2017
Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow
Shalaby SY, Chitragari G, Sumpio BJ, Sumpio BE. Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow. International Journal Of Angiology 2017, 26: 109-115. PMID: 28566937, PMCID: PMC5446257, DOI: 10.1055/s-0037-1599057.Peer-Reviewed Original ResearchExtracellular signal-regulated kinase 5Pathogenesis of atherosclerosisExposure of HUVECERK5 activationVascular dysfunctionPattern of activationFro flowVascular remodelingConfluent HUVECsHours of exposurePhospho-ERK5Endothelial integrityActivation of ERK5Kinase 5Sustained activationEnd of experimentationERK5 phosphorylationHUVECActivationHoursExposureTransient phosphorylationCell lysatesDisturbed flow conditionsParallel plate flow chamber
2012
169
Oda S, Hirasawa H, Sumpio B. 169. Critical Care Medicine 2012, 40: 1-328. DOI: 10.1097/01.ccm.0000424389.66537.91.Peer-Reviewed Original ResearchTF RNA expressionHigh TF expressionTF expressionTissue factorEndothelial cellsChemical stimulationRNA expressionExcessive inflammatory reactionReal-time RT-PCRLaminar flowVascular endothelial cellsQuantitative real-time RT-PCRHemodynamic stabilizationIntravascular activationIntravascular thrombosisFro flowInflammatory reactionExtrinsic coagulationTumor growth