2021
Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner
Cathey A, Watkins D, Rosario Z, Vega C, Mukherjee B, O’Neill M, Loch-Caruso R, Alshawabkeh A, Cordero J, Meeker J. Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner. Frontiers In Endocrinology 2021, 12: 742145. PMID: 34603214, PMCID: PMC8479114, DOI: 10.3389/fendo.2021.742145.Peer-Reviewed Original ResearchConceptsTime of deliveryFetal sexBody mass indexGestational ageMaternal agePreterm premature rupture of membranesPre-pregnancy body mass indexHormone concentrationsFetal sex-specific effectsPremature rupture of membranesOverall preterm birthPreterm premature ruptureSpontaneous preterm laborRupture of membranesReduced gestational ageOdds of PTBTime of laborSignificant public health problemTobacco smoke exposureGestational hormonesSpontaneous PTBPreterm laborWeeks gestationPreterm birthLongitudinal birth cohort
2020
Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes
Salerno S, Zhao Z, Sankar S, Salvatore M, Gu T, Fritsche L, Lee S, Lisabeth L, Valley T, Mukherjee B. Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes. Journal Of Internal Medicine 2020, 289: 726-737. PMID: 33253457, PMCID: PMC7753604, DOI: 10.1111/joim.13213.Peer-Reviewed Original ResearchConceptsAssociated with repeat testingFalse-negative rateNeighborhood poverty levelPre-existing type 2 diabetesSevere COVID-19-related outcomesDiagnostic testsPatient characteristicsPre-existing kidney diseaseBody mass indexICU-level careHealth outcomesCOVID-19-related outcomesCharacteristics of patientsCOVID-19 diagnostic testsType 2 diabetesMichigan MedicineMass indexCOVID-19Pain symptomsPatient agePoverty levelDownstream outcomesKidney diseaseRepeated testingLiver diseaseAssociations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's HealthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
2017
Acculturation Strategies and Symptoms of Depression: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
Needham B, Mukherjee B, Bagchi P, Kim C, Mukherjea A, Kandula N, Kanaya A. Acculturation Strategies and Symptoms of Depression: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Journal Of Immigrant And Minority Health 2017, 20: 792-798. PMID: 28748299, PMCID: PMC5785586, DOI: 10.1007/s10903-017-0635-z.Peer-Reviewed Original ResearchConceptsSymptoms of depressionDepressive symptomsUS cultureSouth Asian immigrantsAcculturation strategiesElevated symptoms of depressionSocial supportSelf-reported social supportUndertreated mental disordersCES-D scaleAsian immigrantsSouth Asian culturesElevated symptomsLatent class analysisMental disordersCES-DIntegrated classesSouth AsiansMediators of AtherosclerosisAsian culturesDepressionLatent classesClass analysisAcculturationSymptomsMeta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies
Estes J, Rice J, Li S, Stringham H, Boehnke M, Mukherjee B. Meta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies. Statistics In Medicine 2017, 36: 3895-3909. PMID: 28744888, PMCID: PMC5624850, DOI: 10.1002/sim.7398.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-Ketoglutarate-Dependent Dioxygenase FTOBayes TheoremBiasBiometryBody Mass IndexCase-Control StudiesComputer SimulationDiabetes Mellitus, Type 2Gene-Environment InteractionHumansLogistic ModelsMeta-Analysis as TopicModels, GeneticModels, StatisticalPolymorphism, Single NucleotideRetrospective StudiesConceptsGene-environment independenceGene-environmentEmpirical Bayes estimatorsGene-environment interactionsCase-control studyMeta-analysis settingBayes estimatorsRetrospective likelihood frameworkShrinkage estimatorsMeta-analysisTesting gene-environment interactionsCombination of estimatesFactors body mass indexSimulation studyBody mass indexUnconstrained modelLikelihood frameworkInverse varianceMeta-analysis frameworkFTO geneMass indexGenetic markersEstimationStandard alternativeChatterjee
