2023
Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation
Kang H, Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Park S. Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation. Environmental Health Perspectives 2023, 131: 087004. PMID: 37552133, PMCID: PMC10408595, DOI: 10.1289/ehp12351.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthOdds ratioWomen's HealthMidlife womenConfidence intervalsFavorable blood lipid profileEstimate odds ratiosAdverse effects of PFASSerum PFAS concentrationsLatent class growth modelingLongitudinal trajectoriesAssociated with totalMenopausal transitionAssociated with trajectoriesLow-density lipoprotein (LDL) cholesterolHigh-density lipoprotein (HDL) cholesterolLipid trajectoriesAverage follow-upBlood total cholesterolBlood lipid profileTriglycerides trajectoriesEpidemiological studiesPositive associationBlood lipidsLDL cholesterolPhthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusEnvironmental ExposureEnvironmental PollutantsFemaleHumansPhthalic AcidsWomen's HealthConceptsStudy of Women's HealthIncidence of diabetesWomen's HealthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidence
2022
Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 317: 120740. PMID: 36436662, PMCID: PMC9897061, DOI: 10.1016/j.envpol.2022.120740.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsExposure to heavy metalsHeavy metalsMetal concentrationsStudy of Women's HealthAssociation of heavy metalsEnvironmental heavy metal exposureHeavy metal exposureSex hormone-binding globulinFollicle-stimulating hormoneWomen's HealthBayesian kernel machine regressionAssociated with E<sub>2</sub>, TMidlife womenKernel machine regressionMetal exposureSerum hormone levelsMetal mixturesHealth-related factorsNation Multi-Pollutant StudyCalculate percent changesCadmiumHormone levelsProspective cohort studyLinear mixed effects modelsPhthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study. Environmental Research 2022, 216: 114685. PMID: 36341787, PMCID: PMC9870605, DOI: 10.1016/j.envres.2022.114685.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueEnvironmental ExposureEnvironmental PollutantsFemaleHumansObesityPhthalic AcidsThinnessWomen's HealthConceptsDual-energy X-ray absorptiometryBody fat gainStudy of Women's HealthBaseline obesity statusFat massFat gainObesity statusPhthalate metabolitesMidlife womenPhthalate exposureWomen's HealthX-ray absorptiometryEtiology of obesityMono-carboxy-isononyl phthalateAttenuation of estimatesBody fat percentageBody weightMono-isobutyl phthalateMono(3-carboxypropyl) phthalateNormal/underweight womenAssociated with faster increasesMenopause-related factorsStudy obesityStratified analysisFM changesPer- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation
Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Harlow S, Park S. Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation. Hypertension 2022, 79: 1876-1886. PMID: 35695012, PMCID: PMC9308661, DOI: 10.1161/hypertensionaha.121.18809.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEnvironmental PollutantsFemaleFluorocarbonsHumansHypertensionWomen's HealthConceptsHazard ratioIncident hypertensionLowest tertileHighest tertileStudy of Women's HealthFree of hypertensionCalculate hazard ratiosAnnual follow-up visitsCardiovascular disease riskCox proportional hazards modelsQuantile g-computationWomen's cardiovascular disease riskWomen's HealthNo significant associationProportional hazards modelMidlife womenFollow-up visitG-computationDisease riskBlood pressure controlSerum concentrationsSignificant associationPositive associationHazards modelTertilePer- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Ding N, Karvonen-Gutierrez C, Calafat A, Herman W, Mukherjee B, Harlow S. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022, 65: 1157-1168. PMID: 35399113, PMCID: PMC9177697, DOI: 10.1007/s00125-022-05695-5.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusEnvironmental PollutantsFemaleFluorocarbonsGlucoseHumansProspective StudiesWomen's HealthConceptsStudy of Women's HealthIncident diabetesWomen's HealthPolyfluoroalkyl substancesDiabetes riskMidlife womenSelf-reported diabetesTotal energy intakeProspective cohort studyIncreased diabetes riskCox proportional hazards modelsPhysical activityGlucose-lowering medicationsProportional hazards modelResultsAfter adjustmentNation Multi-Pollutant StudyBottom tertileSmoking statusHighest tertileAlcohol consumptionDiabetes-free womenFollow-up visitG-computationQuantile-based g-computationCohort studyRace-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 303: 119164. PMID: 35306088, PMCID: PMC9883839, DOI: 10.1016/j.envpol.2022.119164.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAdiponectinBayes TheoremCross-Sectional StudiesFemaleHumansLeptinMiddle AgedParabensPhenolsWomen's HealthConceptsStudy of Women's HealthBayesian kernel machine regressionWomen's HealthLeptin levelsBlack womenAssociated with lower leptinAssociated with favorable profilesAsian womenSoluble leptin receptorRacial differencesRace-specific associationsUrinary phenolCross-sectional associationsNo significant associationObesity-related metabolic diseasesLog-transformed levelsSOB-RKernel machine regressionSerum adipokinesMetabolic disease burdenEffect modificationNation Multi-Pollutant StudyLow leptinLeptin receptorLinear regression models
2021
Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation. Environment International 2021, 157: 106781. PMID: 34311223, PMCID: PMC8490279, DOI: 10.1016/j.envint.2021.106781.Peer-Reviewed Original ResearchConceptsMetal mixturesMetal concentrationsTiming of natural menopauseCox proportional hazards modelsNatural menopauseStudy of Women's HealthProportional hazards modelHazard ratioEnvironmental risk scoreLowest quartileIndividual metal concentrationsExposure to metalsUrinary metal concentrationsHazards modelMedian follow-upMonths of amenorrheaWomen's HealthAssociated with earlier natural menopauseEarly natural menopauseUrinary metalsNation Multi-Pollutant StudyBleeding episodesHormone therapyPremenopausal womenMedian agePer- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition
Harlow S, Hood M, Ding N, Mukherjee B, Calafat A, Randolph J, Gold E, Park S. Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4427-e4437. PMID: 34181018, PMCID: PMC8677593, DOI: 10.1210/clinem/dgab476.Peer-Reviewed Original ResearchConceptsMidlife womenSex hormone-binding globulinFollicle-stimulating hormoneInverse associationStudy of Women's HealthPositive associationMenopausal transitionBody mass indexReproductive ageWomen's HealthSignificant linear trendNo significant associationNulliparous womenLinear mixed modelsSmoking statusYears of ageMass indexHormone-binding globulinMenopausal statusLongitudinal serum concentrationsSignificant associationSerum PFAS concentrationsMidlifeWomenPolyfluoroalkyl substancesUrinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation. Hypertension 2021, 78: 543-551. PMID: 34148361, PMCID: PMC8266752, DOI: 10.1161/hypertensionaha.121.17295.Peer-Reviewed Original ResearchAssociations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women. International Journal Of Hygiene And Environmental Health 2021, 235: 113777. PMID: 34090141, PMCID: PMC8207532, DOI: 10.1016/j.ijheh.2021.113777.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAlkanesulfonic AcidsBayes TheoremEnvironmental PollutantsFemaleFluorocarbonsHumansWomen's HealthConceptsBayesian kernel machine regressionNormal weightStudy of Women's HealthCirculating levels of leptinHMW adiponectinBayesian kernel machine regression analysisSoluble leptin receptorFree leptin indexSOB-R concentrationsBaseline serum samplesLevels of leptinMultivariate linear regressionPhysical activityAssociated with obesityStatistically significant associationWomen's HealthPolyfluoroalkyl substancesWaist circumferenceKernel machine regressionWomen's backgroundInfluence obesityMidlife womenSmoking statusSOB-RMenopausal status
2020
Urinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN)
Wang X, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Urinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN). Environmental Research 2020, 196: 110426. PMID: 33157106, PMCID: PMC8093324, DOI: 10.1016/j.envres.2020.110426.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthWomen's HealthExposure to cadmiumUrinary metal concentrationsUrinary molybdenumMetal concentrationsMetal exposureSOB-RUrinary metalsNation Multi-Pollutant StudyAssociated with favorable profilesStandard deviation increaseCadmiumLinear regression modelsAdverse adipokine profileMidlife womenLevels of sOB-RHMW adiponectinUrinary cesiumFollow-up visitHuman populationSoluble leptin receptorAdaptive elastic-netSOB-R levelsMetalUrinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN)
Wang X, Mukherjee B, Karvonen-Gutierrez C, Herman W, Batterman S, Harlow S, Park S. Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN). Environment International 2020, 145: 106109. PMID: 32927284, PMCID: PMC7577932, DOI: 10.1016/j.envint.2020.106109.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesFemaleGlucoseHomeostasisHumansInsulin ResistanceMetalsMiddle AgedWomen's HealthConceptsEnvironmental risk scoreStudy of Women's HealthWomen's HealthExposure to metal mixturesElevated diabetes riskAssociated with lower HOMA-IRUrinary metal mixtureLongitudinal changesMetal mixturesHOMA-BYears of follow-upRate of changeHOMA-IRAdaptive elastic-netStandard deviation increaseDiabetes riskLinear mixed effects modelsLower HOMA-IRRandom interceptMixed effects modelsRisk scoreAssociated with higher HOMA-IRMetal mixture effectsEpidemiological studiesDeviation increaseUrinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN)
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN). BMJ Open Diabetes Research & Care 2020, 8: e001233. PMID: 32747380, PMCID: PMC7398092, DOI: 10.1136/bmjdrc-2020-001233.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsMetal concentrationsMetal mixturesUrinary excretion of zincStudy of Women's HealthExposure to metal mixturesExcretion of zincIncident diabetesWomen's HealthAssociated with higher risk of diabetesSelf-reported doctor-diagnosed diabetesMidlife womenAssociated with higher riskUrinary metalsHigh risk of diabetesCox proportional hazards modelsIncreased urinary excretionMultiethnic Cohort StudyFree of diabetesHigher overall exposureIncreased urinary excretion of zincAssociated with elevated riskRisk of diabetesDoctor-diagnosed diabetesHigher urinary concentrationsAssociations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's HealthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
2019
Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation
Ding N, Harlow S, Batterman S, Mukherjee B, Park S. Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation. Environment International 2019, 135: 105381. PMID: 31841808, PMCID: PMC7374929, DOI: 10.1016/j.envint.2019.105381.Peer-Reviewed Original ResearchConceptsMidlife womenWomen's HealthBlack womenStudy of Women's HealthChinese womenLongitudinal trendsTemporal trendsBody mass indexSerum concentrationsLinear mixed modelsParous womenFollow-up visitPFAS homologuesPFNA concentrationsRace/ethnicityMass indexSerum PFAS concentrationsMidlifePatterns of exposurePolyfluoroalkyl substances concentrationsLongitudinal declineWomenAssociated with lower concentrationsHealthMixed models