2024
Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort
Siwakoti R, Harris S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort. Environment International 2024, 194: 109145. PMID: 39550829, DOI: 10.1016/j.envint.2024.109145.Peer-Reviewed Original ResearchC-reactive proteinNested case-control study of preterm birthCase-control study of preterm birthInflammatory biomarkersIL-10TNF-aInterquartile range increaseNested case-control studyStudy of preterm birthPre-pregnancy BMIQuantile-based g-computation approachIL-6Prenatal PFAS exposureInflammatory processPregnancy plasma samplesMeasurement of inflammatory biomarkersBirth outcomesLinear mixed modelsInverse associationRange increaseMaternal raceMaternal demographicsTNF-a levelsAdverse pregnancyAfrican Americans
2017
Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis
Johns L, Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2017, 125: 087026. PMID: 28934718, PMCID: PMC5783673, DOI: 10.1289/ehp1178.Peer-Reviewed Original ResearchConceptsCohort of pregnant womenMono-3-carboxypropyl phthalateVitamin D levelsPregnant womenD levelsNested case-control study of preterm birthMeasures of urinary phthalate metabolitesProspective cohort of pregnant womenOdds of vitamin D deficiencyCase-control study of preterm birthDi(2-ethylhexyl) phthalate metabolitesInverse associationStudy of preterm birthInterquartile rangePlasma vitamin D levelsCirculating total 25(OH)DNested case-control studyMetabolites of di(2-ethylhexyl) phthalateVitamin D deficiencyDi(2-ethylhexyl) phthalatePhthalate metabolite concentrationsUrinary phthalate metabolitesUrinary bisphenol AProspective birth cohortPreterm birthThyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study
Aung M, Johns L, Ferguson K, Mukherjee B, McElrath T, Meeker J. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environment International 2017, 104: 33-40. PMID: 28410473, PMCID: PMC5497503, DOI: 10.1016/j.envint.2017.04.001.Peer-Reviewed Original ResearchConceptsThyroid hormone parametersHormonal parametersStudy visitsCases of preterm birthInterquartile rangeSupply of thyroid hormonesNormal birth outcomesUrinary bisphenol A concentrationsNested case-control studyThyrotropin (TSHContext of pregnancyUrinary BPA concentrationsUrinary bisphenol ACase-control studyIn vitro studiesPreterm birthTSH levelsMultivariate linear regression modelPregnant womenFetal developmentFree T4Visit 3Measures analysisBirth outcomesPregnancyLongitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth
Johns L, Ferguson K, McElrath T, Mukherjee B, Seely E, Meeker J. Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth. PLOS ONE 2017, 12: e0169542. PMID: 28060899, PMCID: PMC5217954, DOI: 10.1371/journal.pone.0169542.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthNested case-control study of preterm birthThyroid hormonesSubclinical alterationsPregnant womenCase-control study of preterm birthThyroid diseaseOdds of preterm birthOngoing birth cohort studyNested case-control studyStudy of preterm birthAssociated with preterm birthBirth cohort studyTime pointsMultivariate logistic regression modelOverall preterm birthSpontaneous preterm birthWeeks of gestationClinical thyroid diseaseOvert thyroid diseaseThyroid hormone parametersMaternal thyroid hormone concentrationsMaternal thyroid hormonesLogistic regression models
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociationUrinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia
Cantonwine D, Meeker J, Ferguson K, Mukherjee B, Hauser R, McElrath T. Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia. Environmental Health Perspectives 2016, 124: 1651-1655. PMID: 27177253, PMCID: PMC5047771, DOI: 10.1289/ehp188.Peer-Reviewed Original ResearchRisk of preeclampsiaUrinary concentrations of BPAUrinary concentrations of bisphenol APhthalate metabolitesUrinary concentrationsAssociated with increased risk of preeclampsiaHazard ratioCases of preeclampsiaNested case-control studyDevelopment of preeclampsiaProspective birth cohort studyAssociated with increased riskPhthalate metabolite concentrationsCox proportional hazards modelsAdjusted Cox proportional hazards modelsCase-control studyAdjusted hazard ratiosCalculate hazard ratiosProportional hazards modelBirth cohort studyWeeks gestationPreterm birthAssociated with onsetPreeclampsiaUrinary BPAAssociations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy
Johns L, Ferguson K, McElrath T, Mukherjee B, Meeker J. Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy. Environmental Health Perspectives 2016, 124: 1808-1815. PMID: 27152641, PMCID: PMC5089879, DOI: 10.1289/ehp170.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesMaternal urinary phthalate metabolitesThyroid hormone parametersThyroid hormone levelsPregnant womenPhthalate metabolitesStudy visitsHormonal parametersNested case-control study of preterm birthMeasures of urinary phthalate metabolitesHormone levelsCase-control study of preterm birthStudy of preterm birthThyroid hormonesEnvironmental phthalate exposureNested case-control studyNormal thyroid functionLevels of thyroid hormonesThyroid function markersTime pointsCirculating levels of thyroid hormonesTotal thyroid hormonesPreterm birthFetal growthPlasma thyroid hormone levels
