2024
Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposure
2021
Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition
Harlow S, Hood M, Ding N, Mukherjee B, Calafat A, Randolph J, Gold E, Park S. Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4427-e4437. PMID: 34181018, PMCID: PMC8677593, DOI: 10.1210/clinem/dgab476.Peer-Reviewed Original ResearchConceptsMidlife womenSex hormone-binding globulinFollicle-stimulating hormoneInverse associationStudy of Women's HealthPositive associationMenopausal transitionBody mass indexReproductive ageWomen's HealthSignificant linear trendNo significant associationNulliparous womenLinear mixed modelsSmoking statusYears of ageMass indexHormone-binding globulinMenopausal statusLongitudinal serum concentrationsSignificant associationSerum PFAS concentrationsMidlifeWomenPolyfluoroalkyl substancesPerformance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting
Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting. Environmental Research 2021, 200: 111435. PMID: 34097892, PMCID: PMC8403638, DOI: 10.1016/j.envres.2021.111435.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCohort StudiesFemaleHumansInfant, NewbornMetalsPregnancyPremature BirthPuerto RicoConceptsEnvironmental risk scoreIntraclass correlation coefficientBirth outcomesBody mass indexWeighted quantile sumOdds ratio of preterm birthSecond-hand smoke exposurePre-pregnancy body mass indexOdds of preterm birthAssociated with birth outcomesIncreased odds of preterm birthPractice study designHealth effectsPreterm birthMaternal educationIncreased oddsOdds ratioSmoke exposureStudy designMaternal ageMass indexArea under the curveRisk scoreLogistic regressionConfidence intervalsPerfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018. International Journal Of Obesity 2021, 45: 1937-1948. PMID: 33986457, PMCID: PMC8384652, DOI: 10.1038/s41366-021-00848-9.Peer-Reviewed Original ResearchConceptsWaist circumferenceMidlife womenFat massLowest tertileAssociated with greater body sizeStudy of women's healthResultsAfter multivariable adjustmentAssociated with accelerated increaseTrajectories of weightAssociated with weightSubjects/MethodsThis studyWomen's HealthObesity riskFollow-upDual-energy X-ray absorptiometryLinear mixed modelsHighest tertileX-ray absorptiometryGreater body sizeMultivariable adjustmentBody fatEpidemiological evidenceNo significant resultsBody compositionAverage follow-upPsychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes
Ashrap P, Aker A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021, 149: 106418. PMID: 33548848, PMCID: PMC7897320, DOI: 10.1016/j.envint.2021.106418.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesPsychosocial statusBirth outcomesBody mass indexPsychosocial stressPreterm birthOdds ratioAssociated with adverse birth outcomesPre-pregnancy body mass indexSecond-hand smoke exposurePrenatal psychosocial stressPregnant womenBlood metalsClusters of womenEffects of psychosocial stressPuerto Rico TestsiteIncreased odds ratioSocial supportPerceived stressMaternal educationAdverse associationOverall preterm birthLow birth weightSpontaneous preterm birthCohort study
2020
Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN)
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN). BMJ Open Diabetes Research & Care 2020, 8: e001233. PMID: 32747380, PMCID: PMC7398092, DOI: 10.1136/bmjdrc-2020-001233.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsMetal concentrationsMetal mixturesUrinary excretion of zincStudy of Women's HealthExposure to metal mixturesExcretion of zincIncident diabetesWomen's HealthAssociated with higher risk of diabetesSelf-reported doctor-diagnosed diabetesMidlife womenAssociated with higher riskUrinary metalsHigh risk of diabetesCox proportional hazards modelsIncreased urinary excretionMultiethnic Cohort StudyFree of diabetesHigher overall exposureIncreased urinary excretion of zincAssociated with elevated riskRisk of diabetesDoctor-diagnosed diabetesHigher urinary concentrationsAssociations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's HealthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
