2019
Non-acylated Wnts Can Promote Signaling
Speer KF, Sommer A, Tajer B, Mullins MC, Klein PS, Lemmon MA. Non-acylated Wnts Can Promote Signaling. Cell Reports 2019, 26: 875-883.e5. PMID: 30673610, PMCID: PMC6429962, DOI: 10.1016/j.celrep.2018.12.104.Peer-Reviewed Original Research
2018
Anoctamin-6 regulates ADAM sheddase function
Veit M, Koyro K, Ahrens B, Bleibaum F, Munz M, Rövekamp H, Andrä J, Schreiber R, Kunzelmann K, Sommer A, Bhakdi S, Reiss K. Anoctamin-6 regulates ADAM sheddase function. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research 2018, 1865: 1598-1610. PMID: 30327201, DOI: 10.1016/j.bbamcr.2018.08.011.Peer-Reviewed Original ResearchConceptsAnoctamin 6Scramblase activityHuman umbilical vein endothelial cellsTNF receptor 1Vital cellular functionsPhospholipid scramblase activityPS exposureHEK293T cellsTGF-alphaTransformation of cellsSheddase functionTransmembrane substratesCellular functionsADAM17 substratesPlasma membraneUmbilical vein endothelial cellsInhibitor experimentsSheddase activitySubstrate cleavageImportant regulatorVein endothelial cellsActivator PMAProminent memberAmphiregulinEndothelial cells
2012
Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation*
Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrä J, Bhakdi S, Reiss K. Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation*. Journal Of Biological Chemistry 2012, 287: 23678-23689. PMID: 22613720, PMCID: PMC3390642, DOI: 10.1074/jbc.m112.362756.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAM10 ProteinADAM17 ProteinAdenosine TriphosphateAmyloid Precursor Protein SecretasesAnimalsBlotting, WesternCadherinsCell LineCell SurvivalCells, CulturedDose-Response Relationship, DrugEmbryo, MammalianErbB ReceptorsExtracellular Signal-Regulated MAP KinasesFibroblastsHEK293 CellsHumansKeratinocytesMelittenMembrane ProteinsMiceMice, KnockoutModels, BiologicalPhosphorylationReceptors, Purinergic P2X7Reverse Transcriptase Polymerase Chain ReactionConceptsAnti-cancer agentsP2 receptorsADAM activationP2 receptor antagonistsRelease of TGFMultiple cellular functionsPurinergic P2 receptorsAdhesion molecule E-cadherinE-cadherinReceptor antagonistP2X7 receptorHuman HaCaT keratinocytesCellular functionsPresence of ATPasesDownstream eventsATP releaseEGFR phosphorylationHuman neutrophilsEGF receptorEndothelial cellsERK1/2 phosphorylationKeratinocyte proliferationReceptorsBee venomCell migration