2016
A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer
Lee A, Bomkamp A, Bandera E, Jensen A, Ramus S, Goodman M, Rossing M, Modugno F, Moysich K, Chang‐Claude J, Rudolph A, Gentry‐Maharaj A, Terry K, Gayther S, Cramer D, Doherty J, Schildkraut J, Kjaer S, Ness R, Menon U, Berchuck A, Mukherjee B, Roman L, Pharoah P, Chenevix‐Trench G, Olson S, Hogdall E, Wu A, Pike M, Stram D, Pearce C, Consortium F. A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer. International Journal Of Cancer 2016, 139: 2646-2654. PMID: 27420401, PMCID: PMC5500237, DOI: 10.1002/ijc.30274.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAllelesAlternative SplicingCase-Control StudiesDisease SusceptibilityEstrogen Replacement TherapyFemaleGene-Environment InteractionGenome-Wide Association StudyGenotypeHumansMenopauseMiddle AgedOdds RatioOvarian NeoplasmsPolymorphism, Single NucleotidePopulation SurveillanceRiskTelomeraseConceptsOvarian Cancer Association ConsortiumEstrogen-alone therapyOvarian cancer riskEndometrioid ovarian cancerOvarian cancerET usersET useT alleleAssociated with ovarian cancer riskCancer riskLong-term ET usersOvarian cancer susceptibility lociRisk of ovarian cancerSusceptibility variantsMenopausal estrogen therapyCancer susceptibility lociSerous ovarian cancerSplice variantsNon-usersCase-control studyConditional logistic regressionGenome-wide association studiesIncreased risk of diseaseEndometrioid histotypeEstrogen therapy
2015
Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth
Chen Y, Ferguson K, Meeker J, McElrath T, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015, 14: 9. PMID: 25619201, PMCID: PMC4417225, DOI: 10.1186/1476-069x-14-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersBostonCase-Control StudiesCross-Sectional StudiesData Interpretation, StatisticalEnvironmental ExposureFemaleHazardous SubstancesHumansInfant, NewbornMaternal ExposureMiddle AgedModels, StatisticalPhthalic AcidsPregnancyPremature BirthSocioeconomic FactorsYoung AdultConceptsPreterm birthEnvironmental chemical exposuresMeasures of urinary phthalate metabolitesNested case-control studyCross-sectional analysisAverage exposureMeasures of exposureCase-control studyUrinary phthalate metabolitesModel repeated measuresEpidemiological research projectsLongitudinal exposureRepeated measuresPremature birthPretermEnvironmental exposure biomarkersExposure measurementsUrinary metabolitesMaternal factorsPhthalate metabolitesPregnancyStudy of phthalatesLongitudinal predictorsChemical exposureBirth
2012
Principal interactions analysis for repeated measures data: application to gene–gene and gene–environment interactions
Mukherjee B, Ko Y, VanderWeele T, Roy A, Park S, Chen J. Principal interactions analysis for repeated measures data: application to gene–gene and gene–environment interactions. Statistics In Medicine 2012, 31: 2531-2551. PMID: 22415818, PMCID: PMC4046647, DOI: 10.1002/sim.5315.Peer-Reviewed Original ResearchConceptsGene-environment interactionsGene-geneLongitudinal cohort studyNormative Aging StudyHealth outcomesMain effect termsMeasured outcomesAging StudyOccupational historyEpistasis modelsEnvironmental exposuresMain effectLongitudinal natureLongitudinal dataResampling-based methodsCell meansClassification arrayQuantitative traitsInteraction analysisRobust classLeading eigenvaluesSimulation studyTime-varying effectsSubject-specificOutcomes
2011
Lead exposure and visual-motor abilities in children from Chennai, India
