2019
New Twists and Turns in Bacterial Locomotion and Signal Transduction
Watts KJ, Vaknin A, Fuqua C, Kazmierczak BI. New Twists and Turns in Bacterial Locomotion and Signal Transduction. Journal Of Bacteriology 2019, 201: 10.1128/jb.00439-19. PMID: 31358610, PMCID: PMC6755736, DOI: 10.1128/jb.00439-19.Peer-Reviewed Original ResearchConceptsSignal transductionTwo-component signal transduction pathwayTwo-component signal transduction systemBacterial locomotionContribution of motilityCryo-electron tomographySignal transduction systemSystems biology approachSignal transduction pathwaysIndividual bacterial cellsMulticellular organismsProkaryotic organismsBiology approachChemosensory receptorsFlagellar motorPathogenic interactionsTransduction pathwaysTransduction systemIndividual proteinsSensing pathwaysProtein labelingBehavior of thousandsComplex ecosystemsProtein spaceLiving cells
2015
Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection
Jhingran A, Kasahara S, Shepardson KM, Junecko BA, Heung LJ, Kumasaka DK, Knoblaugh SE, Lin X, Kazmierczak BI, Reinhart TA, Cramer RA, Hohl TM. Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection. PLOS Pathogens 2015, 11: e1004589. PMID: 25621893, PMCID: PMC4306481, DOI: 10.1371/journal.ppat.1004589.Peer-Reviewed Original ResearchConceptsRespiratory fungal infectionsDistinct signal transduction pathwaysSignal transduction pathwaysNeutrophil recruitmentChemokine inductionGenetic deletionFungal infectionsFungal clearanceCellular compartmentsTransduction pathwaysC-type lectinProtein triggersLung epithelial cellsNeutrophil-dependent host defenseInterleukin-1 receptorReceptor signalsConidial uptakeLung neutrophil recruitmentLung-infiltrating neutrophilsNeutrophil chemokines CXCL1Sequential rolesMyD88-deficient miceHematopoietic compartmentProtein knockout miceMajor cellular source