2023
Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusEnvironmental ExposureEnvironmental PollutantsFemaleHumansPhthalic AcidsWomen's HealthConceptsStudy of Women's HealthIncidence of diabetesWomen's HealthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidence
2022
Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study. Environmental Research 2022, 216: 114685. PMID: 36341787, PMCID: PMC9870605, DOI: 10.1016/j.envres.2022.114685.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueEnvironmental ExposureEnvironmental PollutantsFemaleHumansObesityPhthalic AcidsThinnessWomen's HealthConceptsDual-energy X-ray absorptiometryBody fat gainStudy of Women's HealthBaseline obesity statusFat massFat gainObesity statusPhthalate metabolitesMidlife womenPhthalate exposureWomen's HealthX-ray absorptiometryEtiology of obesityMono-carboxy-isononyl phthalateAttenuation of estimatesBody fat percentageBody weightMono-isobutyl phthalateMono(3-carboxypropyl) phthalateNormal/underweight womenAssociated with faster increasesMenopause-related factorsStudy obesityStratified analysisFM changesBiomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortMaternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomesMediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 374-383. PMID: 34987188, PMCID: PMC9124667, DOI: 10.1038/s41370-021-00408-3.Peer-Reviewed Original ResearchMeSH KeywordsEnvironmental PollutantsFemaleGestational AgeHormonesHumansInfant, NewbornMalePhthalic AcidsPregnancyPremature BirthConceptsSpontaneous preterm birthPreterm birthCorticotropin-releasing hormoneFetal sexMale fetusesEarly deliveryHormone concentrationsAssociated with earlier deliveryPhthalate exposurePhthalate mixtureReduced gestational ageTime of deliveryEnvironmental risk scoreGestational ageFemale fetusesUrinary phthalatesSex-specific analysesEndocrine-disrupting capabilitiesReleasing hormoneSerum hormonesFetusesRisk scoreSusceptible to endocrine disruptionBirth cohortHormone
2021
Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBiomarkersFemaleHumansOxidative StressPhthalic AcidsPregnancyPregnant WomenPuerto RicoConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposureCross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches. Environmental Health Perspectives 2021, 129: 037007. PMID: 33761273, PMCID: PMC7990518, DOI: 10.1289/ehp7396.Peer-Reviewed Original ResearchConceptsExposure analytesToxicity classesMixtures of toxicantsSingle-pollutant modelsPolycyclic aromatic hydrocarbonsHierarchical Bayesian kernel machine regressionBayesian kernel machine regressionKernel machine regressionPrenatal toxicant exposureAdaptive elastic net regressionClasses of toxicantsSingle-pollutantTrace metalsAromatic hydrocarbonsToxic mixturePair-wise associationsAdaptive elastic netToxicant exposurePhthalateMachine regressionEndogenous biomarkersBiomarkers indicativeMultiple linear regressionMetalToxicity
2020
Application of an analytical framework for multivariate mediation analysis of environmental data
Aung M, Song Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Meeker J, Mukherjee B. Application of an analytical framework for multivariate mediation analysis of environmental data. Nature Communications 2020, 11: 5624. PMID: 33159049, PMCID: PMC7648785, DOI: 10.1038/s41467-020-19335-2.Peer-Reviewed Original Research
2019
Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates
Ferguson K, Lan Z, Yu Y, Mukherjee B, McElrath T, Meeker J. Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates. Environment International 2019, 131: 104903. PMID: 31288179, PMCID: PMC6728185, DOI: 10.1016/j.envint.2019.104903.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesOxidative stress biomarkersNon-null associationsPhthalate metabolitesBiomarkers of oxidative stressInterquartile rangeBenzophenone-3Associated with increasesOutcome biomarkersIncreased maternal oxidative stressStress biomarkersExposure to environmental phenolsOxidative stressReduced fetal growthUrinary oxidative stress biomarkersMaternal oxidative stressEffect estimatesAdaptive elastic net modelStudy populationPreterm birthFetal growthConcentration of phenolUrinary phenolPregnancyUrinary concentrations
2018
Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores
