2021
Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease
Weerackoon N, Gunawardhana KL, Mani A. Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease. Journal Of Cellular Signaling 2021, 2: 52-62. PMID: 33969358, PMCID: PMC8098721, DOI: 10.33696/signaling.2.035.Peer-Reviewed Original ResearchCoronary artery diseaseVascular smooth muscle cellsLow-density lipoproteinPlaque erosionDisease processWnt pathwayAdult cardiovascular diseaseDistinct disease processesSmooth muscle proliferationType 2 diabetesCause of deathMajor congenital defectsModified low-density lipoproteinSmooth muscle cellsWnt/β-catenin signalingCoronary artery healthCanonical Wnt/β-catenin signalingAggregation of monocytesActivation of WntΒ-catenin signalingArtery diseaseEndothelial cell defectsEndothelial dysfunctionWnt/CaVascular inflammation
2018
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome
Abou Ziki M, Mani A. The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. Nutrition Research 2018, 70: 18-25. PMID: 30049588, PMCID: PMC6320319, DOI: 10.1016/j.nutres.2018.06.009.Peer-Reviewed Original ResearchConceptsMetabolic syndromeLow density lipoprotein clearanceVascular smooth muscle proliferationEnd-organ complicationsCanonical WntSmooth muscle proliferationLow-density lipoproteinDe novo lipogenesisInsulin receptor expressionTranscription factor 7Growth factor βRas homolog gene family member AExtracellular matrix depositionCardiometabolic abnormalitiesLiver inflammationFamily member AInsulin resistanceLipoprotein clearanceLiver fatHepatic fibrosisSevere manifestationsLDL receptor-related protein 6Receptor expressionCardiovascular diseaseMuscle proliferation