2024
Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study
Siwakoti R, Park S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study. Chemosphere 2024, 360: 142363. PMID: 38768789, PMCID: PMC11487489, DOI: 10.1016/j.chemosphere.2024.142363.Peer-Reviewed Original ResearchFetal sexMaternal raceEffect modificationOS biomarkersOxidative stressPre-pregnancy BMIAdverse pregnancy outcomesNo significant effect modificationMaternal oxidative stressPlasma PFASsSignificant effect modificationInterquartile range increasePositive associationExposure to OSPre-pregnancyPregnancy outcomesMaternal ageMultivariate linear regressionSex-specific effectsLinear mixed-effects modelsPotential confoundersInsurance statusRange increaseEndocrine functionEducation level
2021
Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposure
2019
Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates
Ferguson K, Lan Z, Yu Y, Mukherjee B, McElrath T, Meeker J. Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates. Environment International 2019, 131: 104903. PMID: 31288179, PMCID: PMC6728185, DOI: 10.1016/j.envint.2019.104903.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesOxidative stress biomarkersNon-null associationsPhthalate metabolitesBiomarkers of oxidative stressInterquartile rangeBenzophenone-3Associated with increasesOutcome biomarkersIncreased maternal oxidative stressStress biomarkersExposure to environmental phenolsOxidative stressReduced fetal growthUrinary oxidative stress biomarkersMaternal oxidative stressEffect estimatesAdaptive elastic net modelStudy populationPreterm birthFetal growthConcentration of phenolUrinary phenolPregnancyUrinary concentrationsCorrigendum to “Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy” [Reprod. Toxicol. 66 (2016) 93–98]
Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Corrigendum to “Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy” [Reprod. Toxicol. 66 (2016) 93–98]. Reproductive Toxicology 2019, 90: 166. PMID: 31126749, DOI: 10.1016/j.reprotox.2019.04.003.Peer-Reviewed Original ResearchErratum: “Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis”
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Erratum: “Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis”. Environmental Health Perspectives 2019, 127: 019001. PMID: 30620211, PMCID: PMC6371643, DOI: 10.1289/ehp4854.Peer-Reviewed Original Research
2018
Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study
Wang W, Moroi S, Bakulski K, Mukherjee B, Weisskopf M, Schaumberg D, Sparrow D, Vokonas P, Hu H, Park S. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives 2018, 126: 087002. PMID: 30102601, PMCID: PMC6108844, DOI: 10.1289/ehp3442.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIncident primary open-angle glaucomaRisk of primary open-angle glaucomaOpen-angle glaucomaHazard ratioIncident cases of POAGCases of primary open-angle glaucomaAsymmetric cup-to-disc ratioFollow-upPrimary open-angle glaucoma casesEtiology of primary open-angle glaucomaCup-to-disc ratioVisual field defectsCox proportional hazards regressionAssociated with hazard ratiosProportional hazards regressionOxidative stressEstimate hazard ratiosDisc hemorrhageOcular evaluationPatella leadField defectsCumulative lead doseProspective cohortSurvival curvesAssociations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy
Ferguson K, Kamai E, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy. American Journal Of Reproductive Immunology 2018, 80: e13017. PMID: 29984454, PMCID: PMC6160349, DOI: 10.1111/aji.13017.Peer-Reviewed Original ResearchConceptsAssociated with reduced fetal growthFetal growthAssociated with poorer childAdult health outcomesOxidative stress markersBirth cohort studyInterquartile rangeAssociated with head circumferenceRepeated-measures modelFetal weight z-scoreAssociated with fetal weightOxidative stressHealth outcomesStandard deviation decreaseWeight z-scoreStress markersSecondary analysisMaternal oxidative stressCohort studyZ-scoreFetal weightMaternal inflammationDeviation decreasePreterm birthHead circumference
2016
Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies
