Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
Lewis T, Metitiri E, Mentz G, Ren X, Carpenter A, Goldsmith A, Wicklund K, Eder B, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M. Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children. Respiratory Research 2018, 19: 228. PMID: 30463560, PMCID: PMC6249926, DOI: 10.1186/s12931-018-0922-9.Peer-Reviewed Original ResearchConceptsViral infectionLung functionAbsence of viral infectionIL-13IL-4Viral-induced asthma exacerbationsRespiratory illnessRespiratory viral infectionsAssociated with increased cytokinesPro-inflammatory cytokinesLung function declineSelf-reported respiratory illnessInfluence of viral infectionAirway cytokinesMDA5 mRNACXCL10 mRNACytokine levelsAirway responsivenessNasal lavageAirflow obstructionAssociated with FVCAsthma exacerbationsAssociated with decreased lung functionInflammatory responseNasal samplesImpact of community respiratory viral infections in urban children with asthma
Lewis T, Metitiri E, Mentz G, Ren X, Goldsmith A, Eder B, Wicklund K, Walsh M, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M, SteeringCommittee T. Impact of community respiratory viral infections in urban children with asthma. Annals Of Allergy Asthma & Immunology 2018, 122: 175-183.e2. PMID: 30385348, PMCID: PMC6360098, DOI: 10.1016/j.anai.2018.10.021.Peer-Reviewed Original ResearchConceptsRespiratory viral infectionsViral infectionBiomarker elevationAirway functionSymptom scoresUpper respiratory tract viral infectionC-C motif chemokine ligand (CCL)-2Fraction of exhaled nitric oxideRespiratory tract viral infectionsRespiratory illnessUpper respiratory viral infectionReduced airway functionC-X-C motif chemokine ligandUpper respiratory tract symptomsExhaled nitric oxideMelanoma differentiation-associated protein 5Respiratory tract symptomsRespiratory tract inflammationCold-like illnessMotif chemokine ligandNormal airway functionSelf-reported respiratory illnessChemokine levelsForced expiratory flowNasal biomarkers