2017
Meta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies
Estes J, Rice J, Li S, Stringham H, Boehnke M, Mukherjee B. Meta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies. Statistics In Medicine 2017, 36: 3895-3909. PMID: 28744888, PMCID: PMC5624850, DOI: 10.1002/sim.7398.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-Ketoglutarate-Dependent Dioxygenase FTOBayes TheoremBiasBiometryBody Mass IndexCase-Control StudiesComputer SimulationDiabetes Mellitus, Type 2Gene-Environment InteractionHumansLogistic ModelsMeta-Analysis as TopicModels, GeneticModels, StatisticalPolymorphism, Single NucleotideRetrospective StudiesConceptsGene-environment independenceGene-environmentEmpirical Bayes estimatorsGene-environment interactionsCase-control studyMeta-analysis settingBayes estimatorsRetrospective likelihood frameworkShrinkage estimatorsMeta-analysisTesting gene-environment interactionsCombination of estimatesFactors body mass indexSimulation studyBody mass indexUnconstrained modelLikelihood frameworkInverse varianceMeta-analysis frameworkFTO geneMass indexGenetic markersEstimationStandard alternativeChatterjee
2011
Testing Gene-Environment Interaction in Large-Scale Case-Control Association Studies: Possible Choices and Comparisons
Mukherjee B, Ahn J, Gruber S, Chatterjee N. Testing Gene-Environment Interaction in Large-Scale Case-Control Association Studies: Possible Choices and Comparisons. American Journal Of Epidemiology 2011, 175: 177-190. PMID: 22199027, PMCID: PMC3286201, DOI: 10.1093/aje/kwr367.Peer-Reviewed Original ResearchConceptsGene-environment independenceGene-environment interactionsCase-only methodTesting gene-environment interactionsCase-control testsExposure under studyCase-control association studyUnderlying populationCase-control methodCase-control analysisFraction of markersType I error propertiesGenome-wide scanClass of proceduresAssociation studiesData-adaptive wayComparative simulation studyLarge-scale studiesEmpirical-BayesIndependence assumptionFalse positivesPopulationReplication strategyHybrid methodIndependence