2010
REVIEW PAPER: Animals as Models of Age-Related Macular Degeneration
Zeiss CJ. REVIEW PAPER: Animals as Models of Age-Related Macular Degeneration. Veterinary Pathology 2010, 47: 396-413. PMID: 20382825, DOI: 10.1177/0300985809359598.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationMacular degenerationRelevant mouse modelNonhuman primate modelCause of blindnessRetinal pigment epitheliumMajority of casesEtiologic complexityAMD pathologyChoroidal neovascularizationEtiologic factorsModel of agePrimate modelRodent retinaPathogenetic mechanismsMouse modelGenetic predispositionSalient anatomyPigment epitheliumAnimal modelsDegenerative conditionsComplement activationLipid metabolismBruch's membraneGene function
2007
Motor deficits and altered striatal gene expression in aphakia (ak) mice
Singh B, Wilson JH, Vasavada HH, Guo Z, Allore HG, Zeiss CJ. Motor deficits and altered striatal gene expression in aphakia (ak) mice. Brain Research 2007, 1185: 283-292. PMID: 17949697, PMCID: PMC3904435, DOI: 10.1016/j.brainres.2007.09.006.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaMonths of lifeAK miceWT miceParkinson's diseaseMotor performanceStriatal gene expressionDopaminergic denervationNigrostriatal dysfunctionStriatal denervationMotor deficitsPars compactaMotor abnormalitiesAphakia miceMice progressMotor functionStriatal transcriptomeDRD2 expressionPole testWT controlsSemi-quantitative RT-PCRAge groupsMiceRT-PCRTime points