2019
Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort
Aker A, McConnell R, Loch-Caruso R, Park S, Mukherjee B, Rosario Z, Vélez-Vega C, Huerta-Montanez G, Alshawabkeh A, Cordero J, Meeker J. Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort. The Science Of The Total Environment 2019, 708: 134719. PMID: 31785910, PMCID: PMC6957748, DOI: 10.1016/j.scitotenv.2019.134719.Peer-Reviewed Original ResearchConceptsLife eventsLinear regression modelsMultiple linear regression modelNegative life eventsPresence of negative life eventsPsychosocial stress measuresAdverse birth outcomesPregnancy cohort studyRegression modelsEffects of psychosocial stressPsychosocial factorsNon-chemical stressorsBirth outcomesEffects of life eventsCohort studyPsychosocial stressPositive LEsPositive life eventsExposure biomarkersSignificant modifiersPrenatal exposureSignificant interactionWomenAssociationRate of eventsUrinary metals and metal mixtures in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Mukherjee B, Batterman S, Harlow S, Park S. Urinary metals and metal mixtures in midlife women: The Study of Women's Health Across the Nation (SWAN). International Journal Of Hygiene And Environmental Health 2019, 222: 778-789. PMID: 31103473, PMCID: PMC6583796, DOI: 10.1016/j.ijheh.2019.05.002.Peer-Reviewed Original ResearchConceptsMultiple metalsMetal mixturesExposure to multiple metalsExposure patternsConcentrations of metalsExposure to metalsConsumption of seafoodHigh-resolution inductively coupled plasma mass spectrometryInductively coupled plasma mass spectrometryMeasured urinary concentrationsGeometric mean concentrationsMetal exposurePlasma mass spectrometrySeafood intakeUrinary metalsMean concentrationsRice intakeSeafoodUrinary concentrationsDetectable concentrationHigher exposuresGeographical characteristicsMercuryLead levelsMetalAssociation Between Life Purpose and Mortality Among US Adults Older Than 50 Years
Alimujiang A, Wiensch A, Boss J, Fleischer N, Mondul A, McLean K, Mukherjee B, Pearce C. Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years. JAMA Network Open 2019, 2: e194270. PMID: 31125099, PMCID: PMC6632139, DOI: 10.1001/jamanetworkopen.2019.4270.Peer-Reviewed Original ResearchConceptsHealth and Retirement StudyCause-specific mortalityAll-causeHealth outcomesUS adultsHealth and Retirement Study participantsCohort study of US adultsCause-specific mortality analysesInterview periodStudy of US adultsInfluence health outcomesAssociated with all-cause mortalityLife purposeCohort study sampleWeighted Cox proportional hazards modelsNational cohort studyPurpose in lifeQuality of lifeAll-cause mortalityCox proportional hazards modelsEnhance overall qualityAssociated with decreased mortalityProportional hazards modelRetirement StudyMortality associationsA repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Calafat A, Cordero J, Meeker J. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019, 18: 28. PMID: 30940137, PMCID: PMC6444601, DOI: 10.1186/s12940-019-0459-5.Peer-Reviewed Original ResearchConceptsUrinary biomarkersAssociated with adverse birth outcomesAdverse birth outcomesPregnant womenBirth outcomesAdverse outcomesSerum hormonesStudy visitsParaben biomarkersThyroid hormonesParaben exposurePercent changeHormoneBiomarker concentrationsMaternal hormonesBiomarkersOutcomesVisitsAssociationExposureGestationRandom interceptPregnancyThyroid
2018
Evaluating the Risk of Noise-Induced Hearing Loss Using Different Noise Measurement Criteria
Roberts B, Seixas N, Mukherjee B, Neitzel R. Evaluating the Risk of Noise-Induced Hearing Loss Using Different Noise Measurement Criteria. Annals Of Work Exposures And Health 2018, 62: 295-306. PMID: 29415217, DOI: 10.1093/annweh/wxy001.Peer-Reviewed Original ResearchConceptsHearing threshold levelsHearing outcomesHearing lossOccupational Safety and Health AdministrationRisk of noise-induced hearing lossHealth AdministrationNoise exposureOccupational Safety and HealthNoise-induced hearing lossInstitute of Occupational Safety and HealthSafety and HealthNational Institute of Occupational Safety and HealthCohort of construction workersMixed modelsDuration of participationAssessment of noise exposureMeasures of exposureHearing levelAkaike’s information criterion differencesConstruction workersAverage noise levelLinear mixed modelsLAVGContinuous averagingOSHAAssociations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study
