2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2021
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics
Ozturk BO, Monte B, Koundal S, Dai F, Benveniste H, Lee H. Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics. Fluids And Barriers Of The CNS 2021, 18: 1. PMID: 33407650, PMCID: PMC7788828, DOI: 10.1186/s12987-020-00236-x.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingApparent diffusion coefficientCerebrospinal fluidGlymphatic transportSprague-Dawley female ratsLow-dose isofluraneCrossover study designRepetitive magnetic resonance imagingDawley female ratsTissue compartmentsVolume statusAnesthesia groupBasal cisternsDiffusion-weighted imagesDexmFemale ratsParenchymal expansionHeart rateGlymphatic systemDifferent anestheticsIsofluraneTissue statusResonance imagingFluid shiftsCSF compartment