2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2020
Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
Benveniste H, Lee H, Ozturk B, Chen X, Koundal S, Vaska P, Tannenbaum A, Volkow ND. Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging. Neuroscience 2020, 474: 63-79. PMID: 33248153, PMCID: PMC8149482, DOI: 10.1016/j.neuroscience.2020.11.014.Peer-Reviewed Original Research