Aker A, Johns L, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment International 2018, 113: 341-349. PMID: 29366524, PMCID: PMC5866216, DOI: 10.1016/j.envint.2018.01.006.Peer-Reviewed Original ResearchConceptsThyroid hormonesAssociated with altered thyroid hormone levelsFetal health outcomesThyroid hormone levelsIQR increaseMultivariate regression analysisGestational ageMultivariate linear regression modelFetal neurodevelopmentPregnant womenFree thyroxinePotential biological mechanismsTime of exposureUrinary biomarkersCohort studyHormone levelsParaben biomarkersTotal triiodothyronineCase-control samplePregnancyBlood samplesTotal thyroxineHormone concentrationsHealth outcomesHormoneSubset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes
Yu Y, Xia L, Lee S, Zhou X, Stringham H, Boehnke M, Mukherjee B. Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes. Human Heredity 2018, 83: 283-314. PMID: 31132756, PMCID: PMC7034441, DOI: 10.1159/000496867.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCholesterolCohort StudiesComputer SimulationC-Reactive ProteinFinlandGene FrequencyGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLipoproteins, LDLMeta-Analysis as TopicModels, GeneticPhenotypePolymorphism, Single NucleotideConceptsPresence of G-E interactionsGenetic associationHeterogeneity of genetic effectsDiscovery of genetic associationsGene-environment (G-EMarginal genetic effectsG-E interactionsGenome-wide association studiesGene-environment interactionsGenetic effectsData examplesSimulation studySingle nucleotide polymorphismsGene-environmentAssociation studiesAssociation analysisScreening toolMarginal associationNucleotide polymorphismsPresence of heterogeneityAssociationEnvironmental factorsIncreased powerMultiple studiesG-E
2016
Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies
Ferguson K, Meeker J, McElrath T, Mukherjee B, Cantonwine D. Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. American Journal Of Obstetrics And Gynecology 2016, 216: 527.e1-527.e9. PMID: 28043842, PMCID: PMC5420472, DOI: 10.1016/j.ajog.2016.12.174.Peer-Reviewed Original ResearchConceptsTumor necrosis factor-aNormotensive pregnanciesC-reactive proteinMeasures of inflammationHazard ratioOxidative stress biomarkersInterleukin-1bTime pointsInflammation biomarkersStudy visitsTime of preeclampsia diagnosisPrediction of preeclampsiaOxidative stressHigher body mass indexOxidative stress biomarker 8-isoprostaneStress biomarkersCox proportional hazards modelsCompared to other time pointsBody mass indexProspective birth cohortCalculate hazard ratiosSmall study populationPanel of inflammationFactor AProportional hazards modelOn-time Measles and Pneumococcal Vaccination of Shanghai Children
Wagner A, Sun X, Huang Z, Ren J, Mukherjee B, Wells E, Boulton M. On-time Measles and Pneumococcal Vaccination of Shanghai Children. The Pediatric Infectious Disease Journal 2016, 35: e311-e317. PMID: 27294307, DOI: 10.1097/inf.0000000000001267.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccinePneumococcal conjugate vaccine administrationMeasles-containing vaccineMonths of ageShanghai Immunization Program Information SystemProportion of infant deathsShanghai childrenComparator vaccineDose 2Logistic regression modelsConjugate vaccineDose 1Pneumococcal vaccineImmunization scheduleVaccination outcomesInfant deathsPediatric immunization scheduleVaccineMonthsDisease control effortsLate vaccinationOddsAdministrationChina censusVaccination levels
2014
The Role of Environmental Heterogeneity in Meta‐Analysis of Gene–Environment Interactions With Quantitative Traits
