic memory declineTrial-unique associationsTrial-wise analysesEpisodic memory declineNormal older adultsEpisodic rememberingFMRI indicesMemory variabilityIndividual differencesUnique varianceAssociative retrievalMemory declineCortical mechanismsFMRI dataReinstatementMemoryAdultsRetrievalRemembering
2018
Early affective changes and increased connectivity in preclinical Alzheimer's disease
Fredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, Resnick SM, Seeley WW. Early affective changes and increased connectivity in preclinical Alzheimer's disease. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2018, 10: 471-479. PMID: 30302368, PMCID: PMC6174255, DOI: 10.1016/j.dadm.2018.06.002.Peer-Reviewed Original ResearchAffective changesEmotional reactivityPreclinical Alzheimer's diseaseInterpersonal warmthSocial-emotional processingEnhanced emotional reactivitySuperior temporal sulcusNormal older adultsSalience network connectivityHigher functional connectivityAmyloid-positive individualsHigh global connectivityMild Alzheimer's diseaseTemporal sulcusSalience networkSignificant stimuliRight insulaFunctional connectivityCognitive declineOlder adultsAffective symptomsAlzheimer's diseaseLongitudinal assessmentKey regionsWarmth