Ferguson K, Meeker J, McElrath T, Mukherjee B, Cantonwine D. Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. American Journal Of Obstetrics And Gynecology 2016, 216: 527.e1-527.e9. PMID: 28043842, PMCID: PMC5420472, DOI: 10.1016/j.ajog.2016.12.174.Peer-Reviewed Original ResearchConceptsTumor necrosis factor-aNormotensive pregnanciesC-reactive proteinMeasures of inflammationHazard ratioOxidative stress biomarkersInterleukin-1bTime pointsInflammation biomarkersStudy visitsTime of preeclampsia diagnosisPrediction of preeclampsiaOxidative stressHigher body mass indexOxidative stress biomarker 8-isoprostaneStress biomarkersCox proportional hazards modelsCompared to other time pointsBody mass indexProspective birth cohortCalculate hazard ratiosSmall study populationPanel of inflammationFactor AProportional hazards modelRepeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy
Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reproductive Toxicology 2016, 66: 93-98. PMID: 27751756, PMCID: PMC5125888, DOI: 10.1016/j.reprotox.2016.10.002.Peer-Reviewed Original ResearchConceptsInterquartile range increaseBisphenol AOxidative stressRange increaseUrinary bisphenol A concentrationsC-reactive proteinBiomarkers of inflammationIL-6 concentrationsAdverse birth outcomesPrimary mechanism of actionAssociated with significant increasesRepeated measures analysisBisphenol A exposureBiomarkers of oxidative stressBisphenol A concentrationsMechanism of actionPregnant womenFetal developmentImpact pregnancyInflammation markersBirth outcomesOxidative stress biomarkersIL-6BPA exposurePregnancyMediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociation
2014
Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2014, 123: 210-216. PMID: 25402001, PMCID: PMC4348741, DOI: 10.1289/ehp.1307996.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesMono-n-butyl phthalateBiomarkers of oxidative stressBirth outcomesNested case-control study of preterm birthCase-control study of preterm birthPhthalate exposureStudy of preterm birthStudy of birth outcomesOxidative stressPopulation of pregnant womenNested case-control studyStudy population of pregnant womenAdverse birth outcomesUrine samplesMarkers of oxidative stressRepeated measures analysisHealth end pointsAssociated with significantly higher concentrationsDi(2-ethylhexyl) phthalatePreterm birthPregnant womenMono-n-butylLinear mixed modelsRepeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth
Ferguson K, McElrath T, Chen Y, Loch-Caruso R, Mukherjee B, Meeker J. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal Of Obstetrics And Gynecology 2014, 212: 208.e1-208.e8. PMID: 25111586, PMCID: PMC4312513, DOI: 10.1016/j.ajog.2014.08.007.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthAssociated with increased odds of spontaneous preterm birthCases of spontaneous preterm birthOdds of spontaneous preterm birthPathways to preterm birthMechanisms of preterm birthNested case-control studyLevels of 8-isoprostaneOxidative stressUrinary biomarkers of oxidative stressConcentrations of 8-isoprostaneUrinary oxidative stress biomarkersLevels of 8-OHdGMaternal oxidative stressCase-control studyProspective birth cohortUrinary 8-OHdG concentrationsAssociated with increased oddsInvestigate oxidative stressDelivered pretermBiomarkers of oxidative stressPlacental originUrinary concentrations of 8-isoprostanePretermUrinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico
Ferguson K, Cantonwine D, Rivera-González L, Loch-Caruso R, Mukherjee B, Del Toro L, Jiménez-Vélez B, Calafat A, Ye X, Alshawabkeh A, Cordero J, Meeker J. Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico. Environmental Science And Technology 2014, 48: 7018-7025. PMID: 24845688, PMCID: PMC4066910, DOI: 10.1021/es502076j.Peer-Reviewed Original ResearchConceptsMono-n-butyl phthalateBiomarkers of inflammationIL-10Prospective cohort study of pregnant womenDi-2-ethylhexyl phthalate metabolitesCohort study of pregnant womenIL-6Study of pregnant womenAssociated with increased IL-6Oxidative stressUrinary phthalate metabolitesC-reactive proteinProspective cohort studyAdverse birth outcomesMetabolites of di-2-ethylhexyl phthalateOxidative stress markersPreterm birthMetabolite associationsPregnant womenMono-n-butylDi-2-ethylhexyl phthalateOxidative stress biomarkersBirth outcomesTNF-aInflammation biomarkers
2013
Associations between urinary phthalate metabolites and biomarkers of inflammation and oxidative stress in pregnant women
Ferguson K, Mukherjee B, McElrath T, Meeker J. Associations between urinary phthalate metabolites and biomarkers of inflammation and oxidative stress in pregnant women. ISEE Conference Abstracts 2013, 2013 DOI: 10.1289/isee.2013.o-4-26-05.Peer-Reviewed Original Research