Palaniappan K, Roy A, Balakrishnan K, Gopalakrishnan L, Mukherjee B, Hu H, Bellinger D. Lead exposure and visual-motor abilities in children from Chennai, India. NeuroToxicology 2011, 32: 465-470. PMID: 21510976, PMCID: PMC3115626, DOI: 10.1016/j.neuro.2011.03.011.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBiomarkersChildChild BehaviorChild DevelopmentChild, PreschoolCross-Sectional StudiesDeveloping CountriesEnvironmental ExposureEnvironmental PollutantsFemaleHumansIndiaLeadLead Poisoning, Nervous System, ChildhoodLinear ModelsMaleNeuropsychological TestsPsychomotor PerformanceRisk AssessmentRisk FactorsSocioeconomic FactorsConceptsHigher blood lead levelsBlood lead levelsEducation levelMotor Ability TestUrban Indian childrenVisual-motor abilitiesCross-sectional studyMother's education levelFather's education levelAverage monthly incomeIndian childrenVisuo-motor developmentLead levelsMotor composite scoresMean blood lead levelLead exposureVisual-motorMonthly incomeDose-effect relationshipVisual-motor integrationComposite scoreSchool childrenHigh Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation
Mukherjee B, Rennert G, Ahn J, Dishon S, Lejbkowicz F, Rennert H, Shiovitz S, Moreno V, Gruber S. High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation. Gastroenterology 2011, 140: 1919-1926. PMID: 21419771, PMCID: PMC4835182, DOI: 10.1053/j.gastro.2011.02.071.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overCase-Control StudiesColorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsFemaleFounder EffectGene FrequencyGenetic Predisposition to DiseaseGenetic TestingHeredityHumansIsraelJewsLikelihood FunctionsMaleMass ScreeningMiddle AgedMutationMutS Homolog 2 ProteinPedigreePenetrancePhenotypeProportional Hazards ModelsRegistriesRisk AssessmentRisk FactorsSex FactorsYoung AdultConceptsRisk of colorectal cancerHazard ratioColorectal cancerCumulative riskPopulation-basedLifetime risk of colorectal cancerCumulative risk of colorectal cancerEstimates of colorectal cancerAge-specific cumulative riskHigh risk of colorectalCases of colorectal cancerModified segregation analysisRisk of colorectalClinical genetics servicesClinic-based sampleEndometrial cancerRisk of ECCase-control studyGenetic servicesLynch syndromeCancer screeningEC riskLifetime riskAshkenazi familiesEstimated penetrance
2010
MLH1 Founder Mutations with Moderate Penetrance in Spanish Lynch Syndrome Families
Borràs E, Pineda M, Blanco I, Jewett E, Wang F, Teulé À, Caldés T, Urioste M, Martínez-Bouzas C, Brunet J, Balmaña J, Torres A, Ramón y Cajal T, Sanz J, Pérez-Cabornero L, Castellví-Bel S, Alonso Á, Lanas Á, González S, Moreno V, Gruber S, Rosenberg N, Mukherjee B, Lázaro C, Capellá G. MLH1 Founder Mutations with Moderate Penetrance in Spanish Lynch Syndrome Families. Cancer Research 2010, 70: 7379-7391. PMID: 20858721, DOI: 10.1158/0008-5472.can-10-0570.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAge FactorsAgedBase SequenceColorectal Neoplasms, Hereditary NonpolyposisFamily HealthFemaleGenetic Predisposition to DiseaseGerm-Line MutationHaplotypesHCT116 CellsHumansMaleMiddle AgedMolecular Sequence DataMutL Protein Homolog 1Nuclear ProteinsPenetranceSpainYoung AdultConceptsLynch syndrome familiesMLH1 c.Molecular diagnosis of Lynch syndromeSyndrome familiesDiagnosis of Lynch syndromeFounder originModerate penetranceModified segregation analysisDNA repair gene MLH1Lynch syndromeMLH1 mutationsGenes MLH1Founder effectMRNA processingLoss of expressionFounder mutationEstimated penetranceFamily historySegregation analysisHaplotype analysisIdentified mutationsCarrier familyPathogenic mutationsGenetic counselingMLH1 protein