2024
Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study
Jang D, Dou J, Koubek E, Teener S, Zhou L, Bakulski K, Mukherjee B, Batterman S, Feldman E, Goutman S. Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study. Journal Of Neurology Neurosurgery & Psychiatry 2024, jnnp-2024-333978. PMID: 39107037, DOI: 10.1136/jnnp-2024-333978.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosis riskEnvironmental risk scoreAssociated with ALS riskALS riskGenetic riskRisk scorePolygenic risk scoresSelf-reported exposureGenome-wide association studiesStudy investigated associationsCase-control studySingle-nucleotide polymorphismsAssociation studiesExposure mixturesControl participantsExposure sourcesRiskParticipantsAmyotrophic lateral sclerosisSurvival modelsScoresAssociationEnvironmental factorsUrine metalsUrine samplesDecomposing the association of psychosocial wellbeing with all-cause mortality: the mediating role of physical health and lifestyle factors
Alimujiang A, Strecher V, McLean K, Mondul A, Pearce C, Mukherjee B. Decomposing the association of psychosocial wellbeing with all-cause mortality: the mediating role of physical health and lifestyle factors. Social Psychiatry And Psychiatric Epidemiology 2024, 1-11. PMID: 39044017, DOI: 10.1007/s00127-024-02717-y.Peer-Reviewed Original ResearchLifestyle factorsPhysical healthWellbeing groupsPsychosocial wellbeingU.S. Health and Retirement StudyEffects of physical healthHealth and Retirement StudyTotal effectHealth index measureMediation analysisMethodsLatent class analysisRetirement StudyPsychosocial constructsSignificant total effectsLifestyleHealthPurposeThis studyClass analysisConclusionOur findingsWellbeingSummation effectMortalityGroupParticipantsFactorsThe mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia
Higgins Tejera C, Ware E, Hicken M, Kobayashi L, Wang H, Blostein F, Zawistowski M, Mukherjee B, Bakulski K. The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia. Communications Medicine 2024, 4: 142. PMID: 39003383, PMCID: PMC11246521, DOI: 10.1038/s43856-024-00569-w.Peer-Reviewed Original ResearchIncident dementiaRacial disparitiesRisk of incident dementiaCumulative incidence of dementiaNon-Hispanic white participantsIncidence of dementiaControlled direct effectExposure to racismDementia incidenceDementia burdenUS HealthC-reactive proteinWhite participantsLower C-reactive proteinHigh C-reactive proteinDementiaHigher CRP levelsCognitive testsDisparitiesSystemic racismGroup membershipFollow-upParticipantsModerate portionGroup statusText Messages to Promote Physical Activity in Patients With Cardiovascular Disease: A Micro-Randomized Trial of a Just-In-Time Adaptive Intervention
Golbus J, Shi J, Gupta K, Stevens R, Jeganathan V, Luff E, Boyden T, Mukherjee B, Kohnstamm S, Taralunga V, Kheterpal V, Kheterpal S, Resnicow K, Murphy S, Dempsey W, Klasnja P, Nallamothu B. Text Messages to Promote Physical Activity in Patients With Cardiovascular Disease: A Micro-Randomized Trial of a Just-In-Time Adaptive Intervention. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010731. PMID: 38887953, PMCID: PMC11251861, DOI: 10.1161/circoutcomes.123.010731.Peer-Reviewed Original ResearchIncreased step countsCardiac rehabilitationPhysical activityMicro-randomized trialStep countsText messagesLow-level physical activityEffects of text messagingPromote physical activityPhysical activity levelsTailored text messagesIncreased physical activityJust-in-time adaptive interventionsCardiovascular diseaseSignificant 6% increaseEstimate causal effectsActivity levelsRehabilitationPrimary outcomeApple WatchContextual factorsAdaptive interventionsParticipantsCausal effectsLong-term effectsAvocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study
Goutman S, Boss J, Jang D, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman E, Batterman S. Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. Journal Of The Neurological Sciences 2024, 457: 122899. PMID: 38278093, PMCID: PMC11060628, DOI: 10.1016/j.jns.2024.122899.Peer-Reviewed Original ResearchConceptsALS riskLower educational attainmentAssociated with ALS riskCase-control studyExercise 5Onset ageSelf-completionExposure variablesYard workExposure associationsRecreational danceIdentified exposureExerciseEducational attainmentAL burdenEnvironmental exposuresParticipantsAL factorPersonal participationAvocational exposureRiskExposomeHobbiesALS onsetComparison correction
2023
A randomized trial of a mobile health intervention to augment cardiac rehabilitation
Golbus J, Gupta K, Stevens R, Jeganathan V, Luff E, Shi J, Dempsey W, Boyden T, Mukherjee B, Kohnstamm S, Taralunga V, Kheterpal V, Murphy S, Klasnja P, Kheterpal S, Nallamothu B. A randomized trial of a mobile health intervention to augment cardiac rehabilitation. Npj Digital Medicine 2023, 6: 173. PMID: 37709933, PMCID: PMC10502072, DOI: 10.1038/s41746-023-00921-9.Peer-Reviewed Original ResearchCentre-based cardiac rehabilitationMHealth interventionsCentre-based CRPhysical activity levelsMobile health interventionsPositive health behaviorsPrimary outcomeCR careIntervention participantsRandomized trialsCardiac rehabilitationModerate risk patientsHealth behaviorsMobile healthHealth interventionsHealth systemWalking distanceText messagesMHealthActivity levelsRandomized clinical trialsSecondary outcomesInterventionParticipantsHealthCohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data
Salvatore M, Clark-Boucher D, Fritsche L, Ortlieb J, Houghtby J, Driscoll A, Caldwell-Larkins B, Smith J, Brummett C, Kheterpal S, Lisabeth L, Mukherjee B. Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data. Epidemiology And Health 2023, 45: e2023074. PMID: 37591787, PMCID: PMC10867525, DOI: 10.4178/epih.e2023074.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsSelf-reported health dataFamily health historyEpidemiological questionnaireCancer screeningHealth cohortHealth SurveyHealth historyFinancial toxicityBaseline surveyEHR dataHealth dataCohort dataEPI-QAverage ageOccupational exposureGenotype dataParticipantsGenotype informationInstitutional review board approvalResponse rateCohortLife meaningQuestionnaire
2017
Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases
McAllister K, Mechanic L, Amos C, Aschard H, Blair I, Chatterjee N, Conti D, Gauderman W, Hsu L, Hutter C, Jankowska M, Kerr J, Kraft P, Montgomery S, Mukherjee B, Papanicolaou G, Patel C, Ritchie M, Ritz B, Thomas D, Wei P, Witte J, participants O. Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. American Journal Of Epidemiology 2017, 186: 753-761. PMID: 28978193, PMCID: PMC5860428, DOI: 10.1093/aje/kwx227.Peer-Reviewed Original ResearchConceptsGene-environment interaction studiesStudies of complex diseasesGene-environmentAmerican Society of Human Genetics meetingMeasures of environmental exposureGene-environment interactionsComplex diseasesNational Institute of Environmental Health SciencesNational Cancer InstituteEnvironmental Health SciencesStudy designHealth SciencesCancer InstituteEnvironmental exposuresEnvironmental exposure assessmentNational InstituteLarge-scale studiesExposure assessmentNext-generation sequencing dataDisease outcomeNationalSequence dataThemesStudies of human populationsParticipants