2019
Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits
Katrancha SM, Shaw JE, Zhao AY, Myers SA, Cocco AR, Jeng AT, Zhu M, Pittenger C, Greer CA, Carr SA, Xiao X, Koleske AJ. Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits. Cell Reports 2019, 26: 2805-2817.e9. PMID: 30840899, PMCID: PMC6436967, DOI: 10.1016/j.celrep.2019.02.022.Peer-Reviewed Original ResearchConceptsHeterozygous coding mutationsDendritic spine densityHippocampus of miceNeurodevelopmental disordersLong-term potentiationDendritic spine defectsPostsynaptic deficitsSpine densityCortical synapsesDendritic arborizationExcitatory neuronsMotor coordinationHaploinsufficient miceKnockout miceTherapeutic interventionsBipolar disorderProtein kinase A (PKA) signalingNeuronal structuresSpine defectsIncreases anxietyMiceDisordersDeficitsCoding mutationsA Signaling
2016
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development
Shapiro LP, Parsons RG, Koleske AJ, Gourley SL. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal Of Neuroscience Research 2016, 95: 1123-1143. PMID: 27735056, PMCID: PMC5352542, DOI: 10.1002/jnr.23960.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnalysis of VarianceAnimalsBrain-Derived Neurotrophic FactorCytoskeletonDendritic SpinesFemaleGene Expression Regulation, DevelopmentalHumansIntegrin beta1MaleMembrane GlycoproteinsMiceMice, TransgenicNeural PathwaysNeuronsPrefrontal CortexReceptor, trkBSignal TransductionSynapsesSynaptophysinConceptsPrefrontal cortexDendritic spinesTropomyosin-related kinase receptor BDifferent adolescent agesKinase receptor BPrevalence of depressionMental health disordersDeep-layer excitatory neuronsRho kinase 2TrkB levelsVentral hippocampusOrbital prefrontal cortexAge-related differencesPsychiatric illnessReceptor BExcitatory neuronsPostnatal brainHealth disordersAnatomical connectionsNeuronal structuresWestern blottingAdolescent ageEarly adulthoodDramatic structural reorganizationPFC subregions
2014
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors
DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL. Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Frontiers In Pharmacology 2014, 5: 228. PMID: 25452728, PMCID: PMC4233985, DOI: 10.3389/fphar.2014.00228.Peer-Reviewed Original ResearchDendritic arborsCocaine exposureDendritic spinesPre-existing structural abnormalitiesAdolescent cocaine exposurePostnatal day 31Prior cocaine exposureCocaine-induced modificationsDrugs of abuseDosing protocolDrug-naïveDrug exposureLocomotor activationExcitatory neuronsLong-term effectsAnimal modelsDay 31Structural abnormalitiesOrbitofrontal cortexBehavioral effectsBrain structuresMiceNeurobehavioral phenotypesCocaine vulnerabilityCell populationsAblation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex
Cooper MA, Koleske AJ. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. The Journal Of Comparative Neurology 2014, 522: 3351-3362. PMID: 24752666, PMCID: PMC4107058, DOI: 10.1002/cne.23615.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell FractionationCells, CulturedDendritic SpinesDisks Large Homolog 4 ProteinGene Expression RegulationGreen Fluorescent ProteinsGuanylate KinasesMembrane ProteinsMiceMice, TransgenicMitogen-Activated Protein Kinase 3NestinNeuronsPrefrontal CortexReceptor, ErbB-4SynapsesTransfectionConceptsDendritic spine densitySpine densityExcitatory pyramidal cellsExcitatory neuronsPrefrontal cortexPyramidal cellsDendritic spinesErbB4 functionAblation of ErbB4Dendritic spine lossCortical neuronal culturesMouse prefrontal cortexDendritic spine developmentMonths of ageSynaptic plasma membrane preparationsSpine lossWeanling miceDorsomedial prefrontal cortexPsychiatric disordersKnockout miceMature spinesErbB4 signalingSynaptic plasticityNeuronal culturesDisease pathology