Li S, Mukherjee B, Taylor J, Rice K, Wen X, Rice J, Stringham H, Boehnke M. The Role of Environmental Heterogeneity in Meta‐Analysis of Gene–Environment Interactions With Quantitative Traits. Genetic Epidemiology 2014, 38: 416-429. PMID: 24801060, PMCID: PMC4108593, DOI: 10.1002/gepi.21810.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiasBody Mass IndexCase-Control StudiesCholesterol, HDLCohort StudiesDiabetes Mellitus, Type 2Gene FrequencyGene-Environment InteractionGenetic Predisposition to DiseaseHumansMeta-Analysis as TopicModels, GeneticPhenotypePolymorphism, Single NucleotideProteinsQuantitative Trait, HeritableConceptsIndividual level dataMeta-analysisInverse-variance weighted meta-analysisEnvironmental heterogeneityGene-environment interaction studiesInverse-variance weighted estimatorMeta-analysis of interactionsStudy of type 2 diabetesGene-environment interactionsBody mass indexMeta-regression approachSingle nucleotide polymorphismsAdaptive weighted estimatorFTO geneType 2 diabetesMass indexMeta-regressionQuantitative traitsSummary statisticsCholesterol dataNucleotide polymorphismsLevel dataUnivariate summary statisticsData harmonizationEnvironmental covariatesPersonal Black Carbon Exposure Influences Ambulatory Blood Pressure
Zhao X, Sun Z, Ruan Y, Yan J, Mukherjee B, Yang F, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Brook J, Sun Q, Brook R, Rajagopalan S, Fan Z. Personal Black Carbon Exposure Influences Ambulatory Blood Pressure. Hypertension 2014, 63: 871-877. PMID: 24420543, PMCID: PMC4445364, DOI: 10.1161/hypertensionaha.113.02588.Peer-Reviewed Original ResearchConceptsPersonal black carbonAir pollutionBlack carbonBeijing Municipal Environmental Monitoring CenterFine particulate matter concentrationsCombustion-related air pollutionFine particulate matterAmbulatory blood pressureEnvironmental Monitoring CenterParticulate matter concentrationsBlood pressureHigh air pollutionReduce air pollutionMm HgLow frequency to high frequency ratioPublic health effectsParticulate matterTwenty-four-hour ambulatory blood pressureExposure to high levelsMatter concentrationSystolic blood pressureDiastolic blood pressurePollutionBlood pressure effectsGeneralized linear model
2012
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
Lewis T, Robins T, Mentz G, Zhang X, Mukherjee B, Lin X, Keeler G, Dvonch J, Yip F, O'Neill M, Parker E, Israel B, Max P, Reyes A, Committee C. Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area. The Science Of The Total Environment 2012, 448: 48-55. PMID: 23273373, PMCID: PMC4327853, DOI: 10.1016/j.scitotenv.2012.11.070.Peer-Reviewed Original ResearchConceptsParticulate matterAir pollutionAssociated with negative health impactsAmbient pollutant concentrationsAir quality standardsAmbient air pollutionAmbient particulate matterEffective risk reduction interventionsOdds of respiratory symptomsAsthmatic childrenFactors associated with heterogeneityAssociated with increased oddsObserved health effectsRespiratory symptomsRisk reduction interventionsPopulation of asthmatic childrenRespiratory symptom diariesOutdoor PMDaily concentrationsPollutant concentrationsMonitoring sitesGeneralized estimating equationsPollution modelLogistic regression modelsAerodynamic diameter
2010
Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study
Park S, Elmarsafawy S, Mukherjee B, Spiro A, Vokonas P, Nie H, Weisskopf M, Schwartz J, Hu H. Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study. Hearing Research 2010, 269: 48-55. PMID: 20638461, PMCID: PMC2934752, DOI: 10.1016/j.heares.2010.07.004.Peer-Reviewed Original ResearchConceptsAge-related hearing lossPure-tone averagePatella lead levelsCumulative lead exposureHearing lossHearing thresholdsNormative Aging StudyAssociated with poorer hearing thresholdsOdds of hearing lossAir conduction hearing thresholdsAssociated with hearing lossConduction hearing thresholdsPoorer hearing thresholdsAging StudyDevelopment of age-related hearing lossReduction of lead exposureVA Normative Aging StudyCross-sectional analysisLead exposureOccupational noiseHearing abilityK X-ray fluorescencePotential confoundersEpidemiological researchLead levels