2015
Operative Management of Hilar Renal Artery Aneurysm in a Pregnant Patient
Schulte W, Rodriguez-Davalos M, Lujic M, Schlosser F, Sumpio B. Operative Management of Hilar Renal Artery Aneurysm in a Pregnant Patient. Annals Of Vascular Diseases 2015, 8: 242-245. PMID: 26421074, PMCID: PMC4575337, DOI: 10.3400/avd.cr.15-00026.Peer-Reviewed Original ResearchRenal artery aneurysmArtery aneurysmHilar renal artery aneurysmsRight renal artery aneurysmCurrent pathophysiologic mechanismsSevere retroperitoneal hemorrhageRare clinical entityCurrent treatment modalitiesPregnant patientsRetroperitoneal hemorrhagePathophysiologic mechanismsPrimary repairClinical entityOperative managementSurgical approachSpontaneous ruptureTreatment modalitiesPostpartum periodAneurysmsComplicationsHemorrhagePatientsSymptomsKidneyIncidence
2003
Abdominal aortic aneurysm in association with a congenital pelvic horseshoe kidney: sentinel report and technical consideration
Renzulli JF, Borromeo JR, Barkhordarian S, Sumpio BE. Abdominal aortic aneurysm in association with a congenital pelvic horseshoe kidney: sentinel report and technical consideration. Vascular Medicine 2003, 8: 197-199. PMID: 14989561, DOI: 10.1191/1358863x03vm495cr.Peer-Reviewed Original Research
2000
Diabetic Vascular Disease: Biochemical and Molecular Perspectives
Kamal K, Chang R, Sumpio B. Diabetic Vascular Disease: Biochemical and Molecular Perspectives. 2000, 817-834. DOI: 10.1007/978-1-4612-1190-7_68.Peer-Reviewed Original ResearchDiabetes mellitusChronic complicationsMajor chronic complicationsEnd-organ damageCharacteristic pathological featuresDiscovery of insulinDiabetic patientsDiabetic angiopathyMetabolic abnormalitiesChronic hyperglycemiaPathological featuresVascular diseaseMellitusNatural historyComplicationsDiabetesPatientsAngiopathyMorbidityHyperglycemiaNerveKidneyMortalityAbnormalitiesInsulin
1991
Amelioration of renal ischemic injury by phosphocreatine
Rodriguez R, Stepke M, Maitz S, Cuono C, Sumpio B. Amelioration of renal ischemic injury by phosphocreatine. Journal Of Surgical Research 1991, 51: 271-274. PMID: 1921364, DOI: 10.1016/0022-4804(91)90106-v.Peer-Reviewed Original ResearchConceptsRenal ischemic injuryInitial ischemic insultPerfusion of kidneysKrebs-bicarbonate solutionMin of normothermicMM phosphocreatineRenal functionIschemic injuryKidney functionIschemic insultRenal arteryVivo ischemiaWarm ischemiaKrebs solutionKidneyPhosphocreatineAddition of phosphocreatineIschemiaSignificant improvementRegeneration of ATPGFRArteryNormothermicUreterInjury
1989
The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney
Sumpio B, Upchurch G, Johnson G. The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney. Journal Of Surgical Research 1989, 46: 4-8. PMID: 2915534, DOI: 10.1016/0022-4804(89)90174-1.Peer-Reviewed Original ResearchConceptsRenal functionMean renal arterial pressureRat kidneyKrebs-HCO3 bufferRenal arterial pressureReabsorption of sodiumArterial pressureUrine flowOrgan functionClinical interestHCO3- bufferPerfusate solutionHematocritBlood rheologyFunctional parametersPerfusate viscosityRBC deformabilityKidneyPerfusateDegrees CRBCsDrag-reducing agentsGFRCreatinineAgents
1987
Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia
Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. American Journal Of Physiology 1987, 252: r388-r393. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.r388.Peer-Reviewed Original ResearchConceptsRenal functionATP-MgCl2Warm ischemiaATP-MgCl2 treatmentKrebs-HCO3 bufferMM ATP-MgCl2Comparison of effectsNormothermic ischemiaTransient improvementIschemiaSalutary effectsControl valuesUrine samplesFunctional parametersKidneyMajor breakdown productAdenosineTreatmentBreakdown productsMmHgPerfusateMinAdministration
1986
Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney
Sumpio B, Hull M, Bauer A, Chaudry I. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-308. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.Peer-Reviewed Original ResearchConceptsATP-MgCl2 administrationColloid oncotic pressureIntracellular ATPATP-MgCl2Exogenous administrationIntracellular ATP levelsRat kidneyOncotic pressureAdministrationTotal intracellular ATPPerfusate solutionKidneyIntracellular accumulationATP levelsAdenine nucleotidesSignificant accumulationATPPerfusate
1985
Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia
Sumpio B, Chaudry I, Clemens M, Baue A. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. AJP Regulatory Integrative And Comparative Physiology 1985, 248: r752-r752. DOI: 10.1152/ajpregu.1985.248.6.r752-r.Peer-Reviewed Original ResearchReduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 429-437. PMID: 3872963, DOI: 10.1016/0022-4804(85)90058-7.Peer-Reviewed Original ResearchConceptsAcute renal failureATP-MgCl2Hr of perfusionCis-DiamminedichloroplatinumNephrotoxic effectsReabsorptive capacityCDDP treatmentRat kidneyATP-MgCl2 treatmentIsolated rat kidneyDrug-induced nephrotoxicityDirect nephrotoxic effectNew therapeutic modalitiesProximal tubule cellsCancer chemotherapeutic agentsCDDP therapyRenal failureMarked diuresisProtein reabsorptionTherapeutic modalitiesTubule cellsChemotherapeutic agentsMicrograms/KidneyMarked inhibition
1984
Renal hydrolysis of absorbed protein: influence of load and lysosomal pH
Camargo MJ, Sumpio BE, Maack T. Renal hydrolysis of absorbed protein: influence of load and lysosomal pH. American Journal Of Physiology 1984, 247: f656-f664. PMID: 6093557, DOI: 10.1152/ajprenal.1984.247.4.f656.Peer-Reviewed Original ResearchConceptsNormal filtered loadEfflux of radioactivityRenal tubular cellsEffect of alkalinizationProtein absorption dropletsRenal catabolismNormal lysosomal functionLysosomotropic weak basesFiltered loadTubular cellsKidney 1Abnormal depositionRat kidneyKidneyAbsorption dropletsSaturable processIntracellular hydrolysisSaturable functionLysosomal functionPerfusateLysosomal pHLow uptake rateSephadex chromatographyReversible mannerHalf times
1982
Kinetics, competition, and selectivity of tubular absorption of proteins
Sumpio BE, Maack T. Kinetics, competition, and selectivity of tubular absorption of proteins. American Journal Of Physiology 1982, 243: f379-f392. PMID: 7124951, DOI: 10.1152/ajprenal.1982.243.4.f379.Peer-Reviewed Original ResearchConceptsBeta 2MTubular absorptionHuman growth hormoneLow perfusate calcium concentrationsPerfusate calcium concentrationMorphologic damageTubular epitheliumProximal tubulesGrowth hormoneRat kidneyCationic proteinCalcium concentrationSaturable processSaturating loadSelective effectLuminal wallLow apparent affinityTubulesImportant determinantReversible mannerApparent affinityMicrovilliProteinKidney