2018
Smoothening out the patches
Sommer A, Lemmon MA. Smoothening out the patches. Science 2018, 362: 26-27. PMID: 30287647, PMCID: PMC6421564, DOI: 10.1126/science.aav1025.Peer-Reviewed Original ResearchConceptsProtein PatchedTransmembrane protein PatchedCryo-electron microscopyRecent crystal structureUnique molecular mechanismImportant tumor suppressorKey HedgehogImportant new insightsMolecular mechanismsTumor suppressorMolecular eventsHedgehogCell membranePathwayCholesterol transportNew insightsNew roleHomologous ligandsMetazoansPatchedSmoothenedSuppressorRecent reportsProteinCrystal structure
2015
Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity
Düsterhöft S, Michalek M, Kordowski F, Oldefest M, Sommer A, Röseler J, Reiss K, Grötzinger J, Lorenzen I. Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity. Biochemistry 2015, 54: 5791-5801. PMID: 26348730, DOI: 10.1021/acs.biochem.5b00497.Peer-Reviewed Original ResearchConceptsMembrane-proximal domainJuxtamembrane segmentSubstrate recognitionMembrane-anchored proteinsAmino acid residuesActivity of ADAM17Extracellular regionBiological processesMajor sheddasesAcid residuesCancer progressionLipid bilayersMetalloprotease 17Key mediatorInterleukin-6 receptorDisintegrinADAM17SheddasesDomainProteinInteractsResiduesDifferentiationActivityWide variety