2024
Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study
Jang D, Dou J, Koubek E, Teener S, Zhou L, Bakulski K, Mukherjee B, Batterman S, Feldman E, Goutman S. Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study. Journal Of Neurology Neurosurgery & Psychiatry 2024, jnnp-2024-333978. PMID: 39107037, DOI: 10.1136/jnnp-2024-333978.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosis riskEnvironmental risk scoreAssociated with ALS riskALS riskGenetic riskRisk scorePolygenic risk scoresSelf-reported exposureGenome-wide association studiesStudy investigated associationsCase-control studySingle-nucleotide polymorphismsAssociation studiesExposure mixturesControl participantsExposure sourcesRiskParticipantsAmyotrophic lateral sclerosisSurvival modelsScoresAssociationEnvironmental factorsUrine metalsUrine samplesResidential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study
Goutman S, Boss J, Jang D, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman E, Batterman S. Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2024, 25: 543-553. PMID: 38557405, PMCID: PMC11269018, DOI: 10.1080/21678421.2024.2336110.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosis riskAssociated with ALS riskALS riskCase-only analysisResidential settingsControl participantsCox proportional hazards modelsLogistic regression modelsCase-control studyMultinomial logistic regressionMultiple testing correctionProportional hazards modelLatent profile analysisResidential exposureExposure variablesPolytomous outcomesExposure associationsDecrease disease burdenALS susceptibilityLogistic regressionDisease burdenTesting correctionHazards modelRisk factorsRegression modelsAvocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study
Goutman S, Boss J, Jang D, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman E, Batterman S. Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. Journal Of The Neurological Sciences 2024, 457: 122899. PMID: 38278093, PMCID: PMC11060628, DOI: 10.1016/j.jns.2024.122899.Peer-Reviewed Original ResearchConceptsALS riskLower educational attainmentAssociated with ALS riskCase-control studyExercise 5Onset ageSelf-completionExposure variablesYard workExposure associationsRecreational danceIdentified exposureExerciseEducational attainmentAL burdenEnvironmental exposuresParticipantsAL factorPersonal participationAvocational exposureRiskExposomeHobbiesALS onsetComparison correction
2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality rate