2024
Promoting Race and Ethnic Diversity in a Hospital-Based Randomized Clinical Trial to Address Untreated Alcohol Use Disorder: Initial Lessons Learned.
Edelman E, Frankforter T, Rojas-Perez O, Ablondi K, Castro C, Corvino J, Garcia I, Gordon D, Jaramillo Y, Johnson N, Jordan A, Nich C, Paris M, Pagano D, Weimer M, Williams E, Kiluk B. Promoting Race and Ethnic Diversity in a Hospital-Based Randomized Clinical Trial to Address Untreated Alcohol Use Disorder: Initial Lessons Learned. Journal Of Addiction Medicine 2024 PMID: 39514895, DOI: 10.1097/adm.0000000000001400.Peer-Reviewed Original ResearchAlcohol use disorderBrief Negotiation InterviewUntreated alcohol use disorderUse disorderSocial determinants of healthCognitive behavioral therapyElectronic medical record dataDeterminants of healthEthnically diverse sampleMedical record dataMonths of recruitmentBehavioral therapyModifications-EnhancedReporting AdaptationsTreatment engagementEffectiveness of strategiesSocial determinantsInitiation of medicationRecruitment approachesDiverse samplePost-hospitalizationAlcohol useResearch staffParent trialRecord dataImprovement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial
Benitez B, Loya J, Jaramillo Y, Muro-Rodriguez N, Rojas Perez O, Nich C, Frankforter T, Paris M, Kiluk B. Improvement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial. Journal Of Substance Use And Addiction Treatment 2024, 168: 209536. PMID: 39374899, DOI: 10.1016/j.josat.2024.209536.Peer-Reviewed Original ResearchMechanisms of cognitive behavioral therapyQuality of coping skillsCognitive behavioral therapySubstance use disordersPrimary substance useCoping skillsSubstance useCBT programOutpatient treatmentWeeks of outpatient treatmentDigital cognitive behavioral therapyMechanisms of behavior changeWithin-person increasesDaily substance useAdaptive coping skillsSecondary analysis of clinical trial dataTreatment mechanismsRandomized to 8Associated with reductionsBehavioral therapyAnalysis of clinical trial dataUse disorderGeneralizability of researchSecondary analysisSpanish-speaking Hispanic adultsA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellum
2023
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersThe Effect of Cognitive Behavioral Therapy on Impulsivity in Addictive Disorders: a Narrative Review
Loya J, Benitez B, Kiluk B. The Effect of Cognitive Behavioral Therapy on Impulsivity in Addictive Disorders: a Narrative Review. Current Addiction Reports 2023, 10: 485-493. PMID: 38269068, PMCID: PMC10805411, DOI: 10.1007/s40429-023-00491-6.Peer-Reviewed Original ResearchCognitive behavioral therapyBehavioral therapySubstance useAddictive disordersFuture clinical trialsPoor treatment outcomesEvidence-based treatmentsMeasures of impulsivityCycle of addictionCBT effectsRisk factorsClinical trialsTreatment outcomesRecent FindingsThereNarrative reviewCharacteristics of addictionLimited evidenceRange of addictionsAssessment of impulsivityTherapyAddictionTrialsDisordersImpulsivityAddictive behaviorsEfficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate?
Magill M, Kiluk B, Ray L. Efficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate? Substance Abuse And Rehabilitation 2023, 14: 1-11. PMID: 36844999, PMCID: PMC9948631, DOI: 10.2147/sar.s362864.Peer-Reviewed Original ResearchUsual care control conditionCare control conditionDrug use disordersUse disordersEvidence-based treatmentsCognitive behavioral therapyMechanism of actionCBT effectsControl conditionDemonstrated efficacyCBT efficacyForm of CBTBehavioral therapyTherapy efficacyAdult alcoholAOD useMotivational interviewingNarrative overviewContingency managementEfficacyIntervention outcomesTraditional CBTCBTPreliminary evidenceEffect sizePromoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2022
Computer-based training for cognitive behavioral therapy for Spanish-speaking substance users: adaptation and satisfaction
Silva M, Añez L, Carroll K, Jaramillo Y, Kiluk B, Frankforter T, Ball S, Gordon M, Paris M. Computer-based training for cognitive behavioral therapy for Spanish-speaking substance users: adaptation and satisfaction. Journal Of Ethnicity In Substance Abuse 2022, 23: 251-271. PMID: 35714996, PMCID: PMC10350903, DOI: 10.1080/15332640.2022.2086194.Peer-Reviewed Original ResearchComputer-based trainingCognitive-behavioral skills trainingCognitive behavioral therapy programSubstance useBehavioral therapy programCognitive behavioral therapyBehavioral health interventionsBehavioral therapySkills trainingMonolingual SpanishSubstance usersLife experiencesTherapy programProgram contentCultural adaptationSpanishTrainingSatisfactionHealth interventionsAdultsCBT4CBTHigh levelsParticipantsAdaptationIntervention
2021
A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy
Kacmarek CN, Yates BT, Nich C, Kiluk BD. A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy. Alcohol Clinical And Experimental Research 2021, 45: 1109-1121. PMID: 33730384, PMCID: PMC8131237, DOI: 10.1111/acer.14601.Peer-Reviewed Original ResearchConceptsAlcohol use disorderIncremental cost-effective ratioCognitive behavioral therapyStandard outpatient treatmentPilot economic evaluationOutpatient treatmentTreatment costsUse disordersDrinking daysBehavioral therapyComputerized cognitive behavioral therapyEvidence-based treatmentsOutpatient treatment facilitiesTotal treatment costsCost of treatmentCost-effective ratioComputer-delivered interventionNet benefit analysisHealthcare utilizationCost-effective additionClinical trialsTreatment protocolCriminal justice involvementTraditional therapiesTreatment termination
2020
Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersCombined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders
Ray LA, Meredith LR, Kiluk BD, Walthers J, Carroll KM, Magill M. Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders. JAMA Network Open 2020, 3: e208279. PMID: 32558914, PMCID: PMC7305524, DOI: 10.1001/jamanetworkopen.2020.8279.Peer-Reviewed Original ResearchConceptsSubstance use disordersAdult alcohol use disordersCognitive behavioral therapyUsual careRandomized clinical trialsUse disordersBehavioral therapySpecific therapyClinical trialsAddition of CBTSuperiority of CBTTreatment of SUDsUsual clinical managementForms of pharmacotherapyFirst-line interventionEvidence-based therapiesClinical trial samplesEvidence-based modalitiesAlcohol use disorderEnglish-language articlesPublic health concernFull-text articlesEffect sizeCochrane RegisterRandom effects estimatesThe search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review
Magill M, Tonigan JS, Kiluk B, Ray L, Walthers J, Carroll K. The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review. Behaviour Research And Therapy 2020, 131: 103648. PMID: 32474226, PMCID: PMC7329023, DOI: 10.1016/j.brat.2020.103648.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersSystematic reviewBehavioral therapyRandomized clinical trialsStudy inclusion criteriaPatient behavior changeCBT-based treatmentClinical trialsInclusion criteriaStatistical mediatorMediator candidatesIntervention ingredientsProject MATCHCBT mechanismsTherapyBehavior change frameworkMediatorsBehavior changeDisordersAddiction researchReportReviewReview sampleShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increaseInitial testing of a computer-based simulation training module to support clinicians' acquisition of CBT skills for substance use disorder treatment
Mastroleo NR, Humm L, Williams CM, Kiluk BD, Hoadley A, Magill M. Initial testing of a computer-based simulation training module to support clinicians' acquisition of CBT skills for substance use disorder treatment. Journal Of Substance Use And Addiction Treatment 2020, 114: 108014. PMID: 32527511, PMCID: PMC7361509, DOI: 10.1016/j.jsat.2020.108014.Peer-Reviewed Original Research
2019
A Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition
Magill M, Ray L, Kiluk B, Hoadley A, Bernstein M, Tonigan JS, Carroll K. A Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition. Journal Of Consulting And Clinical Psychology 2019, 87: 1093-1105. PMID: 31599606, PMCID: PMC6856400, DOI: 10.1037/ccp0000447.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersEffect sizeConsumption frequencyTime pointsEvidence-based therapiesPooled effect sizeMinimal treatmentEstimates of efficacyTest of heterogeneityCBT effectsNonspecific therapySpecific therapySuperior efficacyStudy-level moderatorsModerate heterogeneityTreatment efficacySignificant effect sizeMultivariate analysisMeta-AnalysisTherapyPublication biasStudy aimNonspecific controlTechnology‐Delivered Cognitive‐Behavioral Interventions for Alcohol Use: A Meta‐Analysis
Kiluk BD, Ray LA, Walthers J, Bernstein M, Tonigan JS, Magill M. Technology‐Delivered Cognitive‐Behavioral Interventions for Alcohol Use: A Meta‐Analysis. Alcohol Clinical And Experimental Research 2019, 43: 2285-2295. PMID: 31566787, PMCID: PMC6824956, DOI: 10.1111/acer.14189.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyAlcohol usePerson cognitive-behavioural therapyEffect sizePooled effect sizeDelivery of CBTEvidence-based interventionsStand-alone treatmentMinimal treatment controlUsual careCognitive-behavioral interventionsSuperior efficacyClinical practiceTechnology-based deliveryHeavy drinkersMeta-AnalysisPsychiatric conditionsWeb-based programHeavy drinkingMotivational interviewingEfficacyTreatment controlInterventionWeighted effect sizeTherapyComputerized Cognitive Behavioral Therapy for Substance Use Disorders: A Summary of the Evidence and Potential Mechanisms of Behavior Change
Kiluk BD. Computerized Cognitive Behavioral Therapy for Substance Use Disorders: A Summary of the Evidence and Potential Mechanisms of Behavior Change. Perspectives On Behavior Science 2019, 42: 465-478. PMID: 31976445, PMCID: PMC6768920, DOI: 10.1007/s40614-019-00205-2.Peer-Reviewed Original ResearchCognitive behavioral therapySubstance use disordersTraditional cognitive behavioral therapyComputerized cognitive behavioral therapyBehavior changeSubstance useBehavioral coping skillsComputer-delivered interventionComputerized CBT programUse disordersMinimal clinical monitoringCBT programCoping skillsBehavioral therapyCBT mechanismsRates of alcoholConsiderable empirical evidenceBehavioral skillsBehavioral interventionsTheory-driven assumptionsDifferent treatment settingsNew skillsStrong supportEvaluation of individualsTreatment termination
2018
Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisordersRandomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes
Kiluk BD, Nich C, Buck MB, Devore KA, Frankforter TL, LaPaglia DM, Muvvala SB, Carroll KM. Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes. American Journal Of Psychiatry 2018, 175: 853-863. PMID: 29792052, PMCID: PMC6120780, DOI: 10.1176/appi.ajp.2018.17090978.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapySubstance use disordersComputer-based cognitive behavioral therapyUse disordersMinimal clinical monitoringTreatment-seeking populationTreatment-seeking outpatientsDSM-IV-TR criteriaCBT groupFrequency of substanceStandard outpatient careCBT4CBTStand-alone treatmentDiverse sampleStandard outpatient treatmentCurrent substance use disorderBehavioral conceptsBetter learningSubstance abuseHeterogeneous sampleUp OutcomesHigh dropout ratePrevious trialsSix-month followClinical trials