2022
Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 317: 120740. PMID: 36436662, PMCID: PMC9897061, DOI: 10.1016/j.envpol.2022.120740.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsExposure to heavy metalsHeavy metalsMetal concentrationsStudy of Women's HealthAssociation of heavy metalsEnvironmental heavy metal exposureHeavy metal exposureSex hormone-binding globulinFollicle-stimulating hormoneWomen's HealthBayesian kernel machine regressionAssociated with E<sub>2</sub>, TMidlife womenKernel machine regressionMetal exposureSerum hormone levelsMetal mixturesHealth-related factorsNation Multi-Pollutant StudyCalculate percent changesCadmiumHormone levelsProspective cohort studyLinear mixed effects modelsPer- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Ding N, Karvonen-Gutierrez C, Calafat A, Herman W, Mukherjee B, Harlow S. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022, 65: 1157-1168. PMID: 35399113, PMCID: PMC9177697, DOI: 10.1007/s00125-022-05695-5.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncident diabetesWomen's HealthPolyfluoroalkyl substancesDiabetes riskMidlife womenSelf-reported diabetesTotal energy intakeProspective cohort studyIncreased diabetes riskCox proportional hazards modelsPhysical activityGlucose-lowering medicationsProportional hazards modelResultsAfter adjustmentNation Multi-Pollutant StudyBottom tertileSmoking statusHighest tertileAlcohol consumptionDiabetes-free womenFollow-up visitG-computationQuantile-based g-computationCohort studyRace-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 303: 119164. PMID: 35306088, PMCID: PMC9883839, DOI: 10.1016/j.envpol.2022.119164.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthBayesian kernel machine regressionWomen's HealthLeptin levelsBlack womenAssociated with lower leptinAssociated with favorable profilesAsian womenSoluble leptin receptorRacial differencesRace-specific associationsUrinary phenolCross-sectional associationsNo significant associationObesity-related metabolic diseasesLog-transformed levelsSOB-RKernel machine regressionSerum adipokinesMetabolic disease burdenEffect modificationNation Multi-Pollutant StudyLow leptinLeptin receptorLinear regression modelsMetals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States. Environmental Research 2022, 210: 112976. PMID: 35202625, PMCID: PMC9869389, DOI: 10.1016/j.envres.2022.112976.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreCohort of midlife womenIncident MetSMidlife womenHazard ratioRisk of incident MetSRisk of incident metabolic syndromeProspective cohortStudy of Women's HealthFree of MetSRisk of cardiometabolic diseasesIncident metabolic syndromeMetabolic syndromeImpaired fasting glucoseCox proportional hazards modelsHigh-density lipoprotein cholesterolHigh blood pressureMetS incidenceWomen's HealthProportional hazards modelAbdominal obesityNation Multi-Pollutant StudyDevelopment of metabolic syndromeCardiometabolic diseasesHigh triglycerides
2021
Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation. Environment International 2021, 157: 106781. PMID: 34311223, PMCID: PMC8490279, DOI: 10.1016/j.envint.2021.106781.Peer-Reviewed Original ResearchConceptsMetal mixturesMetal concentrationsTiming of natural menopauseCox proportional hazards modelsNatural menopauseStudy of Women's HealthProportional hazards modelHazard ratioEnvironmental risk scoreLowest quartileIndividual metal concentrationsExposure to metalsUrinary metal concentrationsHazards modelMedian follow-upMonths of amenorrheaWomen's HealthAssociated with earlier natural menopauseEarly natural menopauseUrinary metalsNation Multi-Pollutant StudyBleeding episodesHormone therapyPremenopausal womenMedian age
2020
Urinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN)
Wang X, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Urinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN). Environmental Research 2020, 196: 110426. PMID: 33157106, PMCID: PMC8093324, DOI: 10.1016/j.envres.2020.110426.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthWomen's HealthExposure to cadmiumUrinary metal concentrationsUrinary molybdenumMetal concentrationsMetal exposureSOB-RUrinary metalsNation Multi-Pollutant StudyAssociated with favorable profilesStandard deviation increaseCadmiumLinear regression modelsAdverse adipokine profileMidlife womenLevels of sOB-RHMW adiponectinUrinary cesiumFollow-up visitHuman populationSoluble leptin receptorAdaptive elastic-netSOB-R levelsMetal