Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds. Journal Of Clinical Oncology 2013, 31: 431-431. DOI: 10.1200/jco.2013.31.4_suppl.431.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsInvestigate parent-of-origin effectsLynch syndrome familiesMMR mutation carriersLynch syndrome kindredGenetic anticipationHospital-based registryOffspring of affected mothersLS familiesLynch syndromePaired t-testRisk of diseaseSyndrome familiesMutation carriersInvestigate parentT-testDisease allelesAffected fatherStatistical significanceKindredMothersSeverity of diseaseFamily