1995
A kinase–cyclin pair in the RNA polymerase II holoenzyme
Liao S, Zhang J, Jeffery D, Koleske A, Thompson C, Chao D, Viljoen M, van Vuuren H, Young R. A kinase–cyclin pair in the RNA polymerase II holoenzyme. Nature 1995, 374: 193-196. PMID: 7877695, DOI: 10.1038/374193a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCyclin-Dependent Kinase 8Cyclin-Dependent KinasesCyclinsFungal ProteinsMolecular Sequence DataMutationProtein Serine-Threonine KinasesRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidTranscription FactorsTranscription, GeneticConceptsRNA polymerase II holoenzymeSRB proteinsKinase functionRNA polymerase II carboxy-terminal domainCyclin-like proteinGeneral transcription factorsRNA polymerase IISuppressors of mutationsNormal transcriptional responseCarboxy-terminal domainPolymerase IITranscriptional regulatorsTranscriptional responseGalactose inductionTranscription factorsRegulatory proteinsTranscription systemHoloenzymeRegulatory roleKinaseProteinBiochemical evidenceGenesVivoSrb11
1994
An RNA polymerase II holoenzyme responsive to activators
Koleske A, Young R. An RNA polymerase II holoenzyme responsive to activators. Nature 1994, 368: 466-469. PMID: 8133894, DOI: 10.1038/368466a0.Peer-Reviewed Original ResearchConceptsRNA polymerase IIGeneral transcription factorsRNA polymerase II holoenzymePolymerase IITranscription factorsPromoter DNAMulti-component complexesGAL4-VP16Initiation factorsRegulatory proteinsHoloenzymeProteinDNAOrdered fashionCerevisiaeTranscriptionVivoPromoterActivatorAssemblyEquimolar amountsComplexes