2024
Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study
Siwakoti R, Park S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study. Chemosphere 2024, 360: 142363. PMID: 38768789, PMCID: PMC11487489, DOI: 10.1016/j.chemosphere.2024.142363.Peer-Reviewed Original ResearchFetal sexMaternal raceEffect modificationOS biomarkersOxidative stressPre-pregnancy BMIAdverse pregnancy outcomesNo significant effect modificationMaternal oxidative stressPlasma PFASsSignificant effect modificationInterquartile range increasePositive associationExposure to OSPre-pregnancyPregnancy outcomesMaternal ageMultivariate linear regressionSex-specific effectsLinear mixed-effects modelsPotential confoundersInsurance statusRange increaseEndocrine functionEducation levelAssociations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico
Kim C, Cathey A, Park S, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico. The Science Of The Total Environment 2024, 928: 172295. PMID: 38588744, DOI: 10.1016/j.scitotenv.2024.172295.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesSex-specific associationsBirth outcomesBlood metal concentrationsMetal concentrationsPregnant womenInfant sexEicosanoid profileMetal exposurePlasma eicosanoidsWeeks of pregnancyDecreased concentrations of CdConcentrations of CdConcentrations of CuEffect modificationRegulating inflammatory responsesBirth cohortAssessed associationsAssociated with increased concentrationsPregnancy outcomesFemale fetusesEffect sizeInflammatory activitySignificant associationInflammatory response
2023
Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008
Siwakoti R, Cathey A, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008. Environmental Research 2023, 237: 116967. PMID: 37634691, PMCID: PMC10913455, DOI: 10.1016/j.envres.2023.116967.Peer-Reviewed Original ResearchConceptsLarge-for-gestational agePreterm birth subtypesBayesian kernel machine regressionSize-for-gestational ageSmall-for-gestational agePreterm birthFetal sexPregnancy outcomesSex-specific estimatesIncreased risk of adverse pregnancy outcomesInterquartile range increaseRisk of adverse pregnancy outcomesBayesian kernel machine regression analysisEarly pregnancy samplesAdverse pregnancy outcomesCase-control studyPrenatal PFAS exposureAssociations of polyfluoroalkyl substancesBW z-scoreEffects of polyfluoroalkyl substancesKernel machine regressionEffect modificationEffects of prenatal exposureRange increaseStratified analysisPhthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncidence of diabetesWomen's HealthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidence
2022
Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes
Kalesnikava V, Clarke P, Mukherjee B, Sen S, Mezuk B. Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes. Psychosomatic Medicine 2022, 84: 813-821. PMID: 35980779, DOI: 10.1097/psy.0000000000001112.Peer-Reviewed Original ResearchConceptsDomain-specific stressMeasures of psychosocial stressTrier Social Stress TestAssociated with cortisol recoveryHypothalamic-pituitary-adrenal axis reactivityPsychosocial stressPerceived stressEvidence of effect modificationCortisol responseHigh-SES neighborhoodsHigher perceived stressPsychosocial stress measuresSocioeconomically diverse cohortCortisol recoveryRisk of diabetesAssociated with cortisol responseNeighborhood SESHealth disparitiesEffect modificationNeurobiological stress responseSocioeconomic statusSocial Stress TestSelf-report measuresType 2 diabetesSalivary cortisol responseRace-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 303: 119164. PMID: 35306088, PMCID: PMC9883839, DOI: 10.1016/j.envpol.2022.119164.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthBayesian kernel machine regressionWomen's HealthLeptin levelsBlack womenAssociated with lower leptinAssociated with favorable profilesAsian womenSoluble leptin receptorRacial differencesRace-specific associationsUrinary phenolCross-sectional associationsNo significant associationObesity-related metabolic diseasesLog-transformed levelsSOB-RKernel machine regressionSerum adipokinesMetabolic disease burdenEffect modificationNation Multi-Pollutant StudyLow leptinLeptin receptorLinear regression models
2016
Classification and Clustering Methods for Multiple Environmental Factors in Gene–Environment Interaction
Ko Y, Mukherjee B, Smith J, Kardia S, Allison M, Roux A. Classification and Clustering Methods for Multiple Environmental Factors in Gene–Environment Interaction. Epidemiology 2016, 27: 870-878. PMID: 27479650, PMCID: PMC5039086, DOI: 10.1097/ede.0000000000000548.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtherosclerosisBayes TheoremCluster AnalysisData Interpretation, StatisticalEnvironmental ExposureEpidemiologic Research DesignFemaleFollow-Up StudiesGene-Environment InteractionGenetic Predisposition to DiseaseHumansMiddle AgedModels, StatisticalRegression AnalysisRisk FactorsConceptsMultiple environmental exposuresGene-environment interactionsG x EEnvironmental exposuresMultiethnic Study of AtherosclerosisStudy of AtherosclerosisGene-environmentEffect modificationMultiethnic StudyEnvironmental factorsExposure subgroupsEnvironmental exposure profilesMain effectExposure profilesE studyEfficient analysis strategyE analysisMultiple environmental factorsSubgroupsAnalysis strategyFactorsExposureProduct terms
2014
Latent variable models for gene–environment interactions in longitudinal studies with multiple correlated exposures
Tao Y, Sánchez B, Mukherjee B. Latent variable models for gene–environment interactions in longitudinal studies with multiple correlated exposures. Statistics In Medicine 2014, 34: 1227-1241. PMID: 25545894, PMCID: PMC4355187, DOI: 10.1002/sim.6401.Peer-Reviewed Original ResearchMeSH KeywordsBiostatisticsChild, PreschoolComputer SimulationEnvironmental ExposureFemaleGene-Environment InteractionHemochromatosis ProteinHistocompatibility Antigens Class IHumansInfantInfant, NewbornLead PoisoningLongitudinal StudiesMembrane ProteinsMexicoModels, GeneticModels, StatisticalPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsConceptsGene-environment interactionsOutcome measuresCohort studyHealth effects of environmental exposuresEnvironmental exposuresInvestigate health effectsGene-environment associationsEffects of environmental exposuresEarly life exposuresLV frameworkG x E effectsMultivariate exposuresGenotyped single nucleotide polymorphismsEffect modificationShrinkage estimatorsLife exposureExposure measurementsSingle nucleotide polymorphismsData-adaptive wayMultiple testingOutcome dataLongitudinal studyLongitudinal natureGenetic factorsNucleotide polymorphisms
2008
Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study
Lampe B, Park S, Robins T, Mukherjee B, Litonjua A, Amarasiriwardena C, Weisskopf M, Sparrow D, Hu H. Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study. Environmental Health Perspectives 2008, 116: 1226-1230. PMID: 18795167, PMCID: PMC2535626, DOI: 10.1289/ehp.11265.Peer-Reviewed Original ResearchConceptsSmoking statusCommunity-based study of agingAssessed effect modificationForced vital capacityPulmonary functionCommunity-based studyAssociated with forced expiratory volumeStudy of AgingFEV(1)/FVC ratioCadmium exposureUrinary cadmiumNormative Aging StudyEffect modificationEnvironmental cadmium exposureLevels of cadmium exposureAssociated with reduced pulmonary functionTests of pulmonary functionMixed-effects modelsAging StudyChronic cadmium exposureSmokingCadmium body burdenForced expiratory volumeCigarette smokingLog unit increase