2024
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank
Jin W, Boss J, Bakulski K, Goutman S, Feldman E, Fritsche L, Mukherjee B. Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. Journal Of Neurology 2024, 271: 6923-6934. PMID: 39249108, DOI: 10.1007/s00415-024-12644-2.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scorePre-existing conditionsPhenome-wide association studyControls of European descentPhenotype risk scoreUK Biobank dataAmyotrophic lateral sclerosis riskRisk score distributionIncreased ALS riskInfluence of environmental exposuresExposure-related factorsCombined risk scoreUK BiobankAmyotrophic lateral sclerosisBaseline demographic covariatesBiobank dataPRS-CSALS riskAmyotrophic lateral sclerosis diagnosisDiagnosis 1Demographic covariatesAssociation studiesEuropean descentMethodsUtilizing dataMultiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study
Jang D, Dou J, Koubek E, Teener S, Zhou L, Bakulski K, Mukherjee B, Batterman S, Feldman E, Goutman S. Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study. Journal Of Neurology Neurosurgery & Psychiatry 2024, jnnp-2024-333978. PMID: 39107037, DOI: 10.1136/jnnp-2024-333978.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosis riskEnvironmental risk scoreAssociated with ALS riskALS riskGenetic riskRisk scorePolygenic risk scoresSelf-reported exposureGenome-wide association studiesStudy investigated associationsCase-control studySingle-nucleotide polymorphismsAssociation studiesExposure mixturesControl participantsExposure sourcesRiskParticipantsAmyotrophic lateral sclerosisSurvival modelsScoresAssociationEnvironmental factorsUrine metalsUrine samplesResidential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study
Goutman S, Boss J, Jang D, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman E, Batterman S. Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2024, 25: 543-553. PMID: 38557405, PMCID: PMC11269018, DOI: 10.1080/21678421.2024.2336110.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosis riskAssociated with ALS riskALS riskCase-only analysisResidential settingsControl participantsCox proportional hazards modelsLogistic regression modelsCase-control studyMultinomial logistic regressionMultiple testing correctionProportional hazards modelLatent profile analysisResidential exposureExposure variablesPolytomous outcomesExposure associationsDecrease disease burdenALS susceptibilityLogistic regressionDisease burdenTesting correctionHazards modelRisk factorsRegression models
2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality rate