2015
Urinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth
Cantonwine D, Ferguson K, Mukherjee B, McElrath T, Meeker J. Urinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth. Environmental Health Perspectives 2015, 123: 895-901. PMID: 25815860, PMCID: PMC4559950, DOI: 10.1289/ehp.1408126.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthBisphenol A exposurePreterm premature rupture of membranesClinical classificationClassification of preterm birthSubcategories of preterm birthPremature rupture of membranesBisphenol A levelsCases of preterm birthAssociated with preterm birthSpontaneous preterm laborPreterm premature ruptureRupture of membranesSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProspective birth cohort studyUrinary bisphenol ACase-control studyAssociated with increased oddsA levelsTertiary teaching hospitalBirth cohort studyDelivered pretermStatistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth
Chen Y, Ferguson K, Meeker J, McElrath T, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015, 14: 9. PMID: 25619201, PMCID: PMC4417225, DOI: 10.1186/1476-069x-14-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersBostonCase-Control StudiesCross-Sectional StudiesData Interpretation, StatisticalEnvironmental ExposureFemaleHazardous SubstancesHumansInfant, NewbornMaternal ExposureMiddle AgedModels, StatisticalPhthalic AcidsPregnancyPremature BirthSocioeconomic FactorsYoung AdultConceptsPreterm birthEnvironmental chemical exposuresMeasures of urinary phthalate metabolitesNested case-control studyCross-sectional analysisAverage exposureMeasures of exposureCase-control studyUrinary phthalate metabolitesModel repeated measuresEpidemiological research projectsLongitudinal exposureRepeated measuresPremature birthPretermEnvironmental exposure biomarkersExposure measurementsUrinary metabolitesMaternal factorsPhthalate metabolitesPregnancyStudy of phthalatesLongitudinal predictorsChemical exposureBirth
2014
Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2014, 123: 210-216. PMID: 25402001, PMCID: PMC4348741, DOI: 10.1289/ehp.1307996.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesMono-n-butyl phthalateBiomarkers of oxidative stressBirth outcomesNested case-control study of preterm birthCase-control study of preterm birthPhthalate exposureStudy of preterm birthStudy of birth outcomesOxidative stressPopulation of pregnant womenNested case-control studyStudy population of pregnant womenAdverse birth outcomesUrine samplesMarkers of oxidative stressRepeated measures analysisHealth end pointsAssociated with significantly higher concentrationsDi(2-ethylhexyl) phthalatePreterm birthPregnant womenMono-n-butylLinear mixed modelsRepeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth
Ferguson K, McElrath T, Chen Y, Loch-Caruso R, Mukherjee B, Meeker J. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal Of Obstetrics And Gynecology 2014, 212: 208.e1-208.e8. PMID: 25111586, PMCID: PMC4312513, DOI: 10.1016/j.ajog.2014.08.007.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthAssociated with increased odds of spontaneous preterm birthCases of spontaneous preterm birthOdds of spontaneous preterm birthPathways to preterm birthMechanisms of preterm birthNested case-control studyLevels of 8-isoprostaneOxidative stressUrinary biomarkers of oxidative stressConcentrations of 8-isoprostaneUrinary oxidative stress biomarkersLevels of 8-OHdGMaternal oxidative stressCase-control studyProspective birth cohortUrinary 8-OHdG concentrationsAssociated with increased oddsInvestigate oxidative stressDelivered pretermBiomarkers of oxidative stressPlacental originUrinary concentrations of 8-isoprostanePretermLongitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy. American Journal Of Reproductive Immunology 2014, 72: 326-336. PMID: 24807462, PMCID: PMC4573571, DOI: 10.1111/aji.12265.Peer-Reviewed Original ResearchConceptsPreterm birthC-reactive proteinAssociated with increased oddsInflammation markersAssociated with increased odds of spontaneous preterm birthIL-10Associated with increased risk of preterm birthOdds of spontaneous preterm birthEtiology of preterm deliveryPredictors of preterm birthIL-6Risk of preterm birthPreterm premature ruptureSpontaneous preterm laborSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProfile of inflammatory cytokinesAssociated with increased riskCase-control studyPreterm laborPreterm pregnanciesPreterm deliveryGestational agePremature rupture