2021
ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer
Sarshekeh A, Alshenaifi J, Roszik J, Manyam G, Advani S, Katkhuda R, Verma A, Lam M, Willis J, Shen J, Morris J, Davis J, Loree J, Lee H, Ajani J, Maru D, Overman M, Kopetz S. ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer. Clinical Cancer Research 2021, 27: 1663-1670. PMID: 33414133, PMCID: PMC7956157, DOI: 10.1158/1078-0432.ccr-20-2404.Peer-Reviewed Original ResearchConceptsMicrosatellite stable colorectal cancerColorectal cancerStable colorectal cancerMutant casesCancer Center databaseT-cell markersTumor mutational burdenAT-rich interactive domain 1AUnique molecular subgroupSignificant higher expressionCancer Genome AtlasImmunologic featuresIFNγ expressionImmune activationImmune subtypesTreatment strategiesPreclinical modelsT cellsImmune responseMutational burdenSeparate cohortPatientsTherapy trialsActive subgroupMolecular subgroups
2019
Association of TGF-β expression with intratumoral infiltration of cytotoxic T lymphocytes in patients with microsatellite-stable colorectal cancer.
Mehrvarz Sarshekeh A, Katkhuda R, Verma A, Advani S, Overman M, Maru D, Kopetz S. Association of TGF-β expression with intratumoral infiltration of cytotoxic T lymphocytes in patients with microsatellite-stable colorectal cancer. Journal Of Clinical Oncology 2019, 37: 3577-3577. DOI: 10.1200/jco.2019.37.15_suppl.3577.Peer-Reviewed Original ResearchConsensus molecular subtype 4Colorectal cancerMSS colorectal cancerEMT gene signatureCTL infiltrationIntratumoral infiltrationImmune cellsTumor microenvironmentGene signatureMicrosatellite stable colorectal cancerAssociation of TGFInfiltration of CTLsHigh relapse rateRank correlation analysisCytotoxic T lymphocytesTGF-β expressionTGF-β activationExpression levelsTGF-β pathwayParaffin-embedded samplesRelapse rateImmunotherapy responseMacrophage infiltrationPoor prognosisTumor infiltration