2006
p38 Mitogen-Activated Protein Kinase Activation in Endothelial Cell Is Implicated in Cell Alignment and Elongation Induced by Fluid Shear Stress
Kadohama T, Akasaka N, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. p38 Mitogen-Activated Protein Kinase Activation in Endothelial Cell Is Implicated in Cell Alignment and Elongation Induced by Fluid Shear Stress. Endothelium 2006, 13: 43-50. PMID: 16885066, DOI: 10.1080/10623320600660219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAtherosclerosisBlood PressureBlood VesselsCattleCell PolarityCell ShapeCells, CulturedDose-Response Relationship, DrugEndothelial CellsEnzyme ActivationEnzyme InhibitorsHemodynamicsMAP Kinase Signaling SystemP38 Mitogen-Activated Protein KinasesPhosphorylationRegional Blood FlowStress, MechanicalTime FactorsConceptsStatic endothelial cellsFluid shear stressP38 MAPKP38 Mitogen-Activated Protein Kinase ActivationMitogen-Activated Protein Kinase ActivationEndothelial cellsProtein kinase activationP38 MAPK inhibitor SB-203580Inhibitor SB 203580Cell alignmentProtein kinaseBovine aortic endothelial cellsLaminar shear stressKinase activationSB 203580P38 mitogenCultured bovine aortic endothelial cellsEC elongationAortic endothelial cellsMAPKCellsElongationActivationMorphometric analysisKinase
2001
The Integrin-Mediated Cyclic Strain-Induced Signaling Pathway in Vascular Endothelial Cells
Frangos S, Knox R, Yano Y, Chen E, Di Luozzo G, Chen A, Sumpio B. The Integrin-Mediated Cyclic Strain-Induced Signaling Pathway in Vascular Endothelial Cells. Endothelium 2001, 8: 1-10. PMID: 11409847, DOI: 10.3109/10623320109063153.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase (MAPK) familyCytoplasmic protein kinaseProtein kinase familySignal transduction pathwaysFocal adhesion kinaseExtracellular matrix receptorsProcess of phosphorylationEndothelial cellsKinase familySignal transductionTranscription factorsAdhesion kinaseProtein kinaseTransduction pathwaysMatrix receptorsGene expressionTyrosine residuesSignaling pathwaysCyclic circumferential strainVascular endothelial cellsPathwayKinaseIntegrinsHemodynamic forcesVasculature results
1994
Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications.
Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications. Hepatogastroenterology 1994, 41: 573-7. PMID: 7721248.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHepatic VeinsHumansHypertension, PortalLiver Cirrhosis, AlcoholicMaleMonitoring, IntraoperativePortal PressureProspective StudiesRadiographyRegional Blood FlowRetrospective StudiesSplenic VeinSplenomegalySplenorenal Shunt, SurgicalConceptsCirrhotic patientsPortal pressurePortal hypertensionSplenic embolizationVariceal bleedingHemodynamic basisSpleen sizeDistal splenorenal shuntPortal hypertensive patientsSplenic venous flowVariceal bleedersDefinitive therapyHypertensive patientsSplenorenal shuntSplenic enlargementSplenic veinVenous flowHemodynamic significancePatientsSplenomegalySplenic inflowTreatment implicationsHypertensionBleedingSplenectomy
1993
Defecation Syncope Secondary to Functional Inferior Vena Caval Obstruction During a Valsalva Maneuver
Brophy C, Evans L, Sumpio B. Defecation Syncope Secondary to Functional Inferior Vena Caval Obstruction During a Valsalva Maneuver. Annals Of Vascular Surgery 1993, 7: 374-377. PMID: 8268080, DOI: 10.1007/bf02002893.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureDefecationFemaleHumansSyncopeValsalva ManeuverVascular DiseasesVena Cava, InferiorConceptsValsalva maneuverDefecation syncopeInferior vena cava obstructionInferior vena caval obstructionPreoperative hemodynamic assessmentVena caval obstructionEffective surgical approachVena cava obstructionContinuous hemodynamic monitoringIVC obstructionCava obstructionCaval obstructionBlood pressureFunctional obstructionHemodynamic assessmentHemodynamic monitoringDiaphragmatic hiatusSurgical approachTransesophageal ultrasonographyFunctional disordersIVC patencyIntraoperative approachSurgical mobilizationObstructionExtensive mobilizationCaptopril renal scintigraphy: A new standard for predicting outcome after renal revascularization
Meier G, Sumpio B, Setaro J, Black H, Gusberg R. Captopril renal scintigraphy: A new standard for predicting outcome after renal revascularization. Journal Of Vascular Surgery 1993, 17: 280-287. PMID: 8433423, DOI: 10.1016/0741-5214(93)90413-g.Peer-Reviewed Original ResearchConceptsCaptopril renal scintigraphyCaptopril-induced changesRenal revascularizationHypertension responseBlood pressureAmerican Heart Association criteriaDose of captoprilGlomerular filtration rateCessation of administrationNuclear medicine techniquesCaptopril administrationStandard renogramRenovascular diseaseBalloon angioplastyVascular toneRenal scintigraphyFiltration rateBaseline scanRevascularizationStudy groupAssociation criteriaPatientsEnzyme inhibitorsMedicine techniquesRenogram