2024
Modeling lung adenocarcinoma metastases using patient-derived organoids
Liu Y, Lankadasari M, Rosiene J, Johnson K, Zhou J, Bapat S, Chow-Tsang L, Tian H, Mastrogiacomo B, He D, Connolly J, Lengel H, Caso R, Dunne E, Fick C, Rocco G, Sihag S, Isbell J, Bott M, Li B, Lito P, Brennan C, Bilsky M, Rekhtman N, Adusumilli P, Mayo M, Imielinski M, Jones D. Modeling lung adenocarcinoma metastases using patient-derived organoids. Cell Reports Medicine 2024, 5: 101777. PMID: 39413736, PMCID: PMC11513837, DOI: 10.1016/j.xcrm.2024.101777.Peer-Reviewed Original ResearchConceptsMetastasis modelLung adenocarcinomaAutologous peripheral blood mononuclear cellsEarly-stage lung cancerMechanisms of drug resistancePeripheral blood mononuclear cellsBlood mononuclear cellsEfficacy of treatmentLung cancer metastasisLung adenocarcinoma metastasisDistant metastasisStudy clonalityAdenocarcinoma metastasisLung cancerMononuclear cellsDrug resistanceMetastasisSuppress metastasisIndividual patientsTumor evolutionCancer metastasisHuman metastasesPatientsBiological featuresRNA sequencingLate Recurrence of Completely Resected Stage I-IIIA Lung Adenocarcinoma
Fick C, Dunne E, Toumbacaris N, Tan K, Mastrogiacomo B, Park B, Adusumilli P, Molena D, Gray K, Sihag S, Huang J, Bott M, Rocco G, Isbell J, Jones D. Late Recurrence of Completely Resected Stage I-IIIA Lung Adenocarcinoma. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 38950771, DOI: 10.1016/j.jtcvs.2024.06.026.Peer-Reviewed Original ResearchAggressive pathological featuresLate recurrenceLung adenocarcinomaFollow-upPathological featuresAssociated with late recurrenceElevated risk of recurrenceFactors associated with late recurrenceRetrospective analysis of patientsRecurrence of lung adenocarcinomaHistory of lung cancerStage IIIA diseaseTime of resectionRisk of recurrenceAnalysis of patientsGenomic mutationsNeoadjuvant therapyIIIA diseaseEarly recurrenceClinicopathological variablesLogistic regression modelsRetrospective analysisLung cancerRecurrencePatients
2019
Melorheostosis
Fick CN, Fratzl-Zelman N, Roschger P, Klaushofer K, Jha S, Marini JC, Bhattacharyya T. Melorheostosis. The American Journal Of Surgical Pathology 2019, 43: 1554-1559. PMID: 31386640, PMCID: PMC7832124, DOI: 10.1097/pas.0000000000001310.Peer-Reviewed Original ResearchConceptsClinical presentationBone biopsyCortical bone depositionProminent cement linesPatient's clinical presentationCommon histologic findingsRadiologic patternsPathologic findingsRadiographic findingsHistologic patternHistologic findingsDifferential diagnosisBone diseaseDripping candle waxDense cortical boneMelorheostosisPatientsMultiple patientsClinical pathologistsBone depositionCortical boneBiopsyDiagnosisDistinct patternsBoneOptimal timing of delayed excretory phase computed tomography scan for diagnosis of urinary extravasation after high-grade renal trauma
Keihani S, Putbrese BE, Rogers DM, Patel DP, Stoddard GJ, Hotaling JM, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller B, Santucci RA, Carrick MM, Kocik JF, Hewitt T, Burks FN, Heilbrun ME, Myers JB. Optimal timing of delayed excretory phase computed tomography scan for diagnosis of urinary extravasation after high-grade renal trauma. Journal Of Trauma And Acute Care Surgery 2019, 86: 274-281. PMID: 30605143, DOI: 10.1097/ta.0000000000002098.Peer-Reviewed Original ResearchConceptsHigh-grade renal traumaInitial CT scanUrinary extravasationRenal collecting system injuryRenal traumaExcretory phaseCT scanSystem injuryTomography scanOptimal timingPhase CT scansInitial CTMedian timeLevel ICutoff pointExtravasationPoisson regressionLevel IIIAccurate diagnosisDiagnosisPhase timingAccurate gradingTraumaScansPatients
2011
Medical marijuana: Medical necessity versus political agenda
Clark PA, Capuzzi K, Fick C. Medical marijuana: Medical necessity versus political agenda. Medical Science Monitor 2011, 17: ra249-ra261. PMID: 22129912, PMCID: PMC3628147, DOI: 10.12659/msm.882116.Peer-Reviewed Original ResearchConceptsDrug Enforcement AgencyChronic non-cancer painNon-cancer painMedical marijuanaSchedule II drugsBenefits of marijuanaMultiple sclerosisMuscle spasmSchedule I drugBeneficial treatmentWasting syndromePatientsMedical necessityDistrict of ColumbiaDrugsMarijuanaPhysiciansRelevant scientific dataRecent studiesMedical useVomitingNauseaPainSpasmChemotherapy