Featured Publications
Exploiting Gene-Environment Independence for Analysis of Case–Control Studies: An Empirical Bayes-Type Shrinkage Estimator to Trade-Off Between Bias and Efficiency
Mukherjee B, Chatterjee N. Exploiting Gene-Environment Independence for Analysis of Case–Control Studies: An Empirical Bayes-Type Shrinkage Estimator to Trade-Off Between Bias and Efficiency. Biometrics 2007, 64: 685-694. PMID: 18162111, DOI: 10.1111/j.1541-0420.2007.00953.x.Peer-Reviewed Original ResearchConceptsGene-environment independenceShrinkage estimatorsLog odds ratio parametersCase-control dataGene-environment independence assumptionOdds ratio parametersCase-control estimatorsData-adaptive fashionData exampleProspective logistic regression analysisBinary exposureGene-environment associationsIndependence assumptionLogistic regression analysisCase-onlyMaximum likelihood frameworkEstimationSample sizeBinary genesRegression analysisChatterjeeExamplesWeighted averageAssumptions
2008
Adenoma-infiltrating Lymphocytes (AILs) are a Potential Marker of Hereditary Nonpolyposis Colorectal Cancer
Polydorides A, Mukherjee B, Gruber S, McKenna B, Appelman H, Greenson J. Adenoma-infiltrating Lymphocytes (AILs) are a Potential Marker of Hereditary Nonpolyposis Colorectal Cancer. The American Journal Of Surgical Pathology 2008, 32: 1661-1666. PMID: 18753941, PMCID: PMC3500084, DOI: 10.1097/pas.0b013e31816ffa80.Peer-Reviewed Original ResearchConceptsHereditary nonpolyposis colorectal cancer syndromeColorectal adenomasControl adenomasHereditary nonpolyposis colorectal cancer patientsColorectal cancer syndromePresence of high-grade dysplasiaTumor-infiltrating lymphocytesHigh-grade dysplasiaPresence of necrosisNumbers of mitotic figuresColorectal cancer patientsHost immune responseVillous componentCancer syndromesLack of dirty necrosisSerrated architectureMicrosatellite-unstable colorectal cancersPatient ageGeneral populationPoor differentiationDirty necrosisInexpensive markerHistological featuresColorectal cancerAdenomas