Featured Publications
Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons
Clark-Boucher D, Zhou X, Du J, Liu Y, Needham B, Smith J, Mukherjee B. Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons. PLOS Genetics 2023, 19: e1011022. PMID: 37934796, PMCID: PMC10655967, DOI: 10.1371/journal.pgen.1011022.Peer-Reviewed Original ResearchConceptsBayesian Sparse Linear Mixed ModelMediation analysisHigh-dimensional mediation analysisMulti-ethnic cohortEpigenetic researchHealth outcomesHigh-dimensional DNA methylation dataLinear mixed modelsDNA methylation dataContinuous outcomesEvaluate DNA methylationDNA methylationMethylation dataDNAm dataMixed modelsDiverse simulationsSeamless implementationModern statistical methodsMediation effectR packageUnited StatesOutcomes
2024
Impact of pandemic-related worries on mental health in India from 2020 to 2022
Yang Y, Sun A, Zimmermann L, Mukherjee B. Impact of pandemic-related worries on mental health in India from 2020 to 2022. Npj Mental Health Research 2024, 3: 57. PMID: 39582077, PMCID: PMC11586416, DOI: 10.1038/s44184-024-00101-x.Peer-Reviewed Original ResearchMental healthCalendar timeSelf-reported symptoms of depressionMental health outcomesPandemic-related worriesSymptoms of depressionMental health trendsSelf-reported symptomsHealth outcomesPublic health crisisHealth trendsEffect modifiersImpact SurveyResidential statusSocial media platformsFinancial stressHealth crisisWorryHealthInteraction termsMedia platformsAnxietyDepressionSurvey dataCalendarCross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposure
2022
Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals
Fang Y, Fritsche L, Mukherjee B, Sen S, Richmond-Rakerd L. Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals. Biological Psychiatry 2022, 92: 923-931. PMID: 35965108, PMCID: PMC10712651, DOI: 10.1016/j.biopsych.2022.06.004.Peer-Reviewed Original ResearchConceptsPhenome-wide association studyPolygenic risk scoresMDD PRSHealth recordsRisk scoreAssociation studiesGenome-wide polygenic risk scoreAssociated with multiple medical conditionsMeasures of genetic riskMichigan Genomics InitiativePsychiatric traitsElectronic health recordsEuropean ancestry participantsMajor depressive disorderAssociated with tobacco use disorderTests of associationMultiple medical conditionsGenitourinary conditionsTobacco use disorderDisease-associated disabilityMolecular genetic toolsMolecular genetic discoveriesPsychiatric disease categoriesHealth outcomesSubstance-related disordersMaternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomes
2021
A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures
Boss J, Rix A, Chen Y, Narisetty N, Wu Z, Ferguson K, McElrath T, Meeker J, Mukherjee B. A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures. Environmetrics 2021, 32 PMID: 34899005, PMCID: PMC8664243, DOI: 10.1002/env.2698.Peer-Reviewed Original ResearchGroup least absolute shrinkageEnvironmental health studiesHealth outcomesHealth StudyLIFECODES birth cohortBirth cohortExposure interactionsPenalized regression methodsDose-response relationshipExposure mixturesComprehensive R Archive NetworkInteraction effectsInduce sparsityAdaptive weightsGroup lassoSelection operatorHeredity constraintLeast Absolute ShrinkageSelection frameworkNonlinear interaction effectsSample sizeVariable selectionJoint effectsCoefficient estimatesGroup structureExposure and risk factors for COVID-19 and the impact of staying home on Michigan residents
Wu K, Hornsby W, Klunder B, Krause A, Driscoll A, Kulka J, Bickett-Hickok R, Fellows A, Graham S, Kaleba E, Hayek S, Shi X, Sutton N, Douville N, Mukherjee B, Jamerson K, Brummett C, Willer C. Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents. PLOS ONE 2021, 16: e0246447. PMID: 33556117, PMCID: PMC7870003, DOI: 10.1371/journal.pone.0246447.Peer-Reviewed Original ResearchConceptsAfrican AmericansAnnual household income <Worsening health behaviorsLong-term health outcomesHousehold income <Low socioeconomic statusExposure to family membersHigher overall concernHigh riskExposure to familyHigh risk of contracting COVID-19Positive COVID-19 testLow-income groupsHealth behaviorsHealth outcomesRates of COVID-19 casesRental housingSocioeconomic statusClinical careRisk of contracting COVID-19COVID-19 preventionChronic diseasesInequality gapState of MichiganCOVID-19 cases
