A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use
McCurdy L, Kong G, Krishnan-Sarin S, Kiluk B, Potenza M. A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use. PLOS ONE 2023, 18: e0292293. PMID: 37796784, PMCID: PMC10553253, DOI: 10.1371/journal.pone.0292293.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansNon-Randomized Controlled Trials as TopicPilot ProjectsQuality of LifeSocial SupportConceptsRecovery support servicesHazardous alcohol useSocial support interventionsAlcohol usePilot studyEarly recoverySupport interventionsPilot study protocolMixed methods pilot studyOnline social support interventionQuality of lifeSupport servicesSelf-reported changesPrimary outcomeSecondary outcomesStudy protocolHazardous alcoholClinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder
Kiluk B, Kleykamp B, Comer S, Griffiths R, Huhn A, Johnson M, Kampman K, Pravetoni M, Preston K, Vandrey R, Bergeria C, Bogenschutz M, Brown R, Dunn K, Dworkin R, Finan P, Hendricks P, Houtsmuller E, Kosten T, Lee D, Levin F, McRae-Clark A, Raison C, Rasmussen K, Turk D, Weiss R, Strain E. Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder. JAMA Psychiatry 2023, 80: 84-92. PMID: 36449315, PMCID: PMC10297827, DOI: 10.1001/jamapsychiatry.2022.4020.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD treatmentUse disordersClinical trial design challengesAddiction Clinical Trial TranslationsΜ-opioid receptor systemNetworks (ACTTION) public-private partnershipTrial design challengesOngoing opioid epidemicTrial design considerationsClinical trial design considerationsRole of treatmentQuality of lifeAntagonist medicationsEmerging TreatmentsAdverse eventsOpioid usePrimary outcomeStages of treatmentPatient preferencesMOR agonistsOpioid epidemicConsensus recommendationsCurrent evidenceTreatment retention