2022
ExPRSweb: An online repository with polygenic risk scores for common health-related exposures
Ma Y, Patil S, Zhou X, Mukherjee B, Fritsche L. ExPRSweb: An online repository with polygenic risk scores for common health-related exposures. American Journal Of Human Genetics 2022, 109: 1742-1760. PMID: 36152628, PMCID: PMC9606385, DOI: 10.1016/j.ajhg.2022.09.001.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresChronic conditionsPhenome-wide association studyMichigan Genomics InitiativeRisk scoreAssociation studiesHealth-related exposuresGenome-wide association studiesUK BiobankGenetic risk factorsPRS methodsFollow-up studyRisk factorsComplex traitsGenome InitiativeGenetic modifiersBiobankInfluence of exposureEnvironmental variablesScoresLipid levelsExpRLifestyleSmokingOnline repository
2020
Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
Fritsche L, Patil S, Beesley L, VandeHaar P, Salvatore M, Ma Y, Peng R, Taliun D, Zhou X, Mukherjee B. Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks. American Journal Of Human Genetics 2020, 107: 815-836. PMID: 32991828, PMCID: PMC7675001, DOI: 10.1016/j.ajhg.2020.08.025.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresGenome-wide association studiesMichigan Genomics InitiativeUK BiobankPopulation-based UK BiobankPolygenic risk score constructionPublished genome-wide association studiesLongitudinal biorepository effortAssociation studiesPredictive polygenic risk scoresRisk scoreNHGRI-EBI GWAS CatalogCancer traitsIndependent biobankMichigan MedicineGWAS CatalogGenome InitiativeBiobankScoresTraitsCancer researchOnline repositoryMichiganMedicineEvaluation