2021
Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development
Li J, Geraldo LH, Dubrac A, Zarkada G, Eichmann A. Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development. Journal Of The American Society Of Nephrology 2021, 32: 2255-2272. PMID: 34341180, PMCID: PMC8729857, DOI: 10.1681/asn.2020111640.Peer-Reviewed Original ResearchConceptsGlomerular vascularizationRobo receptorsKidney functionVascular developmentGlomerular perfusionKidney diseaseGlomerular endotheliumLigand trapInhibited vascularizationSlit2-RoboEndothelial proliferationGlomerular capillariesEndothelial compartmentGlomerular angiogenesisPerfusion analysisKidney vasculatureVascularizationUreteric bud branchingNovel roleAxon guidanceNephron developmentBlood filtrationReceptorsAngiogenesisGene deletion
2014
Emergence of Endothelial Cells During Vascular Development
Eichmann A, Pardanaud L. Emergence of Endothelial Cells During Vascular Development. 2014, 3-23. DOI: 10.1007/978-2-8178-0466-8_1.Peer-Reviewed Original Research
2010
Regulation of blood vessel patterning and guidance
Eichmann A. Regulation of blood vessel patterning and guidance. The FASEB Journal 2010, 24: 62.3-62.3. DOI: 10.1096/fasebj.24.1_supplement.62.3.Peer-Reviewed Original ResearchVertebrate embryonic developmentBlood vessel patterningLigand-receptor interactionsKey ligand-receptor interactionsVertebrate embryosVessel patterningZebrafish embryosPrimitive tubeGrowth factor gradientsEmbryonic developmentMesodermal cellsMajor axial vesselsMolecular mechanismsStereotyped architectureVascular developmentVascular systemSimilar branching patternsFactor gradientsCardinal veinEmbryosPrimitive vesselsBranched networkPattern formationEndothelial cellsHemodynamic forces
2009
Separating genetic and hemodynamic defects in neuropilin 1
Jones E, Yuan L, Breant C, Watts R, Eichmann A. Separating genetic and hemodynamic defects in neuropilin 1. The FASEB Journal 2009, 23: 311.1-311.1. DOI: 10.1096/fasebj.23.1_supplement.311.1.Peer-Reviewed Original ResearchVascular developmentProper vascular developmentYolk sac blood vesselsGenetic defectsMutant embryosBiochemical signalingYolk sac arteriesCardiovascular developmentMouse embryo cultureEmbryo growthBlood flowPhysiological functionsHemodynamic defectsVascular defectsVascular formationEmbryo cultureBiological senseNeuropilin-1Proper blood flowPhysical forces
2008
Separating Genetic and Hemodynamics Effects In Nrp1 Knockout Embryos
Jones E, Yuan L, Breant C, Watts R, Eichmann A. Separating Genetic and Hemodynamics Effects In Nrp1 Knockout Embryos. The FASEB Journal 2008, 22: 1143.2-1143.2. DOI: 10.1096/fasebj.22.1_supplement.1143.2.Peer-Reviewed Original ResearchVasculogenesis and Angiogenesis in Development
Eichmann A, Bouvrée K, Pardanaud L. Vasculogenesis and Angiogenesis in Development. 2008, 31-45. DOI: 10.1007/978-3-540-33177-3_2.Peer-Reviewed Original Research
2007
Activation of the UNC5B receptor by Netrin‐1 inhibits neovascularization
Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, Bouvrée K, Breant C, Bono F, Autiero M, Claes F, Carmeliet P, Tessier‐Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin‐1 inhibits neovascularization. The FASEB Journal 2007, 21: a746-a746. DOI: 10.1096/fasebj.21.6.a746-b.Peer-Reviewed Original ResearchNetrin receptor UNC5BEmbryonic vascular patterningFull-length receptorPostnatal vascular developmentPostnatal mouse retinaVascular patterningPotential anti-angiogenic targetCell repulsionAnti-angiogenic targetVascular developmentNetrin-1 stimulationPathological angiogenesisAortic ringsReceptor UNC5BUNC5B receptorUNC5BMouse retinaReceptor activationAxonal growthNetrin-1Tumor angiogenesisTumor modelInhibits neovascularizationAngiogenesisNeovascularization
2001
Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo.
Moyon D, Pardanaud L, Yuan L, Bréant C, Eichmann A. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development 2001, 128: 3359-70. PMID: 11546752, DOI: 10.1242/dev.128.17.3359.Peer-Reviewed Original ResearchConceptsArterial-venous differentiationEndothelial plasticityEndothelial cellsEmbryonic day 7Jugular veinDay 7Vessel wallPrimary vascular systemNeuropilin-1Quail-chick chimerasHost arteryVenous fateEmbryonic developmentTransmembrane receptorsVenous markersEmbryonic day 2Venous endothelial cellsAortic endothelial cellsAvian embryosVascular developmentMost arteriesCarotid arteryVessel identityDay 11 embryosDorsal aorta