Boss J, Zhai J, Aung M, Ferguson K, Johns L, McElrath T, Meeker J, Mukherjee B. Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores. Environmental Health 2018, 17: 56. PMID: 29925380, PMCID: PMC6011420, DOI: 10.1186/s12940-018-0400-3.Peer-Reviewed Original ResearchConceptsMono-2-ethyl-5-carboxypentyl phthalateEnvironmental risk scoreGestational ageHazard ratioPreterm birthRisk scoreInterquartile rangeIncreased odds of preterm birthCases of preterm birthOdds of preterm birthUrinary phthalate metabolite concentrationsPhthalate metabolite concentrationsUrinary phthalate metabolitesPhthalate metabolite measurementsCox proportional hazards modelsInterquartile range changeTime to deliveryProportional hazards modelLongitudinal birth cohortSingle-pollutant analysesSignificant public health concernUrinary metabolite concentrationsBackgroundPreterm birthPregnant womenExposure to phthalates
2017
Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis
Johns L, Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2017, 125: 087026. PMID: 28934718, PMCID: PMC5783673, DOI: 10.1289/ehp1178.Peer-Reviewed Original ResearchConceptsCohort of pregnant womenMono-3-carboxypropyl phthalateVitamin D levelsPregnant womenD levelsNested case-control study of preterm birthMeasures of urinary phthalate metabolitesProspective cohort of pregnant womenOdds of vitamin D deficiencyCase-control study of preterm birthDi(2-ethylhexyl) phthalate metabolitesInverse associationStudy of preterm birthInterquartile rangePlasma vitamin D levelsCirculating total 25(OH)DNested case-control studyMetabolites of di(2-ethylhexyl) phthalateVitamin D deficiencyDi(2-ethylhexyl) phthalatePhthalate metabolite concentrationsUrinary phthalate metabolitesUrinary bisphenol AProspective birth cohortPreterm birth
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersEnvironmental PollutantsFemaleHumansMaternal ExposureOxidative StressPhthalic AcidsPregnancyPremature BirthConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociationUrinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth
Ferguson K, Meeker J, Cantonwine D, Chen Y, Mukherjee B, McElrath T. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016, 94: 531-537. PMID: 27320326, PMCID: PMC4980186, DOI: 10.1016/j.envint.2016.06.013.Peer-Reviewed Original ResearchConceptsActual fetal weightUrinary phthalate metabolitesPhthalate metabolitesFetal weightFetal growthDi-2-ethylhexyl phthalate metabolitesNon-anomalous singleton pregnanciesAssociated with decreased fetal growthConcentrations of phthalate metabolitesTime pointsExposure to di-2-ethylhexyl phthalateSingleton pregnanciesLongitudinal birth cohortFetal sexDi-2-ethylhexyl phthalateInterquartile range increaseCross-sectional associationsUltrasound scanPregnancyInverse associationMaternal exposureDelivery indexUrine samplesStandard deviation decreaseBirth cohortAssociations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy
Johns L, Ferguson K, McElrath T, Mukherjee B, Meeker J. Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy. Environmental Health Perspectives 2016, 124: 1808-1815. PMID: 27152641, PMCID: PMC5089879, DOI: 10.1289/ehp170.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesFemaleFetal DevelopmentHomeostasisHumansLinear ModelsPhthalic AcidsPregnancyThyroid HormonesConceptsUrinary phthalate metabolitesMaternal urinary phthalate metabolitesThyroid hormone parametersThyroid hormone levelsPregnant womenPhthalate metabolitesStudy visitsHormonal parametersNested case-control study of preterm birthMeasures of urinary phthalate metabolitesHormone levelsCase-control study of preterm birthStudy of preterm birthThyroid hormonesEnvironmental phthalate exposureNested case-control studyNormal thyroid functionLevels of thyroid hormonesThyroid function markersTime pointsCirculating levels of thyroid hormonesTotal thyroid hormonesPreterm birthFetal growthPlasma thyroid hormone levels
2015
Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy
Ferguson K, McElrath T, Mukherjee B, Loch-Caruso R, Meeker J. Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy. PLOS ONE 2015, 10: e0135601. PMID: 26317519, PMCID: PMC4552851, DOI: 10.1371/journal.pone.0135601.Peer-Reviewed Original ResearchConceptsC-reactive proteinPregnant womenPhthalate exposureInvestigate inflammationInflammation biomarkersAnalysis of pregnant womenAssociated with adverse reproductive outcomesBiomarkers of phthalate exposureUrinary phthalate metabolitesAssociated with IL-6Plasma inflammation biomarkersMono-benzyl phthalateAdverse reproductive outcomesStatistically significant associationUrinary metabolite concentrationsMaternal biomarkersPeripheral inflammationPhthalate effectsPhthalate metabolitesIL-6Reproductive outcomesInflammationMono-benzylSignificant associationTarget tissuesPhthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy
