2017
Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis
Smith J, Zhao W, Wang X, Ratliff S, Mukherjee B, Kardia S, Liu Y, Roux A, Needham B. Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics 2017, 12: 662-673. PMID: 28678593, PMCID: PMC5687339, DOI: 10.1080/15592294.2017.1341026.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of AtherosclerosisSocioeconomic disadvantageIndividual-level socioeconomic factorsEtiology of health disparitiesAssociated with poor health outcomesPopulation-based sample of US adultsSocioeconomic factorsNeighborhood conditionsNeighborhood socioeconomic disadvantageSample of US adultsNeighborhood social environmentHigher socioeconomic disadvantagePoor health outcomesIndividual socioeconomic factorsPopulation-based sampleDimensions of neighborhood contextHealth disparitiesInfluence methylation levelsHealth outcomesUS adultsSocial environmentDisadvantaged neighborhoodsNeighborhood characteristics
2015
Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis
Ware E, Mukherjee B, Sun Y, Diez-Roux A, Kardia S, Smith J. Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis. BMC Genomic Data 2015, 16: 118. PMID: 26459564, PMCID: PMC4603946, DOI: 10.1186/s12863-015-0274-0.Peer-Reviewed Original ResearchConceptsMulti-Ethnic StudyGenome-wide association studiesStudies of depressive symptomsMulti-Ethnic Study of AtherosclerosisDepressive symptomsStudy of AtherosclerosisGenome-wide suggestive levelMeasures analysisSingle-nucleotide polymorphismsMultiple ethnicitiesBaseline measurementsMeta-analysisEuropean AmericansLongitudinal measurementsGenome-wide analysisLongitudinal frameworkSuggestive levelAssociation studiesMethodsThis studyEthnicityGenetic predictorsP-valueMood disordersHealthNovel variants