2019
Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans
Zeiss CJ, Gatti DM, Toro-Salazar O, Davis C, Lutz CM, Spinale F, Stearns T, Furtado MB, Churchill GA. Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans. G3: Genes, Genomes, Genetics 2019, 9: 2637-2646. PMID: 31263061, PMCID: PMC6686936, DOI: 10.1534/g3.119.400232.Peer-Reviewed Original ResearchConceptsCardiac diseaseCardiac pathologyCardiac troponin I levelsUltimate severityChronic cardiac injuryTroponin I levelsPotential predictive biomarkersDoxorubicin-Induced CardiotoxicityComplete blood countPanel of biomarkersCurrent mouse modelsEffect of treatmentCardiac troponin IProgressive cardiotoxicityLight chain 3Acute periodAcute phaseCardiac injuryRenal toxicityBlood countPredictive biomarkersChronic timepointsCollaborative Cross miceSame doseI levels
2004
Proliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse
Zeiss CJ, Johnson EA. Proliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse. Investigative Ophthalmology & Visual Science 2004, 45: 971-976. PMID: 14985319, DOI: 10.1167/iovs.03-0301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkersCDC2-CDC28 KinasesCell Cycle ProteinsCell DivisionCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent KinasesDNA ReplicationImmunohistochemistryIn Situ Nick-End LabelingKi-67 AntigenMiceMice, Inbred C57BLMice, Mutant StrainsMicrogliaPhotoreceptor Cells, VertebrateProliferating Cell Nuclear AntigenProto-Oncogene ProteinsRetinal DegenerationConceptsOuter nuclear layerTerminal dUTP transferase nick end labelingNuclear layerCell cycle progressionMicroglial cellsPhotoreceptor deathCycle progressionProliferation of microgliaNick end labelingCell nuclear antigenControl miceNeurotrophic factorPeripheral gradientInner retinaNeuronal deathCell cycle proteinsPhotoreceptor lossRD-1Ki-67Postnatal dayPreexisting conditionsNeurodegenerative conditionsDouble immunolabelingBromodeoxyuridine uptakePhotoreceptor apoptosis