2020
Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes
Salerno S, Zhao Z, Sankar S, Salvatore M, Gu T, Fritsche L, Lee S, Lisabeth L, Valley T, Mukherjee B. Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes. Journal Of Internal Medicine 2020, 289: 726-737. PMID: 33253457, PMCID: PMC7753604, DOI: 10.1111/joim.13213.Peer-Reviewed Original ResearchConceptsAssociated with repeat testingFalse-negative rateNeighborhood poverty levelPre-existing type 2 diabetesSevere COVID-19-related outcomesDiagnostic testsPatient characteristicsPre-existing kidney diseaseBody mass indexICU-level careHealth outcomesCOVID-19-related outcomesCharacteristics of patientsCOVID-19 diagnostic testsType 2 diabetesMichigan MedicineMass indexCOVID-19Pain symptomsPatient agePoverty levelDownstream outcomesKidney diseaseRepeated testingLiver diseaseAssociations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's HealthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
2019
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Aung M, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals. Reproductive Toxicology 2019, 93: 43-53. PMID: 31881266, PMCID: PMC7138746, DOI: 10.1016/j.reprotox.2019.12.004.Peer-Reviewed Original ResearchConceptsIL-1BBayesian kernel machine regressionKernel machine regressionInterleukin-1bInterquartile range differenceCross-sectional studyAssociated with biomarkersReproductive health outcomesImmune signaling moleculesHealth outcomesLIFECODES birth cohortPregnant womenImmune perturbationsImmune biomarkersBirth cohortUrinary manganeseMachine regressionLinear regressionExposure analytesAssociationSignaling moleculesRegressionPair-wise associationsTrimesterPregnancyAssociation Between Life Purpose and Mortality Among US Adults Older Than 50 Years
Alimujiang A, Wiensch A, Boss J, Fleischer N, Mondul A, McLean K, Mukherjee B, Pearce C. Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years. JAMA Network Open 2019, 2: e194270. PMID: 31125099, PMCID: PMC6632139, DOI: 10.1001/jamanetworkopen.2019.4270.Peer-Reviewed Original ResearchConceptsHealth and Retirement StudyCause-specific mortalityAll-causeHealth outcomesUS adultsHealth and Retirement Study participantsCohort study of US adultsCause-specific mortality analysesInterview periodStudy of US adultsInfluence health outcomesAssociated with all-cause mortalityLife purposeCohort study sampleWeighted Cox proportional hazards modelsNational cohort studyPurpose in lifeQuality of lifeAll-cause mortalityCox proportional hazards modelsEnhance overall qualityAssociated with decreased mortalityProportional hazards modelRetirement StudyMortality associations
2018
Selection of nonlinear interactions by a forward stepwise algorithm: Application to identifying environmental chemical mixtures affecting health outcomes
Narisetty N, Mukherjee B, Chen Y, Gonzalez R, Meeker J. Selection of nonlinear interactions by a forward stepwise algorithm: Application to identifying environmental chemical mixtures affecting health outcomes. Statistics In Medicine 2018, 38: 1582-1600. PMID: 30586682, PMCID: PMC7134269, DOI: 10.1002/sim.8059.Peer-Reviewed Original ResearchAssociations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy
Ferguson K, Kamai E, Cantonwine D, Mukherjee B, Meeker J, McElrath T. Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy. American Journal Of Reproductive Immunology 2018, 80: e13017. PMID: 29984454, PMCID: PMC6160349, DOI: 10.1111/aji.13017.Peer-Reviewed Original ResearchConceptsAssociated with reduced fetal growthFetal growthAssociated with poorer childAdult health outcomesOxidative stress markersBirth cohort studyInterquartile rangeAssociated with head circumferenceRepeated-measures modelFetal weight z-scoreAssociated with fetal weightOxidative stressHealth outcomesStandard deviation decreaseWeight z-scoreStress markersSecondary analysisMaternal oxidative stressCohort studyZ-scoreFetal weightMaternal inflammationDeviation decreasePreterm birthHead circumferenceDistributed Lag Interaction Models with Two Pollutants
