2023
EARLY ADVERSITY CAUSES SEX-SPECIFIC DEFICITS IN ENTORHINAL-DORSAL HIPPOCAMPUS CONNECTIVITY AND CONTEXTUAL FEAR CONDITIONING IN ADOLESCENT MICE
Islam R, Arefin T, White J, Polis B, Ahmed S, Liu X, Zhang J, Kaffman A. EARLY ADVERSITY CAUSES SEX-SPECIFIC DEFICITS IN ENTORHINAL-DORSAL HIPPOCAMPUS CONNECTIVITY AND CONTEXTUAL FEAR CONDITIONING IN ADOLESCENT MICE. IBRO Neuroscience Reports 2023, 15: s103-s104. DOI: 10.1016/j.ibneur.2023.08.089.Peer-Reviewed Original Research
2022
Early life stress impairs synaptic pruning in the developing hippocampus
Dayananda KK, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Early life stress impairs synaptic pruning in the developing hippocampus. Brain Behavior And Immunity 2022, 107: 16-31. PMID: 36174883, PMCID: PMC10497209, DOI: 10.1016/j.bbi.2022.09.014.Peer-Reviewed Original ResearchConceptsSynaptic pruningMicroglial ramificationHippocampal functionAbnormal hippocampal functionCA1 pyramidal neuronsExpression of TREM2Increased spine densityRamification of microgliaEarly life adversityNormal hippocampal functionSynaptic engulfmentClinical outcomesPyramidal neuronsSpine densityFemale miceHippocampal stimulationSevere formHippocampal developmentPhagocytic activitySevere impairmentEx vivoLife adversityThird weekEarly adversityMice
2021
Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging
Arefin TM, Lee CH, White JD, Zhang J, Kaffman A. Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging. Bio-protocol 2021, 11: e4221. PMID: 34909442, PMCID: PMC8635841, DOI: 10.21769/bioprotoc.4221.Peer-Reviewed Original ResearchEarly life stressMagnetic resonance imagingMouse brainDiffusion magnetic resonance imagingMouse modelResonance imagingWhole-brain voxel-based analysisVoxel-based analysisClinical trialsPostnatal stressPreclinical studiesNeurological conditionsAdult miceEntire mouse brainStructural abnormalitiesBrain regionsMouse strainsBrain connectivityBrainLife stressTranslational utilityStructural connectivityRodentsMiceTranslational work
2020
Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents
Wang D, Levine JLS, Avila-Quintero V, Bloch M, Kaffman A. Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents. Translational Psychiatry 2020, 10: 174. PMID: 32483128, PMCID: PMC7264128, DOI: 10.1038/s41398-020-0856-0.Peer-Reviewed Original ResearchConceptsOpen field testEarly life stressSystematic reviewEffects of MSEffects of ELSAnxiety-like behaviorDefensive behaviorAnxiogenic effectsMaternal separationRodent modelsRatsEarly adversityMiceAbility of MSLife stressLack of standardizationChildhood maltreatmentRodentsExploratory behaviorEffect sizeInconsistent resultsELS modelImportant differencesReviewMS protocol
2018
Amygdala hyper-connectivity in a mouse model of unpredictable early life stress
Johnson FK, Delpech JC, Thompson GJ, Wei L, Hao J, Herman P, Hyder F, Kaffman A. Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Translational Psychiatry 2018, 8: 49. PMID: 29463821, PMCID: PMC5820270, DOI: 10.1038/s41398-018-0092-z.Peer-Reviewed Original ResearchConceptsEarly life stressAdult male miceAnxiety-like behaviorLimited beddingMale miceMouse modelUnpredictable early life stressAmygdala-prefrontal cortex connectivityChildhood maltreatmentOpen field testFrontolimbic brain regionsResting-state fMRIFrontolimbic connectivityPostnatal stressCortex connectivityAbnormal connectivityAmygdala connectivityAdult miceAnimal modelsFrontolimbic circuitsBrain regionsStress paradigmPrefrontal cortexRobust increaseMice
2011
Affiliative Behavior Requires Juvenile, But Not Adult Neurogenesis
Wei L, Meaney MJ, Duman RS, Kaffman A. Affiliative Behavior Requires Juvenile, But Not Adult Neurogenesis. Journal Of Neuroscience 2011, 31: 14335-14345. PMID: 21976519, PMCID: PMC3204413, DOI: 10.1523/jneurosci.1333-11.2011.Peer-Reviewed Original ResearchConceptsAdult female miceAdult neurogenesisFemale miceSubventricular zoneAblation of neurogenesisLevels of neurogenesisTransgenic mouse approachSubgranular zoneOlfactory deficitsNew neuronsGlobal eliminationBrain circuitsNeurogenesisProfound impairmentMiceJuvenile periodNovel roleAdult femalesSocial explorationMouse approachSocial abnormalitiesMolecular mechanismsAblationFemalesPeriod