2012
Efficient designs of gene–environment interaction studies: implications of Hardy–Weinberg equilibrium and gene–environment independence
Chen J, Kang G, VanderWeele T, Zhang C, Mukherjee B. Efficient designs of gene–environment interaction studies: implications of Hardy–Weinberg equilibrium and gene–environment independence. Statistics In Medicine 2012, 31: 2516-2530. PMID: 22362617, PMCID: PMC3448495, DOI: 10.1002/sim.4460.Peer-Reviewed Original ResearchConceptsPresence of G-E interactionsG-E interactionsSubsample of casesGene-environmentHardy-Weinberg equilibriumG-E independenceGene-environment interaction studiesGene-environment independenceRandom subsampleGenetic susceptibility variantsCase-control sampleEnvironmental risk factorsSusceptibility variantsExternal control dataRisk factorsGenetic effectsWald statisticInteraction studiesSubsampleVariable EControl dataEnvironmental effectsIndependenceDataWald
2009
Shrinkage estimation for robust and efficient screening of single‐SNP association from case‐control genome‐wide association studies
Luo S, Mukherjee B, Chen J, Chatterjee N. Shrinkage estimation for robust and efficient screening of single‐SNP association from case‐control genome‐wide association studies. Genetic Epidemiology 2009, 33: 740-750. PMID: 19434716, PMCID: PMC3103068, DOI: 10.1002/gepi.20428.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesComputational BiologyComputer SimulationData Interpretation, StatisticalFalse Positive ReactionsGenetic MarkersGenomeGenome, HumanGenome-Wide Association StudyGenotypeHumansLikelihood FunctionsModels, StatisticalPolymorphism, Single NucleotideReproducibility of ResultsConceptsHardy-Weinberg equilibriumAssociation TestPopulation-based case-control designGenome-wide association scanGenome-wide association studiesSingle-SNP associationsCase-control designCase-control studyAssociation scansAssociation studiesGenetic markersSusceptibility SNPsRecessive effectUnderlying populationAssociationFalse-positive resultsEfficient screeningSNPsRare diseaseShrinkage estimatorsSimulation studyStudyTestTwo-degrees-of-freedomPopulation
2008
Inference of the Haplotype Effect in a Matched Case-Control Study Using Unphased Genotype Data
Sinha S, Gruber S, Mukherjee B, Rennert G. Inference of the Haplotype Effect in a Matched Case-Control Study Using Unphased Genotype Data. The International Journal Of Biostatistics 2008, 4: article 6. PMID: 20231916, PMCID: PMC2835450, DOI: 10.2202/1557-4679.1079.Peer-Reviewed Original ResearchConceptsCase-control studyUnphased genotype dataHardy-Weinberg equilibriumLocus-specific genotype dataGenotype dataBeta-Carotene Cancer Prevention StudyCancer Prevention StudyCase-control study designStudy of breast cancer patientsMatched case-control studyCase-control designPhasing of haplotypesDisease risk modelsBreast cancer patientsPrevention StudyHaplotype effectsStudy designGametic phasePolymorphic lociHaplotype frequenciesCancer patientsLociConditional likelihood approachAssociationHaplotypes