Chen Y, Mukherjee B, Berrocal V. Distributed Lag Interaction Models with Two Pollutants. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2018, 68: 79-97. PMID: 30636815, PMCID: PMC6328049, DOI: 10.1111/rssc.12297.Peer-Reviewed Original ResearchMean square errorEffects of air pollutionDistributed lag modelsAir pollution studiesHealth outcomesNational MorbidityBias-variance tradeoffEnvironmental epidemiologyAir pollutionPollution studiesPollutionLag effectMortality countsMain effectTensor productShrinkage methodShrinkage versionAverage performanceNatural waySimulation studyJoint effectsInteraction structureMortalityNMMAPSMorbidityUsing community health workers to refer pregnant women and young children to health care facilities in rural West Bengal, India: A prospective cohort study
Wagner A, Xia L, Ghosh A, Datta S, Pandey P, Santra S, Chattopadhyay S, Nandi U, Mazumder T, Joshi S, Pal J, Mukherjee B. Using community health workers to refer pregnant women and young children to health care facilities in rural West Bengal, India: A prospective cohort study. PLOS ONE 2018, 13: e0199607. PMID: 29928057, PMCID: PMC6013192, DOI: 10.1371/journal.pone.0199607.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChild, PreschoolCommunity Health WorkersDeveloping CountriesDevelopmental DisabilitiesFeasibility StudiesFemaleFollow-Up StudiesHumansIndiaInfantLongitudinal StudiesMaleMothersPatient Acceptance of Health CarePregnancyPregnancy ComplicationsProspective StudiesReferral and ConsultationRisk FactorsRural PopulationVulnerable PopulationsYoung AdultConceptsCommunity health workersCommunity health worker visitsHealth behaviorsMothers of young childrenHealth careHealth workersPregnant womenHealth of vulnerable populationsOverall health behaviorsPositive health outcomesPreventive health careRisk of pregnancy-related complicationsRural areasHealth care facilitiesEarly childhood developmental delaysMothers of childrenRural areas of IndiaYoung childrenChildhood developmental delayPregnancy-related complicationsHealth outcomesCare facilitiesMedical characteristicsRe-contactedCareAssociations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study
Aker A, Johns L, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment International 2018, 113: 341-349. PMID: 29366524, PMCID: PMC5866216, DOI: 10.1016/j.envint.2018.01.006.Peer-Reviewed Original ResearchConceptsThyroid hormonesAssociated with altered thyroid hormone levelsFetal health outcomesThyroid hormone levelsIQR increaseMultivariate regression analysisGestational ageMultivariate linear regression modelFetal neurodevelopmentPregnant womenFree thyroxinePotential biological mechanismsTime of exposureUrinary biomarkersCohort studyHormone levelsParaben biomarkersTotal triiodothyronineCase-control samplePregnancyBlood samplesTotal thyroxineHormone concentrationsHealth outcomesHormone
2017
Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis
Smith J, Zhao W, Wang X, Ratliff S, Mukherjee B, Kardia S, Liu Y, Roux A, Needham B. Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics 2017, 12: 662-673. PMID: 28678593, PMCID: PMC5687339, DOI: 10.1080/15592294.2017.1341026.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of AtherosclerosisSocioeconomic disadvantageIndividual-level socioeconomic factorsEtiology of health disparitiesAssociated with poor health outcomesPopulation-based sample of US adultsSocioeconomic factorsNeighborhood conditionsNeighborhood socioeconomic disadvantageSample of US adultsNeighborhood social environmentHigher socioeconomic disadvantagePoor health outcomesIndividual socioeconomic factorsPopulation-based sampleDimensions of neighborhood contextHealth disparitiesInfluence methylation levelsHealth outcomesUS adultsSocial environmentDisadvantaged neighborhoodsNeighborhood characteristics
2012
Principal interactions analysis for repeated measures data: application to gene–gene and gene–environment interactions
Mukherjee B, Ko Y, VanderWeele T, Roy A, Park S, Chen J. Principal interactions analysis for repeated measures data: application to gene–gene and gene–environment interactions. Statistics In Medicine 2012, 31: 2531-2551. PMID: 22415818, PMCID: PMC4046647, DOI: 10.1002/sim.5315.Peer-Reviewed Original ResearchConceptsGene-environment interactionsGene-geneLongitudinal cohort studyNormative Aging StudyHealth outcomesMain effect termsMeasured outcomesAging StudyOccupational historyEpistasis modelsEnvironmental exposuresMain effectLongitudinal natureLongitudinal dataResampling-based methodsCell meansClassification arrayQuantitative traitsInteraction analysisRobust classLeading eigenvaluesSimulation studyTime-varying effectsSubject-specificOutcomes