2022
Predicting cumulative lead (Pb) exposure using the Super Learner algorithm
Wang X, Bakulski K, Mukherjee B, Hu H, Park S. Predicting cumulative lead (Pb) exposure using the Super Learner algorithm. Chemosphere 2022, 311: 137125. PMID: 36347347, PMCID: PMC10160242, DOI: 10.1016/j.chemosphere.2022.137125.Peer-Reviewed Original ResearchConceptsPatella leadNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyLong-term health effectsPopulation-based studyK-shell X-ray fluorescenceNormative Aging StudyCumulative lead exposureEvaluate health effectsExamination SurveyLead concentrationsBone lead measurementsAging StudyTibia leadPositive associationStudy populationHealth effectsRegression-based predictive modelBone lead concentrationsBlood pressureFlexible machine learning approachCorrelation coefficientX-ray fluorescence techniqueLead measurements
2017
Exposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction
Sun Z, Mukherjee B, Estes J, Vokonas P, Park S. Exposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction. Statistics In Medicine 2017, 36: 2947-2960. PMID: 28497531, PMCID: PMC5523112, DOI: 10.1002/sim.7332.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyCase-only designLongitudinal studyG x E interactionNormative Aging StudyComplete-case analysisGene-environmentSampling designCase-controlVeterans AdministrationComplex human diseasesE interactionExposure informationAging StudyOutcome trajectoriesStratified samplingRetrospective genotypingIndividual exposureCovariate dataExposure effectsJoint effectsOutcomesTime-varying outcomeEnvironmental factors
2014
Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting
Ko Y, Mukherjee B, Smith J, Park S, Kardia S, Allison M, Vokonas P, Chen J, Diez‐Roux A. Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting. Statistics In Medicine 2014, 33: 5177-5191. PMID: 25112650, PMCID: PMC4227925, DOI: 10.1002/sim.6281.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAtherosclerosisBone and BonesComputer SimulationEnvironmental ExposureEthnicityFemaleGene-Environment InteractionHumansIronLeadLeast-Squares AnalysisLikelihood FunctionsLongitudinal StudiesMaleMiddle AgedModels, GeneticUnited StatesUnited States Department of Veterans AffairsConceptsGene-environment interactionsMulti-Ethnic Study of AtherosclerosisModel of gene-environment interactionMulti-Ethnic StudyTukey's modelLongitudinal settingStudy of AtherosclerosisNormative Aging StudyCase-control studyIncreasing categoriesAging StudyTested interactionsLongitudinal studyCategorical variablesRobust to misspecificationInteraction termsTest departuresShrinkage estimatorsWald testInteraction estimatesIncreased powerOne-degree-of-freedom modelInteraction effectsSetsEnvironmental markers
2013
Propensity score‐based diagnostics for categorical response regression models
Boonstra P, Bondarenko I, Park S, Vokonas P, Mukherjee B. Propensity score‐based diagnostics for categorical response regression models. Statistics In Medicine 2013, 33: 455-469. PMID: 23934948, PMCID: PMC3911784, DOI: 10.1002/sim.5940.Peer-Reviewed Original ResearchConceptsRetrospective sampling designsChi-square distributionCategorical response modelsGoodness-of-fit statisticsPredicted response probabilitiesResponse regression modelsConditional distributionProportional odds modelAssess model adequacyData examplesSimulation studyVA Normative Aging StudyNormative Aging StudyPropensity scoreCumulative lead exposureOdds modelModel diagnosticsCase-control studyAssociated with diabetesBalance scoresResponse probabilityModel adequacyCohort studyAging StudyNumerical summariesNovel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data
Ko Y, Saha‐Chaudhuri P, Park S, Vokonas P, Mukherjee B. Novel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data. Genetic Epidemiology 2013, 37: 581-591. PMID: 23798480, PMCID: PMC4009698, DOI: 10.1002/gepi.21744.Peer-Reviewed Original ResearchConceptsGene-environment interactionsGene-gene interactionsTesting gene-gene interactionsModel gene-gene interactionsRepeated-measures studyLongitudinal cohort studyNormative Aging StudyCumulative lead exposureCase-control studyGene-environmentGene-geneType I error rateCohort studyScreening toolAging StudyLikelihood ratio testMain effectEpistasis patternsRatio testLead exposureHemochromatosis genePower propertiesPulse pressureRegression-based approachRestrictive assumptions
2012
Principal interactions analysis for repeated measures data: application to gene–gene and gene–environment interactions
