2024
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank
Jin W, Boss J, Bakulski K, Goutman S, Feldman E, Fritsche L, Mukherjee B. Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. Journal Of Neurology 2024, 271: 6923-6934. PMID: 39249108, DOI: 10.1007/s00415-024-12644-2.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scorePre-existing conditionsPhenome-wide association studyControls of European descentPhenotype risk scoreUK Biobank dataAmyotrophic lateral sclerosis riskRisk score distributionIncreased ALS riskInfluence of environmental exposuresExposure-related factorsCombined risk scoreUK BiobankAmyotrophic lateral sclerosisBaseline demographic covariatesBiobank dataPRS-CSALS riskAmyotrophic lateral sclerosis diagnosisDiagnosis 1Demographic covariatesAssociation studiesEuropean descentMethodsUtilizing data
2022
Associations of self-reported occupational exposures and settings to ALS: a case–control study
Goutman S, Boss J, Godwin C, Mukherjee B, Feldman E, Batterman S. Associations of self-reported occupational exposures and settings to ALS: a case–control study. International Archives Of Occupational And Environmental Health 2022, 95: 1567-1586. PMID: 35593931, PMCID: PMC9424174, DOI: 10.1007/s00420-022-01874-4.Peer-Reviewed Original ResearchConceptsStandard Occupational ClassificationStandard Occupational Classification codesExposure to particulate matterProductive occupationsALS riskSelf-reported occupational exposureHigher risk of amyotrophic lateral sclerosisOccupational exposureHigher ALS riskRisk of amyotrophic lateral sclerosisRisk factor modificationOccupational exposure to particulate matterExposure surveyIncreased ALS riskCase-control studyMaintenance occupationsGrounds cleaningFactor modificationExposure scoreTargeted screeningAmyotrophic lateral sclerosis diagnosisRepair occupationsAdaptive elastic net modelOccupational classificationProgressive neurological disease