Ferguson K, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy. Placenta 2015, 36: 699-703. PMID: 25913709, PMCID: PMC4441857, DOI: 10.1016/j.placenta.2015.04.002.Peer-Reviewed Original ResearchConceptsSFlt-1 to PlGF ratioSFlt-1Biomarkers of angiogenesisPhthalate metabolitesPlGF ratioPlacental developmentSoluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Tyrosine kinase-1Placental growth factorUrinary DEHP metabolitesProspective birth cohortAdverse birth outcomesCase-control populationDelivered pretermGestational ageAngiogenic biomarkersExposure to phthalatesUrinary biomarkersDEHP metabolitesBirth outcomesPlasma biomarkersPregnancyPlGFAssociated with decreasesStatistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth
Chen Y, Ferguson K, Meeker J, McElrath T, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015, 14: 9. PMID: 25619201, PMCID: PMC4417225, DOI: 10.1186/1476-069x-14-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersBostonCase-Control StudiesCross-Sectional StudiesData Interpretation, StatisticalEnvironmental ExposureFemaleHazardous SubstancesHumansInfant, NewbornMaternal ExposureMiddle AgedModels, StatisticalPhthalic AcidsPregnancyPremature BirthSocioeconomic FactorsYoung AdultConceptsPreterm birthEnvironmental chemical exposuresMeasures of urinary phthalate metabolitesNested case-control studyCross-sectional analysisAverage exposureMeasures of exposureCase-control studyUrinary phthalate metabolitesModel repeated measuresEpidemiological research projectsLongitudinal exposureRepeated measuresPremature birthPretermEnvironmental exposure biomarkersExposure measurementsUrinary metabolitesMaternal factorsPhthalate metabolitesPregnancyStudy of phthalatesLongitudinal predictorsChemical exposureBirth
2014
Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2014, 123: 210-216. PMID: 25402001, PMCID: PMC4348741, DOI: 10.1289/ehp.1307996.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesMono-n-butyl phthalateBiomarkers of oxidative stressBirth outcomesNested case-control study of preterm birthCase-control study of preterm birthPhthalate exposureStudy of preterm birthStudy of birth outcomesOxidative stressPopulation of pregnant womenNested case-control studyStudy population of pregnant womenAdverse birth outcomesUrine samplesMarkers of oxidative stressRepeated measures analysisHealth end pointsAssociated with significantly higher concentrationsDi(2-ethylhexyl) phthalatePreterm birthPregnant womenMono-n-butylLinear mixed modelsVariability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70: 118-124. PMID: 24934852, PMCID: PMC4104181, DOI: 10.1016/j.envint.2014.05.016.Peer-Reviewed Original ResearchConceptsAdjusted odds ratiosUrinary phthalate metabolite levelsPreterm birthPhthalate metabolite levelsOdds ratioOdds of preterm birthAssociated with increased odds of preterm birthIncreased risk of delivering pretermCases of preterm birthWeeks of completed gestationRisk of delivering pretermAssociated with increased oddsMetabolite levelsPresentation of preeclampsiaSignificant public health problemSpontaneous preterm birthIntrauterine growth restrictionLongitudinal birth cohortPhthalate metabolite concentrationsPublic health problemBirth outcomesBirth cohortGrowth restrictionThird trimesterPregnant womenUrinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico
Ferguson K, Cantonwine D, Rivera-González L, Loch-Caruso R, Mukherjee B, Del Toro L, Jiménez-Vélez B, Calafat A, Ye X, Alshawabkeh A, Cordero J, Meeker J. Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico. Environmental Science And Technology 2014, 48: 7018-7025. PMID: 24845688, PMCID: PMC4066910, DOI: 10.1021/es502076j.Peer-Reviewed Original ResearchConceptsMono-n-butyl phthalateBiomarkers of inflammationIL-10Prospective cohort study of pregnant womenDi-2-ethylhexyl phthalate metabolitesCohort study of pregnant womenIL-6Study of pregnant womenAssociated with increased IL-6Oxidative stressUrinary phthalate metabolitesC-reactive proteinProspective cohort studyAdverse birth outcomesMetabolites of di-2-ethylhexyl phthalateOxidative stress markersPreterm birthMetabolite associationsPregnant womenMono-n-butylDi-2-ethylhexyl phthalateOxidative stress biomarkersBirth outcomesTNF-aInflammation biomarkers