Mukherjee B, Ko Y, VanderWeele T, Roy A, Park S, Chen J. Principal interactions analysis for repeated measures data: application to gene–gene and gene–environment interactions. Statistics In Medicine 2012, 31: 2531-2551. PMID: 22415818, PMCID: PMC4046647, DOI: 10.1002/sim.5315.Peer-Reviewed Original ResearchConceptsGene-environment interactionsGene-geneLongitudinal cohort studyNormative Aging StudyHealth outcomesMain effect termsMeasured outcomesAging StudyOccupational historyEpistasis modelsEnvironmental exposuresMain effectLongitudinal natureLongitudinal dataResampling-based methodsCell meansClassification arrayQuantitative traitsInteraction analysisRobust classLeading eigenvaluesSimulation studyTime-varying effectsSubject-specificOutcomes
2011
Cumulative Exposure to Lead is associated with Increased Risk of Type-2 Diabetes: the VA Normative Aging Study (NAS)
Huang S, Park S, Mukherjee B, Nie H, Sparrow D, Hu H. Cumulative Exposure to Lead is associated with Increased Risk of Type-2 Diabetes: the VA Normative Aging Study (NAS). ISEE Conference Abstracts 2011, 2011 DOI: 10.1289/isee.2011.01547.Peer-Reviewed Original Research
2010
Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study
Park S, Elmarsafawy S, Mukherjee B, Spiro A, Vokonas P, Nie H, Weisskopf M, Schwartz J, Hu H. Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study. Hearing Research 2010, 269: 48-55. PMID: 20638461, PMCID: PMC2934752, DOI: 10.1016/j.heares.2010.07.004.Peer-Reviewed Original ResearchConceptsAge-related hearing lossPure-tone averagePatella lead levelsCumulative lead exposureHearing lossHearing thresholdsNormative Aging StudyAssociated with poorer hearing thresholdsOdds of hearing lossAir conduction hearing thresholdsAssociated with hearing lossConduction hearing thresholdsPoorer hearing thresholdsAging StudyDevelopment of age-related hearing lossReduction of lead exposureVA Normative Aging StudyCross-sectional analysisLead exposureOccupational noiseHearing abilityK X-ray fluorescencePotential confoundersEpidemiological researchLead levelsHFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study
Zhang A, Park S, Wright R, Weisskopf M, Mukherjee B, Nie H, Sparrow D, Hu H. HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study. Environmental Health Perspectives 2010, 118: 1261-1266. PMID: 20478760, PMCID: PMC2944087, DOI: 10.1289/ehp.1002251.Peer-Reviewed Original ResearchConceptsCumulative lead exposureHFE H63D polymorphismC282Y variantBone lead levelsAssociated with steeper increasesLinear mixed-effects regression modelsFamily history of hypertensionMixed-effects regression modelsDaily intake of calciumNormative Aging StudyPredictor of cardiovascular diseaseWaist circumferenceIntake of calciumHistory of hypertensionLead exposureH63D polymorphismAlcohol intakeRandom interceptFamily historyMarker of arterial stiffnessTotal caloriesAging StudySteeper increasesLead levelsCardiovascular disease
2009
The H63D Mutation in the Hemochromatosis (HFE) Gene Modifies the Impact of Bone Lead (Pb) Burden on Pulse Pressure (PP): The VA Normative Aging Study (NAS)
Zhang A, Park S, Wright R, Mukherjee B, Sparrow D, Vokonas P, Nie H, Hu H. The H63D Mutation in the Hemochromatosis (HFE) Gene Modifies the Impact of Bone Lead (Pb) Burden on Pulse Pressure (PP): The VA Normative Aging Study (NAS). Epidemiology 2009, 20: s114. DOI: 10.1097/01.ede.0000362395.97915.0e.Peer-Reviewed Original ResearchNormative Aging Study
2008
The Impact of Occupation-Related Noise Exposure on Hearing Thresholds in Middle-Aged and Elderly Men: The Normative Aging Study
Choi Y, Hu H, Weisskopf M, Mukherjee B, Sparrow D, Spiro A, Tak S, Park S. The Impact of Occupation-Related Noise Exposure on Hearing Thresholds in Middle-Aged and Elderly Men: The Normative Aging Study. Epidemiology 2008, 19: s276-s277. DOI: 10.1097/01.ede.0000340305.17534.65.Peer-Reviewed Original ResearchNormative Aging StudyHearing thresholdsNoise exposureMiddle-agedElderly MenAging StudyHearingEldersMenAssociation between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study
Lampe B, Park S, Robins T, Mukherjee B, Litonjua A, Amarasiriwardena C, Weisskopf M, Sparrow D, Hu H. Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study. Environmental Health Perspectives 2008, 116: 1226-1230. PMID: 18795167, PMCID: PMC2535626, DOI: 10.1289/ehp.11265.Peer-Reviewed Original ResearchConceptsSmoking statusCommunity-based study of agingAssessed effect modificationForced vital capacityPulmonary functionCommunity-based studyAssociated with forced expiratory volumeStudy of AgingFEV(1)/FVC ratioCadmium exposureUrinary cadmiumNormative Aging StudyEffect modificationEnvironmental cadmium exposureLevels of cadmium exposureAssociated with reduced pulmonary functionTests of pulmonary functionMixed-effects modelsAging StudyChronic cadmium exposureSmokingCadmium body burdenForced expiratory volumeCigarette smokingLog unit increase